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National Institute of Environmental Health Sciences

 

Person Details

Superfund Research Program

Michael S. Denison

University of California-Davis
Department of Environmental Toxicology
4245 Meyer Hall
One Shields Avenue
Davis, CA 95616
Phone: 530-752-3879
Fax: 530-752-3394
Email:

Projects

Research Briefs

Patents

  • Bioassay for detecting 2,3,7,8-tetrachlorodibenzo-para-dioxin and TCDD-like compounds and novel recombinant cell line useful therefore

Superfund Sites

Frontier Fertilizer

  • University of California-Davis: Development and Applications of Integrated In Vitro and Cell-Based Bioassays

Publications

2014
  • Addeck, Amr, Kim Croes, Kersten Van Langenhove, Michael S. Denison, Ahmed S. Afify, Yue Gao, Marc Elskens, and Willy Baeyens. 2014. Time-integrated monitoring of dioxin-like polychlorinated biphenyls (dl-PCBs) in aquatic environments using the ceramic toximeter and the CALUX bioassay. Talanta.   120:413-418. doi:10.1016/j.talanta.2013.12.017  
  • Addeck, Amr, Kim Croes, Kersten Van Langenhove, Michael S. Denison, Ahmed Elhamalawy, Marc Elskens, and Willy Baeyens. 2014. Time-integrated monitoring of polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofurans (PCDD/Fs) in urban and industrial wastewaters using a ceramic toximeter and the CALUX bioassay. Chemosphere.   94:27-35. doi:10.1016/j.chemosphere.2013.08.075  
  • DeGroot, Danica E. and Michael S. Denison. 2014. Nucleotide specificity of DNA binding of the aryl hydrocarbon receptor: ARNT complex is unaffected by Ligand structure. Toxicological Sciences.   137(1):102-113. doi:10.1093/toxsci/kft234  
  • DeGroot, Danica E., Ai Hayashi, and Michael S. Denison. 2014. Lack of ligand-selective binding of the aryl hydrocarbon receptor to putative DNA binding sites regulating expression of Bax and paraoxonase 1 genes. Archives of Biochemistry and Biophysics.   541:13-20. doi:10.1016/j.abb.2013.10.021  
2013
  • Brennan, Jennifer C., Michael S. Denison, Dirk M. Holstege, Prokopios Magiatis, Jerry L. Dallas, Elisa G. Gutierrez, Anatoly A. Soshilov, and James R. Millam. 2013. 2,3-cis-2R, 3R-(-)-epiafzelechin-3-O-p-coumarate, a novel flavan-3-ol isolated from Fallopia convolvulus seed, is an estrogen receptor agonist in human cell lines. BMC Complementary and Alternative Medicine. 13:133. doi:10.1186/1472-6882-13-133  
  • Croes, Kim, A. Colles, G. Koppen, S. de Galan, T. Vandermarken, E. Govarts, L. Bruckers, V. Nelen, G. Schoeters, N. Van Larebeke, M. Mampaey, W. Baeyens, and Michael S. Denison. 2013. Determination of PCDD/Fs, PBDD/Fs and dioxin-like PCBs in human milk from mothers residing in the rural areas in Flanders, using the CALUX bioassay and GC-HRMS. Talanta.   113:99-105. doi:10.1016/j.talanta.2013.03.086  
  • Fraccalvieri, Domenico, Anatoly A. Soshilov, Sibel I. Karchner, Diana G. Franks, Alessandro Pandini, Laura Bonati, Mark E. Hahn, and Michael S. Denison. 2013. Comparative analysis of homology models of the AH receptor ligand binding domain: Verification of structure-function predictions by site-directed mutagenesis of a nonfunctional receptor. Biochemistry.   52:714-725. doi:10.1021/bi301457f  
  • He, Guochun, Jing Zhao, Jennifer C. Brennan, Alessandra A. Affatato, Bin Zhao, Robert H. Rice, and Michael S. Denison. 2013. Cell-based assays for identification of aryl hydrocarbon (Ah) receptor activators. In: Optimization of Drug Discovery: In Vitro Methods (2E). Humana Press, New York, NY. pp.221-235.
