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National Institute of Environmental Health Sciences

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Your Environment. Your Health.

Person Details: Jennifer J. Schlezinger

Superfund Research Program

Jennifer J. Schlezinger

Boston University
Department of Environmental Health
Sherr Lab, R4
715 Albany Street
Boston, Massachusetts 02118
Phone: 617-358-1708
Fax: 617-638-6463
Email: jschlezi@bu.edu

Projects

Research Briefs

Patents

Hazardous Waste Sites

New Bedford Harbor

  • Boston University: Environmental PPARγ Pathway Activators: Multifaceted Metabolic Disruptors Impacting Adipose and Bone Homeostasis

Publications

2022

  • Sen P, Qadri S, Luukkonen PK, Ragnarsdottir O, McGlinchey A, Jantti S, Juuti A, Arola J, Schlezinger JJ, Webster TF, Oresic M, Yki-Jarvinen H, Hyotylainen T. 2022. Exposure to environmental contaminants is associated with altered hepatic lipid metabolism in non-alcoholic fatty liver disease. J Hepatol 76(2):doi:10.1016/j.jhep.2021.09.039 PMID:34627976

2021

  • Kim S, Reed E, Monti S, Schlezinger JJ. 2021. A data-driven transcriptional taxonomy of adipogenic chemicals to identify white and brite adipogens. Environ Health Perspect 129(7):77006. doi:10.1289/EHP6886 PMID:34323617 PMCID:PMC8320370
  • Schlezinger JJ, Hyotylainen T, Sinjoja T, Moore Boston C, Puckett H, Oliver J, Heiger-Bernays WJ, Webster TF. 2021. Perfluorooctanoic acid induces liver and serum dyslipidemia in humanized PPAR(alpha) mice fed an American diet. Toxicol Appl Pharmacol 426:115644. doi:10.1016/j.taap.2021.115644 PMID:34252412 PMCID:PMC8338894

2020

  • Andrews FV, Kim S, Edwards L, Schlezinger JJ. 2020. Identifying adipogenic chemicals: Disparate effects in 3T3-L1, OP9 and primary mesenchymal multipotent cell models. Toxicol In Vitro 67:12. doi:10.1016/j.tiv.2020.104904 PMID:32473317
  • Crawford KA, Clark BW, Heiger-Bernays WJ, Karchner SI, Hahn ME, Nacci DE, Schlezinger JJ. 2020. Tributyltin disrupts fin development in Fundulus heteroclitus from both PCB-sensitive and resistant populations: Investigations of potential interactions between AHR and PPARy. Aquat Toxicol 218:105334. doi:10.1016/j.aquatox.2019.105334 PMID:31743820 PMCID:PMC6935467
  • de la Rosa R, Schlezinger JJ, Smith MT, Webster TF. 2020. Application of generalized concentration addition to predict mixture effects of glucocorticoid receptor ligands. Toxicol Vitro 69(7):104975. doi:10.1016/j.tiv.2020.104975 PMID:32858110 PMCID:PMC7594746
  • Kim S, Rabhi N, Blum BC, Hekman R, Wynne K, Emili A, Farmer S, Schlezinger JJ. 2020. Triphenyl phosphate is a selective PPARy modulator that does not induce brite adipogenesis in vitro and in vivo. Arch Toxicol 17:3087-3103. doi:10.1007/s00204-020-02815-1 PMID:32683515
  • Schlezinger JJ, Puckett H, Nielsen OG, Heiger-Bernays WJ, Webster TF. 2020. Perfluorooctanoic acid activates multiple nuclear receptor pathways and skews expression of genes regulating cholesterol homeostasis in liver of humanized PPAR alpha mice fed an American diet. Toxicol Appl Pharmacol 405:115204. doi:10.1016/j.taap.2020.115204 PMID:32822737 PMCID:PMC7503133

2019

  • Crawford KA, Clark BW, Heiger-Bernays WJ, Karchner SI, Claus Henn B, Griffith KN, Howes BL, Schlezinger DR, Hahn ME, Nacci DE, Schlezinger JJ. 2019. Altered lipid homeostasis in a PCB-resistant Atlantic killifish (Fundulus heteroclitus) population from New Bedford Harbor, MA, U.S.A. Aquat Toxicol 210:30-43. doi:10.1016/j.aquatox.2019.02.011 PMID:30822701 PMCID:PMC6544361
  • Edwards L, Watt J, Webster TF, Schlezinger JJ. 2019. Assessment of total, ligand-induced peroxisome proliferator activated receptor gamma ligand activity in serum. Environ Health 18(45):doi:10.1186/s12940-019-0486-2 PMID:31072366 PMCID:PMC6506953

