Project Summary (2000-2005)

The objective of the Biostatistics and Data Management Core is to enhance program interactivity and scientific quality by providing the SBRP full access to the biostatistical expertise and data management resources at Dartmouth. The Dartmouth projects involve in vitro and whole animal experimental epidemiologic data with sophisticated biomarker measures of individual exposure and genetic markers and multilevel clustered sampling in ecological and geochemical surveys. Sound statistical methodology and data management are essential for the successful conduct of these projects. Economies of scale are achieved by sharing the support of statistical personnel, specialized software, and computing resources within the Core. These statistical resources are utilized by project personnel in critical phases of design and analysis of their experiments. Core personnel also develop enhanced statistical methods necessary to study the relationship between low to moderate arsenic exposures and cancer based on the use of multiple biomarkers of exposure.