  • Hu, Qin, Guochun He, Jing Zhao, Anatoly A. Soshilov, Michael S. Denison, Aiqian Zhang, Huijun Yin, Domenico Fraccalvieri, Laura Bonati, Qunhui Xie, and Bin Zhao. 2013. Ginsenosides are novel naturally-occurring aryl hydrocarbon receptor ligands. PLoS ONE.   8:e66258. doi:10.1371/journal.pone.0066258  
  • Kamenickova, Alzbeta, Eva Anzenbacherova, Petr Pavek, Anatoly A. Soshilov, Michael S. Denison, Pavel Anzenbacher, and Zdenek Dvorak. 2013. Pelargonidin activates the AhR and induces CYP1A1 in primary human hepatocytes and human cancer cell lines HepG2 and LS174T. Toxicology Letters.   218(3):253-259. doi:10.1016/j.toxlet.2013.01.020  
  • Kamenickova, Alzbeta, Eva Anzenbacherova, Petr Pavek, Anatoly A. Soshilov, Michael S. Denison, Michaela Zapletalova, Pavel Anzenbacher, and Zdenek Dvorak. 2013. Effects of anthocyanins on the AhR-CYP1A1 signaling pathway in human hepatocytes and human cancer cell lines. Toxicology Letters.   221(1):1-8. doi:10.1016/j.toxlet.2013.05.007  
  • Zhao, Bin, Jessica E. Bohonowych, Alicia R. Timme-Laragy, Dawoon Jung, Alessandra A. Affatato, Robert H. Rice, Richard T. Di Giulio, and Michael S. Denison. 2013. Common commercial and consumer products contain activators of the aryl hydrocarbon (dioxin) receptor. PLoS ONE.   8(2):e56860. doi:10.1371/journal.pone.0056860  
2012
  • Addeck, Amr, Kim Croes, Kersten Van Langenhove, Michael S. Denison, Marc Elskens, and W. Baeyens. 2012. Dioxin analysis in water by using a passive sampler and CALUX bioassay. Talanta.   88:73-78. doi:10.1016/j.talanta.2011.10.009  
  • Brander, Susanne M., Guochun He, Kelly L. Smalling, Michael S. Denison, and Gary N. Cherr. 2012. The in vivo estrogenic and in vitro anti-estrogenic activity of permethrin and bifenthrin. Environmental Toxicology and Chemistry.   31(12):2848-2855. doi:10.1002/etc.2019  
2011
  • Baston, David S. and Michael S. Denison. 2011. Considerations for potency equivalent calculations in the Ah receptor-based CALUX bioassay: normalization of superinduction results for improved sample potency estimation. Talanta.   83(5):1415-1421. doi:10.1016/j.talanta.2010.11.035  
  • Croes, Kim, Kersten Van Langenhove, E. Den Hond, L. Bruckers, A. Colles, G. Koppen, I. Loots, V. Nelen, G. Schoeters, T. Nawrot, N. Van Larebeke, Michael S. Denison, T. Vandermarken, Marc Elskens, and W. Baeyens. 2011. Quantification of PCDD/Fs and dioxin-like PCBs in small amounts of human serum using the sensitive H1L7.5c1 mouse hepatoma cell line: Optimization and analysis of human serum samples from adolescents of the Flemish human biomonitoring program FLEHS II. Talanta.   85:2484-2491. doi:10.1016/j.talanta.2011.07.103  
  • Denison, Michael S., Anatoly A. Soshilov, Guochun He, Danica E. DeGroot, and Bin Zhao. 2011. Exactly the Same but Different: Promiscuity and Diversity in the Molecular Mechanisms of Action of the Aryl Hydrocarbon (Dioxin) Receptor. Toxicological Sciences.   124:1-22. doi:10.1093/toxsci/kfr218  
  • He, G., Bin Zhao, and Michael S. Denison. 2011. Identification of benzothiazole derivatives and polycyclic aromatic hydrocarbons as aryl hydrocarbon receptor agonists present in tire extracts. Environmental Toxicology. 30:1915-1925. doi:10.1002/etc.581  
  • He, Guochun, Tomoaki Tsutsumi, David S. Baston, Bin Zhao, Jing Zhao, Sharon Heath-Pagliuso, and Michael S. Denison. 2011. Third-Generation Ah Receptor-Responsive Luciferase Reporter Plasmids: Amplification of Dioxin-Responsive Elements Dramatically Increases CALUX Bioassay Sensitivity and Responsiveness. Toxicological Sciences.   123:511-522. doi:10.1093/toxsci/kfr189  
  • Motto, I., A. Bordogna, Anatoly A. Soshilov, Michael S. Denison, and L. Bonati. 2011. New Aryl Hydrocarbon Receptor Homology Model Targeted To Improve Docking Reliability. Journal of Chemical Information and Modeling.   51:2868-2881. doi:10.1021/ci2001617  
  • Motto, I., Anatoly A. Soshilov, Michael S. Denison, and L. Bonati. 2011. A new aryl hydrocarbon receptor homology model targeted to improve docking reliability. Journal of Chemical Information and Modeling.   51:2868-2881. doi:10.1021/ci2001617  