2018

  • Kim S, Li A, Monti S, Schlezinger JJ. 2018. Tributyltin induces a transcriptional response without a brite adipocyte signature in adipocyte models. Arch Toxicol 1-16. doi:10.1007/s00204-018-2268-y PMID:30027469
  • Narasimhan S, Zulick ES, Novikov O, Parks A, Schlezinger JJ, Wang Z, Laroche F, Feng H, Mulas F, Monti S, Sherr DH. 2018. Towards resolving the pro- and anti-tumor effects of the aryl hydrocarbon receptor. Int J Mol Sci 19:24. doi:10.3390/ijms19051388 PMID:29735912 PMCID:PMC5983651
  • Watt J, Baker AH, Meeks B, Pajevic PD, Morgan EF, Gerstenfeld LC, Schlezinger JJ. 2018. Tributyltin induces distinct effects on cortical and trabecular bone in female C57Bl/6J mice. Journal of Cellular Physiology 233:7007-7021. doi:10.1002/jcp.26495 PMID:29380368

2017

  • Kassotis CD, Masse L, Kim S, Schlezinger JJ, Webster TF, Stapleton HM. 2017. Characterization of adipogenic chemicals in three different cell culture systems: Implications for reproducibility based on cell source and handling. Sci Rep 7(42104):doi:10.1038/srep42104 PMID:28176856 PMCID:PMC5296734

2016

  • Auerbach SS, Filer D, Reif DM, Walker V, Blumberg B, Clegg D, Holloway A, Schlezinger JJ, Srinivasan S, White M, Svoboda D, Judson RR, Bucher JR, Thayer KA. 2016. Identifying environmental chemicals to test for obesity and diabetes outcomes: clues from ToxCast high throughput screening data. Environ Health Perspect 128:1141-1154.
  • Bolt AM, Grant MP, Flores Molina M, Plourde D, Kelly AD, Negro Silva LF, Lemaire M, Schlezinger JJ, Mwale F, Mann K. 2016. Tungsten promotes sex-specific adipogenesis in the bone by altering differentiation of bone marrow-resident mesenchymal stromal cells. Toxicol Sci 150(2):333-346. doi:10.1093/toxsci/kfw008 PMID:26865663 PMCID:PMC4900133
  • Watt J, Webster TF, Schlezinger JJ. 2016. Generalized concentration addition modeling predicts mixture effects of environmental PPARγ agonists. Toxicol Sci 153(1):18-27. doi:10.1093/toxsci/kfw100 PMID:27255385 PMCID:PMC5013877

2015

  • Baker AH, Watt J, Huang CK, Gerstenfeld LC, Schlezinger JJ. 2015. Tributyltin engages multiple nuclear receptor pathways and suppresses osteogenesis in bone marrow multipotent stromal cells. Chem Res Toxicol 28(6):1156-1166. doi:10.1021/tx500433r PMID:25932594 PMCID:PMC4737589
  • Bragdon B, Burns R, Baker AH, Belkina AC, Morgan EF, Denis GV, Gerstenfeld LC, Schlezinger JJ. 2015. Intrinsic sex-linked variations in osteogenic and adipogenic differentiation potential of bone marrow multipotent stromal cells. Journal of Cellular Physiology 230(2):296-307. doi:10.1002/jcp.24705 PMID:24962433 PMCID:PMC4317374
  • Watt J, Schlezinger JJ. 2015. Structurally-diverse, PPARγ-activating environmental toxicants induce adipogenesis and suppress osteogenesis in bone marrow mesenchymal stromal cells. Toxicology 331:66-77. doi:10.1016/j.tox.2015.03.006 PMID:25777084 PMCID:PMC4406869

2014

  • Lowe MM, Mold JE, Kanwar B, Huang Y, Louie A, Pollastri MP, Wang C, Patel G, Franks DG, Schlezinger JJ, Sherr DH, Silverstone AE, Hahn ME, McCune JM. 2014. Identification of cinnabarinic acid as a novel endogenous aryl hydrocarbon receptor ligand that drives IL-22 production. PLoS One 9(2):15. doi:10.1371/journal.pone.0087877 PMID:24498387 PMCID:PMC3912126
  • Parks A, Pollastri MP, Hahn ME, Stanford EA, Novikov O, Franks DG, Haigh SE, Narasimhan S, Ashton TD, Hopper TG, Kozakov D, Beglov D, Vajda S, Schlezinger JJ, Sherr DH. 2014. In silico identification of an aryl hydrocarbon receptor antagonist with biological activity in vitro and in vivo. Mol Pharmacol 86(5):593-608. doi:10.1124/mol.114.093369 PMID:25159092 PMCID:PMC4201140
  • Pillai HK, Fang M, Beglov D, Kozakov D, Vajda S, Stapleton HM, Webster TF, Schlezinger JJ. 2014. Ligand binding and activation of PPARγ by Firemaster® 550: effects on adipogenesis and osteogenesis in vitro. Environ Health Perspect 122(11):1225-1232. doi:10.1289/ehp.1408111 PMID:25062436 PMCID:PMC4216168
  • Simmons AL, Schlezinger JJ, Corkey BE. 2014. What are we putting in our food that is making us fat? Food additives, contaminants, and other putative contributors to obesity. Curr Obes Rep 3(2):273-285. doi:10.1007/s13679-014-0094-y PMID:25045594 PMCID:PMC4101898

