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Study Information
Study Attribute Value
CEBS Accession Number: 002-02167-0004-0000-2
Chemical Name: Ethylenediamine
CASRN: 107-15-3
NTP Study Type: Genetic Toxicology - Bacterial Mutagenicity
NTP Study ID: 477362
Vehicle Control: Water
Study Result: Equivocal

Table Instructions and Notes:
You are currently viewing the results for this Salmonella study's detailed data.
Individual strain data is presented as mean ± standard error.
Abbreviations are noted at bottom of page.
Trial summary calls are shown in parentheses.
Standard NTP Protocol

Strain: TA100
Dose No Activation
(Equivocal)
No Activation
(Negative)
30% RLI
(Equivocal)
30% RLI
(Equivocal)
30% RLI
(Weakly Positive)
30% HLI
(Equivocal)
30% HLI
(Equivocal)
30% HLI
(Negative)
10% RLI
(Negative)
10% HLI
(Negative)
Protocol Preincubation Preincubation Preincubation Preincubation Preincubation Preincubation Preincubation Preincubation Preincubation Preincubation
ug/Plate Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM
 0         
140 9.4 92 13.4 152 2.4 140 10.8 107 3.5 112 6.3 121 5.4 135 8.6 93 5.3 80 3
100         
140 5.5 140 3 141 4.2
125         
136 5.2 109 4
250         
142 17.5 121 5.8
333         
141 5.5 80 6.2 131 9.5 112 1.2 111 5.5 136 6.6 101 5.5 87 7.4
500         
135 9.5 119 3.8
1000         
161 5.6 103 4.1 158 13.3 142 5 160 1.9 152 5 136 5.8 155 12.7 110 4.7 93 9.9
2500         
186 2.6 183 4.8
3333         
127 s 2 73 s 16.8 168 s 13.4 156 s 14.4 167 s 8.3 158 s 7 89 s 4.2 72 s 2.2
5000         
170 s 12.6 167 s 7
6666         
44 s 25.5 121 s 37.5 190 s 22 74 s 4.2 70 s 4.4
7500         
163 s 16.6 99 s 61.7
10000         
222 s 7.3 0 s 0 219 s 13.1 214 s 40.5 297 s 55.8 149 s 33.7 63 s 28.9 1 s .6 51 s 22.5 0 s 0
Positive Control 375 27.4 221 28.5 318 11.6 494 21.3 287 15.2 438 21.7 1438 33.9 490 7.9 946 45.8 409 17.8

Strain: TA1535
Dose No Activation
(Negative)
30% RLI
(Equivocal)
30% HLI
(Equivocal)
10% RLI
(Negative)
10% HLI
(Negative)
Protocol Preincubation Preincubation Preincubation Preincubation Preincubation
ug/Plate Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM
 0         
28 5.5 11 1.9 9 1.5 7 .3 7 1.3
333         
26 3.5 15 1.8 11 2 9 1.3 10 1.5
1000         
29 1.5 21 2.3 21 2.2 13 .3 12 3.8
3333         
5 s 1.2 6 s 2.7 18 s .6 7 s 2.7 6 s .7
6666         
4 s 1.5 2 s .9 3 s 3 1 s .7 2 s 1.7
10000         
2 s 1.9 0 s 0 27 s 5.7 4 s 2.6 1 s .7
Positive Control 90 5 43 22.6 87 3 97 8.7 29 2.8

Strain: TA98
Dose No Activation
(Negative)
30% RLI
(Negative)
30% HLI
(Negative)
Protocol Preincubation Preincubation Preincubation
ug/Plate Mean ±SEM Mean ±SEM Mean ±SEM
 0         
21 4.3 33 6.5 47 2.9
100         
24 6.5 39 13.7 28 1.3
333         
t 24 4.6 26 2
1000         
18 4.1 29 5.4 30 2.5
3333         
17 s 1.9 47 s 2.4 29 3
10000         
17 s 4.3 20 s 9.8 11 s 2.5
Positive Control 209 13 103 3.4 144 12.1

Abbreviations:
RLI = induced male Sprague Dawley rat liver S9
HLI = induced male Syrian hamster liver S9
s = Slight Toxicity; p = Precipitate; x = Slight Toxicity and Precipitate; t = Toxic;