2010
  • Boitano, A., J. Wang, R. Romeo, L. Bouchez, A. Parker, S.E. Sutton, J. Walker, C. Flaveny, G.H. Perdew, Michael S. Denison, P. Schultz, and M. Cooke. 2010. Aryl Hydrocarbon Receptor Antagonists Promote the Expansion of Human Hematopoietic Stem Cells. Science.   329(5997):1345-1348. doi:10.1126/science.1191536  
  • Kennedy, Karen, Miroslava Macova, Michael E. Bartkow, Darryl W. Hawker, Bin Zhao, Michael S. Denison, and Jochen F. Mueller. 2010. Effect based monitoring of seasonal ambient air exposures in Australia sampled by PUF passive air samplers. Atmospheric Pollution Research.   1(1):50-58. doi:10.5094/APR.2010.008  
  • Zhao, Bin, David S. Baston, Elaine M. Khan, Claudio Sorrentino, and Michael S. Denison. 2010. Enhancing the response of CALUX and CAFLUX cell bioassays for quantitative detection of dioxin-like compounds. Science China-Chemistry.   53(5):1010-1016. doi:10.1007/s11426-010-0142-8  
  • Zhao, Bin, D. DeGroot, Ai Hayashi, G. He, and Michael S. Denison. 2010. CH223191 Is a Ligand-Selective Antagonist of the Ah (Dioxin) Receptor. Toxicological Sciences.   117(2):393-403. doi:10.1093/toxsci/kfq217  
2009
  • Jaikanlaya, Chate, Daam Settachan, Michael S. Denison, K Mathuros Ruchirawat, and Martin van den Berg. 2009. PCBs contamination in seafood species at the Eastern Coast of Thailand. Chemosphere.   76(2):239-249. doi:10.1016/j.chemosphere.2009.03.018  
  • Kanematsu, Masakazu, Ai Hayashi, Michael S. Denison, and Thomas M. Young. 2009. Characterization and potential environmental risks of leachate from shredded rubber mulches. Chemosphere.   76(7):952-958. doi:10.1016/j.chemosphere.2009.04.026  
  • Kennedy, Karen, Miroslava Macova, Michael E. Bartkow, Darryl W. Hawker, Bin Zhao, Michael S. Denison, Jochen F. Mueller, and Frederic Leusch. 2009. Assessing indoor air exposures using passive sampling with bioanalytical methods for estrogenicity and aryl hydrocarbon receptor activity. Analytical and Bioanalytical Chemistry.   394(5):1413-1421. doi:10.1007/s00216-009-2825-6  
  • Morisseau, Christophe, Oleg Merzlikin, Amy Lin, G. He, Wei Feng, Isela Padilla, Michael S. Denison, Isaac N. Pessah, and Bruce D. Hammock. 2009. Toxicology in the fast lane: application of high-throughput bioassays to detect modulation of key enzymes and receptors. Environmental Health Perspectives. 117(12):1867-1872.
  • Palumbo, Amanda J., Michael S. Denison, Serge I. Doroshov, and Ronald S. Tjeerdema. 2009. Reduction of vitellogenin synthesis by an aryl hydrocarbon receptor agonist in the white sturgeon (Acipenser Transmontamus). Environmental Toxicology and Chemistry.   28(8):1749-1755. doi:10.1897/08-481.1  
2008
  • Chen, Jiangang, Ki Chang Ahn, Bin Zhao, Michael S. Denison, Bill L. Lasley, Isaac N. Pessah, Dietmar Kultz, Daniel PY Chang, Shirley J. Gee, Bruce D. Hammock, and Gennady Cherednichenko. 2008. In Vitro Biologic Activities of the Antimicrobials Triclocarban, Its Analogs, and Triclosan in Bioassay Screens: Receptor-Based Bioassay Screens. Environmental Health Perspectives. 116:1203-1210. doi:10.1289/ehp.11200  
2007
  • Brown, David J., J. Orelien, John D. Gordon, Andrew C. Chu, Michael D. Chu, M. Nakamura, H. Handa, F. Kayama, Michael S. Denison, and G.C. Clark. 2007. Mathematical model developed for environmental samples: prediction of GC/MS dioxin TEQ from XDS-CALUX bioassay data. Environmental Science & Technology.   41(12):4354-60.
  • Nording, Malin, Michael S. Denison, David S. Baston, Ylva Persson, Erik Spinnel, and Peter Haglund. 2007. Analysis of dioxins in contaminated soils with the calux and caflux bioassays, an immunoassay, and gas chromatography/high-resolution mass spectrometry. Environmental Toxicology and Chemistry.   26(6):1122-9.
2006
  • Denison, Michael S., Dal-ho Han, Scott R. Nagy, Bin Zhao, David S. Baston, Ai Hayashi, Marie Knockaert, and Laurent Meijer. 2006. Indirubins as activators of the aryl hydrocarbon receptor signal transduction pathways. Chapter 16 in: Indirubin, The Red Shade of Indigo. Roscoff, pp.157-167.