2012

  • Handley-Goldstone HM, Tokunaga S, Schlezinger JJ, Goldstone JV, Stegeman JJ. 2012. EZR1: A novel family of highly expressed retroelements induced by TCDD and regulated by a NF-kapa B-like factor in embroyos of zebrafish (Danio rerio). Zebrafish 9:15-25. doi:10.1089/zeb.2011.0722 PMID:22356696 PMCID:PMC3308714
  • Springer C, Dere E, Hall SJ, McDonnell EV, Roberts SC, Butt CM, Stapleton HM, Watkins DJ, McClean MD, Webster TF, Schlezinger JJ, Boekelheide K. 2012. Rodent thyroid, liver, and fatal testis toxicity of the monoester metabolite of Bis-(2-ethylhexyl) Tetrabromophthalate (TBPH), a novel brominated flame retardant present in indoor dust. Environ Health Perspect 120:1711-1719. doi:10.1289/ehp.1204932 PMID:23014847 PMCID:PMC3548273

2010

  • Bissonnette SL, Haas A, Mann KK, Schlezinger JJ. 2010. The role of CaMKII in calcium-activated death pathways in bone marrow B cells. Toxicol Sci 118(1):108-118. doi:10.1093/toxsci/kfq256 PMID:20810541 PMCID:PMC2955217
  • Howard G, Schlezinger JJ, Hahn ME, Webster TF. 2010. Generalized concentration addition predicts joint effects of aryl hydrocarbon receptor agonists with partial agonists and competitive antagonists. Environ Health Perspect 118(5):666-672. doi:10.1289/ehp.0901312 PMID:20435555 PMCID:PMC2866683
  • Teague J, Ryu H, Kirber M, Sherr DH, Schlezinger JJ. 2010. Proximal events in 7,12-dimethylbenz a anthracene-induced, stromal cell-dependent bone marrow B cell apoptosis: stromal cell-B cell communication and apoptosis signaling. J Immunol 185:3369-3378. doi:10.4049/jimmunol.0902541 PMID:20720205 PMCID:PMC2933279

2007

  • Howard G, Schlezinger JJ, Webster TF. 2007. Interactions of TCDD with AhR partial agonists and a competitive antagonist: implications for TEFs. Organohalogen Compounds 69:1065-1068.
  • Schlezinger JJ, Emberley JK, Sherr DH, Bissonnette SL. 2007. An L-tyrosine derivative and PPARγ agonist, GW7845, activates a multi-faceted capase cascade in bone marrow B cells. Toxicol Sci 98(1):125-36. PMID:17400580

2006

  • Allan LL, Schlezinger JJ, Shansab M, Sherr DH. 2006. CYP1A1 in polycyclic aromatic hydrocarbon-induced B lymphocyte growth suppression. Biochem Biophys Res Commun 342(1):227-235. PMID:16472762
  • Schlezinger JJ, Emberley JK, Sherr DH. 2006. Activation of multiple mitogen-activated protein kinases in pro/pre-B cells by GW7845, a peroxisome proliferator-activated receptor gamma agonist, and their contribution to GW7845-induced apoptosis. Toxicol Sci 92(2):433-44. PMID:16672323
  • Schlezinger JJ, Struntz WD, Goldstone JV, Stegeman JJ. 2006. Uncoupling of cytochrome P450 1A and stimulation of reactive oxygen species production by co-planar polychlorinated biphenyl congeners. Aquat Toxicol 77(4):422-432. PMID:16500718

2005

  • Ryu H, Emberley JK, Schlezinger JJ, Allan LL, Na S, Sherr DH. 2005. Environmental chemical-induced bone marrow B cell apoptosis: death receptor-independent activation of a caspase-3 to caspase-8 pathway. Mol Pharmacol 68(4):1087-1096. PMID:16014577

2004

  • Schlezinger JJ, Howard G, Hurst CH, Emberley JK, Waxman DJ, Webster TF, Sherr DH. 2004. Environmental and endogenous peroxisome proliferator-activated receptor gamma agonists induce bone marrow B cell growth arrest and apoptosis: Interactions between mono(2-ethylhexyl)phthalate, 9-cis-retinoic acid, and 15-Deoxy-Delta(12,14)-prostaglandin J(2). J Immunol 173(5):3165-3177. PMID:15322177

