COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-02167-0006-0000-4
Chemical Name: Ethylenediamine
CASRN: 107-15-3
NTP Study Type: Genetic Toxicology - Bacterial Mutagenicity
NTP Study ID: 756389
Vehicle Control: Water
Study Result: Weakly Positive

Table Instructions and Notes:
You are currently viewing the results for this Salmonella study's detailed data.
Individual strain data is presented as mean ± standard error.
Abbreviations are noted at bottom of page.
Trial summary calls are shown in parentheses.
Standard NTP Protocol

Strain: TA100
Dose No Activation
(Equivocal) 		No Activation
(Equivocal) 		No Activation
(Equivocal) 		No Activation
(Positive) 		5% RLI
(Equivocal) 		5% HLI
(Equivocal) 		30% RLI
(Equivocal) 		30% RLI
(Positive) 		30% RLI
(Weakly Positive) 		30% HLI
(Equivocal) 		30% HLI
(Weakly Positive) 		30% HLI
(Weakly Positive) 		10% RLI
(Equivocal) 		10% HLI
(Equivocal)
Protocol Preincubation Preincubation Preincubation Preincubation Preincubation Preincubation Preincubation Preincubation Preincubation Preincubation Preincubation Preincubation Preincubation Preincubation
ug/Plate Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM 
 0         
 113 4.5 145 9.1 128 8.1 109 2.3 160 9 143 14.2 165 5 123 7.5 133 3.3 162 9.6 130 3.2 171 5.9 142 2.7 150 18.8 
100         
 136 7.1 135 15.7 99 4.2 
333         
 149 13.3 175 16.4 183 10.1 117 6 172 .9 136 7.7 179 9.2 151 4.4 145 1.3 181 7.7 156 10.1 175 6.1 167 4.3 179 15.9 
1000         
 155 3.5 180 3.7 187 11 154 6.7 174 3.3 173 8.4 185 12.5 154 2 174 15.7 186 24.1 166 9.8 182 3.2 139 7.5 170 7.8 
1666         
 148 11.3 165 7.4 174 4.6 195 6.4 195 12.7 173 3.7 200 7 202 19.3 193 4.7 209 12.7 208 16.5 
3333         
 190 5.5 197 7.5 49 s 37.2 232 4 228 24.7 189 6.9 172 3.3 210 5.2 219 10.4 215 5.5 172 5.9 200 3.2 226 12.7 211 6.4 
6666         
 28 s 10.7 76 s 16.9 214 1.9 181 s 22.3 291 5.4 251 21.1 203 5.2 53 s 39.9 198 10.7 267 62.7 159 s 66.9 183 s 14 
10000         
 294 s 16.5 187 s 27.5
Positive Control 483 14.7 446 8.7 393 20.9 563 26.1 936 84.2 1518 134.6 301 27.8 606 19.7 369 24.1 564 13.1 544 33.9 393 8.7 482 25.8 636 8.4

Strain: TA98
Dose No Activation
(Negative) 		30% RLI
(Negative) 		30% HLI
(Negative)
Protocol Preincubation Preincubation Preincubation
ug/Plate Mean ±SEM Mean ±SEM Mean ±SEM 
 0         
 21 4.8 36 4.2 35 2.7 
100         
 22 4.6 
333         
 15 1.9 28 .9 27 1.5 
1000         
 17 1.5 27 1.5 23 1 
3333         
 22 1.2 17 2.2 38 4.1 
6666         
 0 s 0 16 2.4 19 2.6 
10000         
 16 s 2.7 19 s 3.5
Positive Control 698 50.8 108 8.7 376 14.1

Abbreviations:
RLI = induced male Sprague Dawley rat liver S9
HLI = induced male Syrian hamster liver S9
s = Slight Toxicity; p = Precipitate; x = Slight Toxicity and Precipitate; t = Toxic;