  • Denison, Michael S., Elaine M. Khan, Claudio Sorrentino, and Bin Zhao. 2006. Enhanced CALUX and CAFLUX cell bioassay responses through intracellular signaling pathways and incubation temperature. Organohalogen Compounds. 68:1265-1268.
  • Gordon, John D., Michael S. Denison, Andrew C. Chu, Michael D. Chu, Cynthia Matherly, F. Kayama, and George C. Clark. 2006. Proposed classification system for tier-1 screening of estrogenic EDC using the Lumi-Cell ER bioassay. Organohalogen Compounds. 68:1273-1276.
  • Klein, Gail P., Erin M. Hodge, Miriam L. Diamond, Amelia Yip, Tom Dann, Gary Stern, Michael S. Denison, and Patricia A. Harper. 2006. Gas-phase ambient air contaminants exhibit significant dioxin-like and estrogen-like activity In vitro. Environmental Health Perspectives. 114(5):697-703.
  • Peters, A.K., Pim EG Leonards, Bin Zhao, Ake Bergman, Michael S. Denison, and Martin van den Berg. 2006. Determination of in vitro relative potency (REP) values for mono-ortho polychlorinated biphenyls after purification with active charcoal. Toxicology Letters.   165(3):230-241.
  • Peters, A.K., S. Nijmeijer, K. Gradin, M. Backlund, Ake Bergman, L. Poellinger, Michael S. Denison, and Martin van den Berg. 2006. Interactions of Polybrominated Diphenyl Ethers with the Aryl Hydrocarbon Receptor Pathway. Toxicological Sciences.   92(1):133-142.
  • Zhao, Bin, David S. Baston, Bruce D. Hammock, and Michael S. Denison. 2006. Interaction of diuron and related substituted phenylureas with the Ah receptor pathway. Journal of Biochemical and Molecular Toxicology.   20(3):103-113.
  • Zhao, Bin, Jessica E. Bohonowych, and Michael S. Denison. 2006. Differential responsiveness of the Ah receptor dependent gene expression induced by HAHs and PAHs. Organohalogen Compounds. 68:1745-1748.
2005
  • Clark, George C., J. Orelien, John D. Gordon, Andrew C. Chu, Michael D. Chu, and Michael S. Denison. 2005. Mathematical model predictions of GC/MS data for dioxin contaminated environmental samples using CALUX┬« by XDS. Organohalogen Compounds. 67:50-53.
  • Gordon, John D., Andrew C. Chu, Michael D. Chu, Cynthia Matherly, Michael S. Denison, Guerry Grune, and George C. Clark. 2005. Estrogenic potency of many popular suncreens and it's "non-active" components detected using the LUMI-cell" ER bioassay. Organohalogen Compounds. 67:
  • Peters, A.K., S. Nijmeijer, Bin Zhao, Michael S. Denison, Ake Bergman, J Thomas Sanderson, and Martin van den Berg. 2005. Polybrominated diphenyl ethers (PBDEs) antagonize or inhibit TCDD induced CYP1A1 activity in various in vitro systems. Organohalogen Compounds. 67:2290-2293.
  • Windal, Isabelle, Michael S. Denison, Linda S. Birnbaum, Nathalie Van Wouwe, Willy Baeyens, and Leo Goeyens. 2005. Chemically activated luciferase gene expression (CALUX) cell bioassay analysis for the estimation of dioxin-like activity: critical parameters of the CALUX procedure that impact assay results. Environmental Science & Technology.   39(19):7357-7364.
2004
  • Bohonowych, Jessica E. and Michael S. Denison. 2004. Binding of 2,3,7,8-tetrachlorodibehzo-p-dioxin to the AhR from various species is essentially irreversible. Organohalogen Compounds. 55:3291-3295.
  • Brown, David J., Ilse Van Overmeire, Leo Goeyens, Michael S. Denison, Michael J. De Vito, and George C. Clark. 2004. Analysis of Ah receptor pathway activation by brominated flame retardants. Organohalogen Compounds. 55(11):1509-1518.
  • Denison, Michael S., W.J. Rogers, Jessica E. Bohonowych, Bin Zhao, Aparajita Dey, Roger S. Williams, David M. Pollock, David W. Stepp, John W. Newman, Bruce D. Hammock, and John D. Imig. 2004. Promiscuous ligand-dependent activation of the Ah receptor: chemicals in crude extracts from commercial and consumer products bind to and activate the Ah receptor and Ah receptor-dependent gene expression. Organohalogen Compounds. 66:2966-2971.
  • Denison, Michael S., Bin Zhao, David S. Baston, George C. Clark, Hiroshi Murata, and Dal-ho Han. 2004. Recombinant cell bioassay systems for the detection and relative quantitation of halogenated dioxins and related chemicals. Talanta.   63(5):1123-1133.