2003

  • Allan LL, Mann KK, Matulka RA, Ryu H, Schlezinger JJ, Sherr DH. 2003. Bone marrow stromal-B cell interactions in polycyclic aromatic hydrocarbon-induced pro/pre-B cell apoptosis. Toxicol Sci 76(2):357-365. PMID:14514961
  • Ryu H, Mann KK, Schlezinger JJ, Jensen B, Sherr DH. 2003. Environmental chemical-induced pro/pre-B cell apoptosis: analysis of c-Myc, p27(Kipl), and p21(WAF1) reveals a death pathway distinct from clonal deletion. J Immunol 170(10):4897-4907. PMID:12734332
  • Takai Y, Canning J, Perez GI, Pru JK, Schlezinger JJ, Sherr DH, Kolesnick RN, Yuan J, Flavell RA, Korsmeyer SJ, Tilly JL. 2003. Bax, caspase-2, and caspase-3 are required for ovarian follicle loss caused by 4-vinylcyclohexene diepoxide exposure of female mice in vivo. Endocrinology 144(1):69-74. PMID:12488331

2002

  • Schlezinger JJ, Jensen B, Mann KK, Ryu H, Sherr DH. 2002. Peroxisome proliferator-activated receptor gamma-mediated NF-kappa B activation and apoptosis in pre-B cells. J Immunol 169(12):6831-6841. PMID:12471115

2001

  • Mann KK, Doerre S, Schlezinger JJ, Sherr DH, Quadri SA. 2001. The role of NF-kB as a survival factor in environmental chemical-induced preB cell apoptosis. Mol Pharmacol 59(2):302-309. PMID:11160867
  • Matikainen T, Perez GI, Jurisicova A, Pru JK, Schlezinger JJ, Ryu H, Laine J, Sakai T, Korsmeyer SJ, Casper RF, Sherr DH, Tilly JL. 2001. Aromatic hydrocarbon receptor-driven Bax gene expression is required for premature ovarian failure caused by biohazardous environmental chemicals. Nat Genet 28(4):355-360. PMID:11455387

2000

  • Schlezinger JJ, Blickarz CE, Mann KK, Doerre S, Stegeman JJ. 2000. Identification of NF-kB in the marine fish Stenotomus chrysops and examination of its activation by aryl hydrocarbon receptor agonists. Chem Biol Interact 126(2):137-157. PMID:10862814
  • Schlezinger JJ, Keller J, Verbrugge LA, Stegeman JJ. 2000. 3,3',4,4'-Tetrachlorobiphenyl oxidation in fish, bird and reptile species: relationship to cytochrome P450 1A inactivation and reactive oxygen production. Comp Biochem Physiol C Toxicol Pharmacol 125(3):273-286. PMID:11790349
  • Schlezinger JJ, Stegeman JJ. 2000. Dose and inducer-dependent induction of cytochrome P450 1A in endothelia of the eel, including in the swimbladder rete mirabile, a model microvascular structure. Drug Metab Dispos 28(6):701-708. PMID:10820144
  • Schlezinger JJ, Stegeman JJ. 2000. Induction of cytochrome P450 1A in the American Eel by model halogenated and non-halogenated aryl hydrocarbon receptor agonists. Aquat Toxicol 50(4):375-386. PMID:10967399

1999

  • Schlezinger JJ, White RD, Stegeman JJ. 1999. Oxidative inactivation of cytochrome P450 1A stimulated by 3,3',4,4'-tetrachlorobiphenyl: production of reactive oxygen by vertebrate CYP1As. Mol Pharmacol 56(3):588-597. PMID:10462547

1998

  • Schlezinger JJ, Parker C, Zeldin DC, Stegeman JJ. 1998. Arachidonic acid metabolism in the marine fish Stenotomus chrysops (scup) and the effects of cytochrome P4501A inducers. Arch Biochem Biophys 353(2):265-275. PMID:9606961
  • Schlezinger JJ, Struntz WD, Stegeman JJ. 1998. Cytochrome P4501A (CYP1A) and planar halogenated hydrocarbons (pHAH): Oxidative inactivation and reactive oxygen production. In: Proceedings of the 37th Society of Toxicology Annual Meeting, March 1-5. Seattle, WA.

1997

  • Schlezinger JJ, White RD, Stegeman JJ. 1997. Inactivation of cytochrome P4501A1 by 3,3',4,4'-tetrachlorobiphenyl and the formation of reactive oxygen species. In: Proceedings of the Society for Environmental Toxicology and Chemistry Annual Meeting. San Francisco, CA.

1996

  • Schlezinger JJ, White RD, Stegeman JJ. 1996. 3,3',4,4'-tetrachlorobiphenyl stimulates release of active oxygen from hepatic microsomes and the oxidative inactivation of cytochrome P4501A1. In: Proceedings of the 11th International Symposium on Microsomes and Drug Oxidations. pp.192.
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