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Study Information
Study Attribute Value
CEBS Accession Number: 002-02099-0001-0000-3
Chemical Name: Dodecylbenzenesulfonic acid, sodium salt
CASRN: 25155-30-0
NTP Study Type: Genetic Toxicology - Bacterial Mutagenicity
NTP Study ID: 761777
Vehicle Control: Dimethyl Sulfoxide
Study Result: Negative

Table Instructions and Notes:
You are currently viewing the results for this Salmonella study's detailed data.
Individual strain data is presented as mean ± standard error.
Abbreviations are noted at bottom of page.
Trial summary calls are shown in parentheses.
Standard NTP Protocol

Strain: TA100
Dose No Activation
(Negative) 		No Activation
(Negative) 		No Activation
(Negative) 		30% RLI
(Negative) 		30% HLI
(Negative) 		10% RLI
(Negative) 		10% HLI
(Negative)
Protocol Preincubation Preincubation Preincubation Preincubation Preincubation Preincubation Preincubation
ug/Plate Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM 
 0         
 143 4.3 133 3.8 113 5.2 140 3.9 136 2.9 145 2.2 122 11.2 
10         
 118 .6 
33         
 156 10.7 129 7.6 112 1.7 146 6.1 143 14.2 145 8.7 138 6.5 
100         
 158 3.8 130 8.1 115 6 159 4.2 152 14.8 133 3.2 124 6.9 
333         
 157 7.2 118 7.9 114 .6 135 16.1 152 6.1 136 6.4 111 3.2 
1000         
 135 6.1 93 12.3 113 2.8 142 3.7 145 12.3 137 11.8 107 11.7 
3333         
 34 s 1.8 31 s 6.4 129 12 126 20.6 92 5.3 106 8.2
Positive Control 876 24 1009 16.5 902 47.9 501 36.2 723 5.8 288 3.6 400 48.5

Strain: TA1535
Dose No Activation
(Negative) 		No Activation
(Negative) 		No Activation
(Negative) 		30% RLI
(Negative) 		30% HLI
(Negative) 		10% RLI
(Negative) 		10% HLI
(Negative)
Protocol Preincubation Preincubation Preincubation Preincubation Preincubation Preincubation Preincubation
ug/Plate Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM 
 0         
 18 4.7 14 2.3 10 .9 15 .7 0 0 11 2.1 13 3.2 
 0         
 18 4.7 14 2.3 10 .9 15 .7 0 0 11 2.1 13 3.2 
10         
 11 .6 
33         
 17 2 13 2.7 11 .6 12 2 12 1.8 10 2.3 10 2.5 
100         
 15 1.5 15 1.3 11 2.2 11 2 15 1.5 9 1.5 7 1.2 
333         
 16 1.7 14 1.9 9 .6 14 1.5 14 2.8 9 .3 12 3.2 
1000         
 12 1.9 14 1.2 9 .9 13 3.1 17 2.3 6 1.5 6 .6 
3333         
 9 2.2 6 s 3.2 12 4 13 .3 4 .6 5 1.7
Positive Control 1159 13.2 941 34.4 819 23.7 230 9.5 557 45.4 86 4.6 100 2.1

Strain: TA97
Dose No Activation
(Negative) 		No Activation
(Negative) 		No Activation
(Negative) 		30% RLI
(Negative) 		30% HLI
(Negative) 		10% RLI
(Negative) 		10% HLI
(Negative)
Protocol Preincubation Preincubation Preincubation Preincubation Preincubation Preincubation Preincubation
ug/Plate Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM 
 0         
 113 2.6 136 10.8 122 3.7 184 1.5 128 1.8 169 4 135 5.1 
10         
 115 2 
33         
 123 10 131 2.9 113 3.8 172 8.7 153 5.4 156 3.3 132 14.1 
100         
 126 2.6 128 7.6 113 4.9 180 2.2 143 7.8 146 16.8 135 7.5 
333         
 111 7.6 103 6.5 111 1.9 165 19.3 141 5.1 170 8.2 152 6.2 
1000         
 109 2.3 124 9 114 2.7 199 7.6 124 7 136 13.9 125 8.2 
3333         
 76 s 1.2 78 s 5.8 114 22.1 100 7 95 5.4 111 10.7
Positive Control 399 15.3 300 19.2 250 10.2 777 21.6 945 16.8 363 17.5 333 16.1

Strain: TA98
Dose No Activation
(Negative) 		No Activation
(Negative) 		No Activation
(Negative) 		30% RLI
(Negative) 		30% HLI
(Negative) 		10% RLI
(Negative) 		10% HLI
(Negative)
Protocol Preincubation Preincubation Preincubation Preincubation Preincubation Preincubation Preincubation
ug/Plate Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM 
 0         
 22 2 21 4.5 15 .7 27 2.3 26 1.2 21 4.2 28 .3 
10         
 14 .7 
33         
 16 2.3 23 2.4 18 1.3 27 2 32 8.6 25 3.5 23 1.2 
100         
 16 .9 21 2.3 14 .9 24 1.7 29 .9 25 3.5 24 3.8 
333         
 17 1.9 20 1.9 12 .9 28 3.2 27 2.4 18 1.9 22 2.7 
1000         
 19 0 16 .9 11 1.2 31 2.3 23 1.5 17 2.1 22 3.2 
3333         
 6 s 2.3 14 s 4.7 30 1.8 17 1.2 18 1.9 13 4.5
Positive Control 349 5.1 313 15.3 354 19.1 163 4.9 232 27.8 108 4.5 134 7.5

Abbreviations:
RLI = induced male Sprague Dawley rat liver S9
HLI = induced male Syrian hamster liver S9
s = Slight Toxicity; p = Precipitate; x = Slight Toxicity and Precipitate; t = Toxic;