  • Gordon, John D., Andrew C. Chu, Michael D. Chu, Michael S. Denison, and George C. Clark. 2004. Detection of estrogen receptor endocrine disrupter potency of commonly used organochlorine pesticides using the LUMI-CELL ER" bioassay. Organohalogen Compounds. 66:169-174.
  • Han, Dal-ho, Scott R. Nagy, and Michael S. Denison. 2004. Comparison of recombinant cell bioassays for the detection of Ah receptor agonists. Biofactors. 20(1):11-22.
  • Knockaert, Marie, Marc Blondel, Stephane Bach, Maryse Leost, Cem Elbi, Gordan L. Hager, Scott R. Nagy, Dal-ho Han, Michael S. Denison, Martine Ffrench, Xiaozhou P. Ryan, Prokopios Magiatis, Panos Polychronopoulos, Paul Greengard, Leandros Skaltsounis, and Laurent Meijer. 2004. Independent actions on cyclin-dependent kinases and aryl hydrocarbon receptor mediate the antiproliferative effects of indirubins. Oncogene.   23(25):4400-4412.
  • Zhao, Bin and Michael S. Denison. 2004. Development and characterization of a green fluorescent protein-based rat cell bioassay system for detection of Ah receptor ligands. Organohalogen Compounds. 66:3285-3290.
  • Zhao, Bin, Scott R. Nagy, Jane M. Rogers, Mike H. Nantz, Mark Kurth, Mark Springsteel, and Michael S. Denison. 2004. Identification and analysis of novel flavonoid agonists and antagonists for the Ah and estrogen receptor. Organohalogen Compounds. 66:2919-2924.
2003
  • Baston, David S., Scott R. Nagy, Mike H. Nantz, Mark Kurth, Mark Springsteel, and Michael S. Denison. 2003. Identification of novel agonists and antagonists of the Ah receptor signal transduction pathway. Organohalogen Compounds. 65:142-145.
  • Denison, Michael S., Dal-ho Han, Sharon Heath-Pagliuso, John Scovill, Laurent Meijer, Leandros Skaltounis, Elizabeth MJ Gillam, and Scott R. Nagy. 2003. Activation of the Ah receptor and Ah receptor signal transduction pathway by tryptophan-derived agonists. Organohalogen Compounds. 65:90-93.
  • Denison, Michael S. and Scott R. Nagy. 2003. Activation of the aryl hydrocarbon receptor by structurally diverse exogenous and endogenous chemicals. Annual Review of Pharmacology and Toxicology.   43:309-334.
  • Gordon, John D., Andrew C. Chu, Michael D. Chu, C.L. Taylor, Michael S. Denison, and G.C. Clark. 2003. Validation of the LUMI-CELLTM ER recombinant bioassay for rapid evaluatin of chemicals for potential estrogenic activity. Organohalogen Compounds. 65:78-81.
  • Han, Dal-ho, Bin Zhao, David S. Baston, Mark Springsteel, Mark Kurth, Mike H. Nantz, and Michael S. Denison. 2003. Identification and characterization of novel flavone agonists of th Ah receptor. Organohalogen Compounds. 65:126-129.
  • Jeuken, Anoek, Bart JG Keser, Elaine M. Khan, Abraham Brouwer, Jan H. Koeman, and Michael S. Denison. 2003. Activation of the Ah receptor by extracts of dietary herbal supplements, vegetables, and fruits. Journal of Agricultural and Food Chemistry.   51(18):5478-5487.
  • Monk, Scott A., Michael S. Denison, and Robert H. Rice. 2003. Reversible stepwise negative regulation of CYP1A1 in cultured rat epidermal cells. Archives of Biochemistry and Biophysics.   419(12):158-169.
  • Wuilloud, Jorgelina C A, Rodolfo G. Wuilloud, Baki M. Sadi, Joseph A. Caruso, Michael S. Denison, and Scott R. Nagy. 2003. Trace humic and fulvic acid determination in natural water by cloud point extraction/preconcentration using non-ionic and cationic surfactants with FI-UV detection. Analyst.   128(5):453-458.
  • Zhao, Bin, Scott R. Nagy, David S. Baston, D. Han, Mike H. Nantz, Mark Kurth, Mark Springsteel, and Michael S. Denison. 2003. Screening and analysis of novel naphthoflavone ligands for the Ah receptor. Organohalogen Compounds. 65:102-105.
2002
  • Denison, Michael S., Scott R. Nagy, Michael H. Ziccardi, George C. Clark, Michael D. Chu, David J. Brown, Guomin Shan, Yukio Sugawara, Shirley J. Gee, James R. Sanborn, and Bruce D. Hammock. 2002. Bioanalytical approaches for the detection of dioxin and related halogenated aromatic hydrocarbons. In: Biomarkers of Environmentally Associated Disease: Technologies, Concepts, and Perspectives   . CRC Press Company, Boca Raton, FL. pp.483-494.
