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Study Information
Study Attribute Value
CEBS Accession Number: 002-01105-0001-0000-0
Chemical Name: 1-(2,6,6-Trimethyl-2-cyclohexene-1-yl)-1-penten-3-one
CASRN: 7779-30-8
NTP Study Type: Genetic Toxicology - Bacterial Mutagenicity
NTP Study ID: 135512
Vehicle Control: Dimethyl Sulfoxide
Study Result: Negative

Table Instructions and Notes:
You are currently viewing the results for this Salmonella study's detailed data.
Individual strain data is presented as mean ± standard error.
Abbreviations are noted at bottom of page.
Trial summary calls are shown in parentheses.
Standard NTP Protocol

Strain: TA100
Dose No Activation
(Negative) 		No Activation
(Negative) 		No Activation
(Negative) 		30% RLI
(Negative) 		30% RLI
(Negative) 		30% HLI
(Equivocal) 		30% HLI
(Negative) 		10% RLI
(Negative) 		10% HLI
(Negative)
Protocol Preincubation Preincubation Preincubation Preincubation Preincubation Preincubation Preincubation Preincubation Preincubation
ug/Plate Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM 
 0         
 115 11.3 161 1.3 106 17.1 126 10.4 212 13.6 122 8.7 173 11.7 115 9.9 142 5.8 
 0.33      
 121 10.1 
 0.1       
 154 2.8 
 0.3       
 144 8.6 
1         
 108 20.7 150 2.3 120 1.7 195 2.3 126 14.2 122 15.2 
3.3       
 119 10.5 153 8.7 118 7.5 195 2.3 135 7.8 137 2 
10         
 112 13.4 151 8.1 116 18.4 121 9.8 199 5.4 129 7.2 140 1.8 126 4.3 
33         
 85 s 2.7 98 2.1 133 6.7 204 1.5 136 8.6 164 7.8 132 2 140 6.9 
100         
 66 s 7.5 94 s 3.7 133 7 201 2.3 140 13.1 195 8.2 140 19 148 4 
333         
 114 s 6.7 167 1.5 129 14.6 89 s 7.8 117 s 6.7 
500         
 97 s 13.3 
667         
 97 s 4 
1000         
 76 s 8.2 108 s 18.4
Positive Control 523 9.3 519 33 508 29.7 732 13.7 735 14.7 384 9 715 11 1201 55 685 30.2

Strain: TA1535
Dose No Activation
(Negative) 		No Activation
(Negative) 		No Activation
(Negative) 		No Activation
(Negative) 		30% RLI
(Negative) 		30% HLI
(Negative) 		30% HLI
(Negative) 		30% HLI
(Negative) 		10% RLI
(Negative) 		10% HLI
(Negative)
Protocol Preincubation Preincubation Preincubation Preincubation Preincubation Preincubation Preincubation Preincubation Preincubation Preincubation
ug/Plate Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM 
 0         
 11 1.2 9 2.7 13 1.2 12 1.9 11 4.1 13 1.8 10 1.3 11 .9 12 1.7 10 1.8 
 0.033     
 7 1.7 
 0.33      
 12 3.2 10 1.7 10 1.9 15 3.5 
 0.1       
 13 2.9 
1         
 7 1.2 7 1.5 9 .3 11 1.7 13 1.7 10 .9 13 .7 
3.3       
 8 1.3 5 1.5 12 .9 9 1 13 1.3 12 0 14 1.5 10 3.1 11 2.4 
10         
 8 1.2 8 s 1.7 7 .9 12 3.6 13 1.5 9 1.5 10 3.3 15 1.9 11 .9 9 3.3 
33         
 8 s 1.5 6 s .9 13 1 11 1.5 11 1.5 12 2.2 17 3 13 .7 9 .3 
100         
 7 s 1.5 9 1.2 13 1.3 12 2.3 5 s 1.5 14 1.8 11 1.9 11 .3 
333         
 6 s 1.2 8 s 4.5 5 s 1.7 11 s 3.7 11 s 1.5 
1000         
 10 s .7
Positive Control 305 11.6 187 11.3 247 19 340 23.7 157 11.3 55 4.4 66 2 83 4.4 201 6.1 57 1.2

Strain: TA97
Dose No Activation
(Negative) 		No Activation
(Negative) 		No Activation
(Negative) 		No Activation
(Negative) 		30% RLI
(Negative) 		30% HLI
(Negative) 		10% RLI
(Negative) 		10% HLI
(Negative)
Protocol Preincubation Preincubation Preincubation Preincubation Preincubation Preincubation Preincubation Preincubation
ug/Plate Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM 
 0         
 136 10.2 153 7.9 107 1.3 141 2.7 171 7 146 5.5 167 2.3 165 5.8 
 0.033     
 118 5.5 
 0.33      
 141 3.5 130 5.4 142 6.4 
 0.1       
 108 6.9 
1         
 134 4.1 139 6.8 122 9.1 142 6.7 157 9.8 160 5.4 
3.3       
 127 7.1 132 4.1 95 3.5 160 1.3 178 11.6 166 5.1 170 1.5 
10         
 115 14.4 96 s 5 107 14 149 .9 164 9.4 159 6 178 15.9 175 .9 
33         
 61 s 2.9 75 s 4.2 141 9.9 181 8.3 160 12.2 187 12.3 180 7.8 
100         
 46 s 5.3 127 s 4.7 191 7.9 190 5 157 2.2 183 8.8 
333         
 132 s 7 104 43.4 125 s 11.7 137 s 8.2 
1000         
 51 s 1.3
Positive Control 322 8.5 577 115.8 1417 98.7 1288 457.9 826 24.4 1089 49.2 2084 158.1 1144 47.8

Strain: TA98
Dose No Activation
(Negative) 		No Activation
(Negative) 		30% RLI
(Negative) 		30% RLI
(Negative) 		30% HLI
(Equivocal) 		30% HLI
(Negative) 		10% RLI
(Negative) 		10% HLI
(Negative)
Protocol Preincubation Preincubation Preincubation Preincubation Preincubation Preincubation Preincubation Preincubation
ug/Plate Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM 
 0         
 20 1.8 16 1.5 25 2.9 28 2.8 20 2.6 30 4.6 25 2.3 21 2.7 
 0.33      
 14 1.2 
1         
 15 1.2 20 1.5 30 .9 22 4 23 4.1 
3.3       
 13 2 16 3.8 33 2.9 23 .6 26 2.3 
10         
 15 2.3 20 4.1 19 .9 25 2 20 1.5 28 4.2 26 2.4 
33         
 7 1.2 9 1.8 22 2.3 24 2.9 25 1.2 29 4.8 29 3.1 24 2.3 
100         
 6 s 2.5 9 .9 25 3.2 31 5.6 31 1.2 39 3.5 19 1.2 37 1.7 
333         
 14 s .9 40 .3 27 1.9 14 s 3.3 19 s 3.5 
500         
 22 s 4.8 
667         
 15 s 5.5 
1000         
 11 s .3 20 s 3.1
Positive Control 261 4.1 316 18.6 383 5.6 391 10.9 466 7.6 652 20.8 603 30.9 719 23.2

Abbreviations:
RLI = induced male Sprague Dawley rat liver S9
HLI = induced male Syrian hamster liver S9
s = Slight Toxicity; p = Precipitate; x = Slight Toxicity and Precipitate; t = Toxic;