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Study Information
Study Attribute Value
CEBS Accession Number: 002-02167-0005-0000-3
Chemical Name: Ethylenediamine
CASRN: 107-15-3
NTP Study Type: Genetic Toxicology - Bacterial Mutagenicity
NTP Study ID: 572096
Vehicle Control: Water
Study Result: Positive

Table Instructions and Notes:
You are currently viewing the results for this Salmonella study's detailed data.
Individual strain data is presented as mean ± standard error.
Abbreviations are noted at bottom of page.
Trial summary calls are shown in parentheses.
Standard NTP Protocol

Strain: TA100
Dose No Activation
(Equivocal)
No Activation
(Equivocal)
10% RLI
(Equivocal)
10% RLI
(Positive)
10% RLI
(Positive)
10% HLI
(Equivocal)
10% HLI
(Weakly Positive)
10% HLI
(Weakly Positive)
Protocol Preincubation Preincubation Preincubation Preincubation Preincubation Preincubation Preincubation Preincubation
ug/Plate Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM
 0         
127 8.9 123 1.5 177 1.9 151 18.3 128 3.2 149 8.1 124 15.3 137 5.8
100         
158 10.6 136 12.8 156 19.8 152 13.7 169 5 121 6.4
333         
151 9.8 145 18.5 160 11.3 172 2.6 166 6.3 159 9.7 154 17.3 123 9
1000         
165 6 134 5 221 7.8 211 8.5 212 6.7 169 15.9 185 14.3 171 13.7
1666         
159 11.1 218 6 231 4.5 192 4.2 171 2.6
3333         
202 10.8 185 8.1 212 2.5 267 12.5 238 .3 212 7.8 228 21.1 219 14.5
6666         
122 s 64.3 294 s 7.8 131 s 118 249 s 9.2 t
Positive Control 477 16 488 28.2 532 30.1 390 24.6 1343 24.1 748 29.1 395 2.9 1235 94.1

Strain: TA1535
Dose No Activation
(Positive)
No Activation
(Weakly Positive)
10% RLI
(Positive)
10% RLI
(Positive)
10% HLI
(Positive)
10% HLI
(Positive)
Protocol Preincubation Preincubation Preincubation Preincubation Preincubation Preincubation
ug/Plate Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM
 0         
28 3.9 28 1.2 10 1.7 13 1.2 12 1 11 1.5
100         
29 1 25 3.5 18 3.5 9 2.3 16 5.8 15 .7
333         
31 4.6 25 4 21 3.5 16 1.5 16 1.8 19 3.5
1000         
44 4 30 3.8 36 7 35 3.2 36 4.3 24 1.8
1666         
47 6.7 33 3.3 36 .3
3333         
67 5.1 54 10.2 83 10.6 71 4.4 82 3.3 81 2.6
6666         
78 s 1 147 s 16.8 75 s 32
Positive Control 487 15.9 592 4.6 199 10.3 148 5.8 176 7.3 228 11.5

Strain: TA97
Dose No Activation
(Negative)
10% RLI
(Negative)
10% HLI
(Equivocal)
Protocol Preincubation Preincubation Preincubation
ug/Plate Mean ±SEM Mean ±SEM Mean ±SEM
 0         
131 10.3 142 9.5 144 18.6
100         
127 27 127 28.2 165 3
333         
119 15.5 146 28.1 165 5.7
1000         
118 12.1 158 24.4 198 10.9
3333         
117 11.9 129 18.5 109 s 24.3
6666         
26 s 8.4 25 s 17.9 11 s 4.5
Positive Control 569 33.8 410 10.4 484 15.1

Strain: TA98
Dose No Activation
(Negative)
10% RLI
(Negative)
10% HLI
(Negative)
Protocol Preincubation Preincubation Preincubation
ug/Plate Mean ±SEM Mean ±SEM Mean ±SEM
 0         
23 2.5 32 3.8 33 5.9
100         
19 .6 37 2.6 42 .3
333         
24 3.2 38 2.4 33 5.3
1000         
24 2 41 1 29 8.1
3333         
25 4.4 25 2.6 21 9.2
6666         
5 s 4.7 10 s 3.2 17 s 4.4
Positive Control 824 40.3 462 28.8 576 48.2

Abbreviations:
RLI = induced male Sprague Dawley rat liver S9
HLI = induced male Syrian hamster liver S9
s = Slight Toxicity; p = Precipitate; x = Slight Toxicity and Precipitate; t = Toxic;