  • Han, Dal-ho, Scott R. Nagy, and Michael S. Denison. 2002. Recombinant cell lines for the detection of dioxins and Ah receptor ligands - not all assays are created equal. Organohalogen Compounds. 58:421-424.
  • Khan, Elaine M. and Michael S. Denison. 2002. NF-kB is involved in cross-talk between Ah receptor and signal transduction pathways. Organohalogen Compounds. 59:411-414.
  • Lashley, Matthew R., Edmund J. Niedzinski, Jane M. Rogers, Michael S. Denison, and Mike H. Nantz. 2002. Synthesis and estrogen receptor affinity of a 4-hydroxytamoxifen-labeled ligand for diagnostic imaging. Bioorganic & Medicinal Chemistry.   10(12):4075-4082.
  • Nagy, Scott R. and Michael S. Denison. 2002. Specificity of nuclear protein binding to a CYP1A1 negative regulatory element. Biochemical and Biophysical Research Communications.   296(4):799-805.
  • Nagy, Scott R., Gang-yu Liu, Kit S. Lam, and Michael S. Denison. 2002. Identification of novel Ah receptor agonists using a high-throughput green fluorescent protein-based recombinant cell bioassay. Biochemistry.   41(3):861-868.
  • Nagy, Scott R., James R. Sanborn, Bruce D. Hammock, and Michael S. Denison. 2002. Development of a green fluorescent protein based cell bioassay for the rapid and inexpensive detection and characterization of AhR agonists. Toxicological Sciences.   65(2):200-210.
  • Natarajan, Kala, James W. Overstreet, Jane M. Rogers, Michael S. Denison, Jiangang Chen, Pete N. Lohstroh, Daniel S. McConnell, and Bill L. Lasley. 2002. Detection of xenoestrogens in serum after immunoprecipitation of endogenous steroidal estrogens. Environmental Health Perspectives. 110(8):791-795.
  • Rogers, Jane M. and Michael S. Denison. 2002. Analysis of the antiestrogenic activity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in human ovarian carcinoma BG-1 cells. Molecular Pharmacology.   61(6):1393-1403.
  • Rushing, S.Renee and Michael S. Denison. 2002. The silencing mediator of retinoic acid and thyroid hormone receptors can interact with the aryl hydrocarbon (Ah) receptor but fails to repress Ah receptor-dependent gene expression. Archives of Biochemistry and Biophysics.   403(2):189-201.
  • Ziccardi, Michael H., Ian A. Gardner, and Michael S. Denison. 2002. Application of the luciferase recombinant cell culture bioassay system for the analysis of polycyclic aromatic hydrocarbons. Environmental Toxicology and Chemistry.   21(10):2027-2033.
  • Ziccardi, Michael H., Ian A. Gardner, Jonna AK Mazet, and Michael S. Denison. 2002. Application of the luciferase cell culture bioassay for the detection of refined petroleum products. Marine Pollution Bulletin.   44(10):983-991.
2001
  • Monk, Scott A., Michael S. Denison, and Robert H. Rice. 2001. Transient expression of CYP1A1 in rat epithelial cells cultured in suspension. Archives of Biochemistry and Biophysics.   393(1):154-162.
  • Rogers, Jane M. and Michael S. Denison. 2001. Analysis of the anti-estrogen effect of TCDD in human ovarian carcinoma (BG-1) cells. Organohalogen Compounds. 53:5-9.
  • Seidel, Shawn D., Greg M. Winters, Jane M. Rogers, Michael H. Ziccardi, Violet Li, Bart JG Keser, and Michael S. Denison. 2001. Activation of the Ah receptor signaling pathway by prostaglandins. Journal of Biochemical and Molecular Toxicology.   15(4):187-196.
  • Ziccardi, Michael H., Ian A. Gardner, and Michael S. Denison. 2001. Application of the luciferase recombinant cell culture bioassay for detection of dioxin-like activity of PAHs in the serum of wildlife. Organohalogen Compounds. 54:73-76.
2000
  • Arrieta, Daniel E., Cynthia Ontiveros, Michael S. Denison, and Barbara Shayne Washburn. 2000. Ah receptor mediated effects of particulate organic extracts from the Paso Del Norte airshed along the U.S.-Mexico border. Organohalogen Compounds. 45:212-215.
  • Bohonowych, Jessica E., Jane M. Rogers, Anoek Jeuken, and Michael S. Denison. 2000. Activation of Ah and estrogen receptor based cell bioassay systems by extracts of natural dietary herbal supplements. Organohalogen Compounds. 45:240-243.
  • Heath-Pagliuso, Sharon, Rebecca Mui, Anna Milici, Scott Giese, Regina Chin, and Michael S. Denison. 2000. Tryptophan metabolites, indole-3-pyruvic acid, DL-3-indolelactic acid, L-kynurenine, and kynurenic acid activate Ah receptor signal transduction. Organohalogen Compounds. 49:289-292.
  • Nagy, Scott R., Gang Lui, Kit S. Lam, and Michael S. Denison. 2000. A green fluorescent protein based recombinant cell bioassay for the detection of activators of the aryl hydrocarbon receptor: application for screening of a 1,5-dialkylamino-2,4-dinitrobenzene combinatorial chemical library. Organohalogen Compounds. 45:232-235.
  • Rogers, Jane M. and Michael S. Denison. 2000. Application of a human ovarian cell bioassay for the detection and analysis of estrogen-toxicant interaction. Organohalogen Compounds. 49:338-341.
  • Rogers, Jane M. and Michael S. Denison. 2000. Recombinant cell bioassays for endocrine disruptors: Development of a stably transfected human ovarian cell line for the detection of estrogenic and anti-estrogenic chemicals. In Vitro & Molecular Toxicology.   13(1):67-82.
  • Seidel, Shawn D., Violet Li, Greg M. Winters, W.J. Rogers, Eugenio I. Martinez, and Michael S. Denison. 2000. Ah receptor-based chemical screening bioassays: application and limitations for the detection of Ah receptor agonists. Toxicological Sciences.   55(1):107-115.
  • Shan, Guomin, James R. Sanborn, Douglas S. Gilman, Scott R. Nagy, Shirley J. Gee, Donald W. Stoutamire, Roger S. Mercer, A. Daniel Jones, Larry H. Stanker, Michael S. Denison, and Bruce D. Hammock. 2000. Surrogates for dioxin analyses: analytical, ELISA and toxicological aspects. Organohalogen Compounds. 45:188-191.
  • Williams, Susanne N., Hsueh Shih, Denis K. Guenette, William Brackney, Michael S. Denison, George V. Pickwell, and Linda C. Quattrochi. 2000. Comparative studies on the effects of green tea extracts and individual tea catechins on human CYP1A gene expression. Chemico-Biological Interactions.   128(3):211-229.
  • Ziccardi, Michael H., Ian A. Gardner, and Michael S. Denison. 2000. Development and Modification of a Recombinant Cell Bioassay to Directly Detect Halogenated and Polycyclic Aromatic Hydrocarbons in Serum. Toxicological Sciences.   54(1):183-193.
1999
  • Denison, Michael S., Shawn D. Seidel, Michael H. Ziccardi, William J. Rogers, David J. Brown, and George C. Clark. 1999. Ah receptor-based bioassays for dioxins and related chemicals: applications and limitations. Organohalogen Compounds. 40:27-30.
  • Levine, Steven L., James T. Oris, and Michael S. Denison. 1999. Modulation of CYP1A expression in rainbow trout by a technical grade formulation of propriconazole. Environmental Toxicology and Chemistry.   18(11):2565-2573.
1998
  • Besselink, Harrie T., Michael S. Denison, Mark E. Hahn, Sibel I. Karchner, A. Dick Vethaak, Jan H. Koeman, and Abraham Brouwer. 1998. Low inducibility of CYPIA activity by polychlorinated biphenyls (PCBs) in flounder (Platichthys flesus): Characterization of the Ah receptor and the role of CYPIA inhibition. Toxicological Sciences.   43(2):161-171.
  • Denison, Michael S. and Sharon Heath-Pagliuso. 1998. The Ah Receptor: A Regulator of the biochemical and toxicological actions of structurally diverse chemicals. Bulletin of Environmental Contamination and Toxicology.   61:557-568.
  • Denison, Michael S., D. Phelan, and C.J. Elferink. 1998. The Ah receptor signal transduction pathway. In: Xenobiotics, Toxicant-Receptor Interactions. Taylor and Francis, Philadelphia, PA. pp.3-33.
  • Denison, Michael S., D. Phelan, Greg M. Winters, and Michael H. Ziccardi. 1998. Carbaryl, a carbamate insecticide, is a ligand for the hepatic Ah (dioxin) receptor. Toxicology and Applied Pharmacology.   152(2):406-414.
  • Heath-Pagliuso, Sharon, William J. Rogers, Kathryn Tullis, Shawn D. Seidel, Peter H. Cenijn, Abraham Brouwer, and Michael S. Denison. 1998. Activation of the Ah receptor by tryptophan and tryptophan metabolites. Biochemistry.   37(33):11508-11515.
  • Phelan, D., Greg M. Winters, W.J. Rogers, J.C. Lam, and Michael S. Denison. 1998. Activation of the Ah receptor signal transduction pathway by bilirubin and biliverdin. Archives of Biochemistry and Biophysics.   357(1):155-163.
1997
  • Murk, Albertinka J., Pim EG Leonards, Astrid S. Bulder, Arjen S. Jonas, Marcel JC Rozemeijer, Michael S. Denison, Jan H. Koeman, and Abraham Brouwer. 1997. The CALUX (Chemical-activated Luciferase Expression) Assay Adapted and Validated for Measuring TCDD Equivalents in Blood Plasma. Environmental Toxicology and Chemistry.   16(8):1583-1589.
  • Murk, T., Juliette Legler, Michael S. Denison, John P. Giesy, C.J. van der Guchte, and Abraham Brouwer. 1997. Chemical-activated luciferase expression (CALUX): A novel in vitro bioassay for Ah-receptor active compounds in sediments and pore water. Fundamental and Applied Toxicology.   33:149-160.
  • Richter, C.A., John P. Giesy, V.L. Tieber, and Michael S. Denison. 1997. An in vitro Rainbow Trout cell bioassay for AhR-mediated toxins. Environmental Toxicology and Chemistry.   16:543-550.
  • Washburn, Barbara Shayne, Kathleen S. Rein, Daniel G. Baden, Patrick J. Walsh, David E. Hinton, Kathryn Tullis, and Michael S. Denison. 1997. Brevetoxin-6 (PbTx-6), a nonaromatic marine neurotoxin, is a ligand of the aryl hydrocarbon receptor. Archives of Biochemistry and Biophysics.   343(2):149-156.
  • Ziccardi, Michael H., William J. Rogers, A.J. Schecter, Olaf Papke, and Michael S. Denison. 1997. Direct detection of dioxins and related chemicals in small quantities of human serum using a recombinant cell bioassay. Organohalogen Compounds. 31:215-218.
1996
  • Denison, Michael S., William J. Rogers, M. Fair, Michael H. Ziccardi, George C. Clark, Albertinka J. Murk, and Abraham Brouwer. 1996. Applications of the CALUX bioassay system for the detection of dioxin-like chemicals (Ah receptor ligands) in whole serum samples in extracts from commercial and consumer products. Organohalogen Compounds. 27:280-284.
  • Garrison, P.A., Kathryn Tullis, Jac MMJG Aarts, Abraham Brouwer, John P. Giesy, and Michael S. Denison. 1996. Species-specific Recombinant Cell Lines as Bioassay Systems for the Detection of 2,3,7,8-Tetrachlorodibenzo-p-dioxin-like chemicals. Fundamental and Applied Toxicology.   30(2):194-203.
  • Gebremichael, Assefa, Kathryn Tullis, Michael S. Denison, Jeffrey M. Cheek, and Kent E. Pinkerton. 1996. Ah-receptor-dependent modulation of gene expression by aged and diluted sidestream cigarette smoke. Toxicology and Applied Pharmacology.   141(1):76-83.
  • Murk, Albertinka J., Juliette Legler, Michael S. Denison, John P. Giesy, C.J. van der Guchte, and Abraham Brouwer. 1996. Chemical-activated Luciferase Gene Expression (CALUX): A Novel In Vitro Bioassay for Ah Receptor Active Compounds in Sediments and Pore Water. Fundamental and Applied Toxicology.   33(1):149-160.
  • Sanderson, J Thomas, Jac MMJG Aarts, Abraham Brouwer, Kenneth L. Froese, Michael S. Denison, and John P. Giesy. 1996. Comparison of Ah Receptor-Mediated Luciferase and Ethoxyresorufin-O-deethylase Induction in H4IIE Cells: Implications for Their Use as Bioanalytical Tools for the Detection of Polyhalogenated Aromatic Hydrocarbons. Toxicology and Applied Pharmacology.   137(2):316-325.
  • Villalobos, Sergio A., Michael J. Anderson, Michael S. Denison, David E. Hinton, Kathryn Tullis, Ian M. Kennedy, A. Daniel Jones, Daniel PY Chang, Gosu Yang, and Peter B. Kelly. 1996. Dioxin-like properties of a trichloroethylene combustion-generated aerosol. Environmental Health Perspectives. 104(7):734-743.
  • Walsh, Agnes A., Kathryn Tullis, Robert H. Rice, and Michael S. Denison. 1996. Identification of a novel cis-acting negative regulatory element affecting expression of the CYP1A1 gene in rate epidermal cells. Journal of Biological Chemistry.   271(37):22746-22753.
1995
  • Newsted, J.L., John P. Giesy, Gerald T. Ankley, Donald E. Tillitt, R.A. Crawford, J.L. Gooch, Paul D. Jones, and Michael S. Denison. 1995. Development of toxic equivalency factors for PCB congeners and the assessment of TCDD and PCB mixtures in rainbow trout. Environmental Toxicology and Chemistry.   14(5):861-871.