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Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-02167-0007-0000-5 |
Chemical Name: | Ethylenediamine |
CASRN: | 107-15-3 |
NTP Study Type: | Genetic Toxicology - Bacterial Mutagenicity |
NTP Study ID: | 942194 |
Vehicle Control: | Water |
Study Result: | Positive |
Dose |
No Activation (Weakly Positive) |
No Activation (Weakly Positive) |
10% RLI (Equivocal) |
10% RLI (Weakly Positive) |
10% HLI (Positive) |
10% HLI (Weakly Positive) |
||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Protocol | Preincubation | Preincubation | Preincubation | Preincubation | Preincubation | Preincubation | ||||||
ug/Plate | Mean | ±SEM | Mean | ±SEM | Mean | ±SEM | Mean | ±SEM | Mean | ±SEM | Mean | ±SEM |
0 |
134 | 7.8 | 128 | 15.3 | 157 | .9 | 167 | 5.6 | 153 | 4.9 | 157 | 7.4 |
33 |
149 | 3.4 | 164 | 9 | 172 | 6.9 | ||||||
100 |
140 | 2.7 | 159 | 5.5 | 162 | 1.9 | 163 | 10.9 | 156 | 11.6 | 165 | 8.2 |
333 |
165 | 27.4 | 162 | 8.6 | 162 | 12.5 | 188 | 2.9 | 150 | 6.1 | 164 | 1.5 |
1000 |
165 | 16.2 | 161 | 5.2 | 164 | 5.2 | 205 | 3.5 | 173 | 1.5 | 183 | 4.2 |
3333 |
230 | 7.2 | 196 | 5 | 228 | 24.5 | 267 | 4.2 | 211 | 12.5 | 263 | 18.3 |
6666 |
10 s | 10 | 210 | 7.8 | 289 s | 10.9 | ||||||
Positive Control | 334 | 24.3 | 570 | 11 | 629 | 18.2 | 1378 | 65 | 1393 | 4.9 | 2347 | 23.2 |
Dose |
No Activation (Positive) |
No Activation (Positive) |
10% RLI (Positive) |
10% RLI (Positive) |
10% HLI (Positive) |
10% HLI (Positive) |
||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Protocol | Preincubation | Preincubation | Preincubation | Preincubation | Preincubation | Preincubation | ||||||
ug/Plate | Mean | ±SEM | Mean | ±SEM | Mean | ±SEM | Mean | ±SEM | Mean | ±SEM | Mean | ±SEM |
0 |
44 | 3.3 | 17 | 3 | 10 | 2.3 | 8 | 3.8 | 9 | 1.5 | 9 | .9 |
33 |
20 | 4.3 | 9 | 1 | 7 | .7 | ||||||
100 |
54 | 2.2 | 24 | 2 | 14 | 1.5 | 9 | 1.2 | 15 | 3.1 | 10 | 2.6 |
333 |
59 | 7.4 | 27 | 1.5 | 20 | 3.6 | 16 | 2.7 | 22 | 4.8 | 17 | 1.8 |
1000 |
76 | 2.5 | 38 | 3.2 | 37 | .9 | 24 | 3 | 41 | 2.6 | 21 | 1 |
3333 |
99 | 4.9 | 0 s | 0 | 102 s | 6.1 | 67 | 3 | 134 | 8.4 | 59 | 4.9 |
6666 |
0 s | 0 | 38 s | 10.8 | 185 s | 19.2 | ||||||
Positive Control | 347 | 8.3 | 490 | 17 | 167 | 2.9 | 330 | 19.7 | 339 | 23 | 573 | 18.7 |
Dose |
No Activation (Negative) |
10% RLI (Negative) |
10% HLI (Negative) |
|||
---|---|---|---|---|---|---|
Protocol | Preincubation | Preincubation | Preincubation | |||
ug/Plate | Mean | ±SEM | Mean | ±SEM | Mean | ±SEM |
0 |
129 | 1 | 191 | 9.6 | 212 | 20.6 |
100 |
158 | 6.7 | 209 | 1.7 | 234 | 7.5 |
333 |
139 | 11.4 | 223 | 9.3 | 211 | 15.3 |
1000 |
148 | 9 | 231 | 4.1 | 193 | .8 |
3333 |
124 | 8.7 | 166 | 8.4 | 185 | 14.7 |
6666 |
5 s | 1.9 | 82 s | 7.9 | 147 s | 4.5 |
Positive Control | 416 | 27.5 | 1124 | 38.4 | 1360 | 50.4 |
Dose |
No Activation (Negative) |
10% RLI (Negative) |
10% HLI (Negative) |
|||
---|---|---|---|---|---|---|
Protocol | Preincubation | Preincubation | Preincubation | |||
ug/Plate | Mean | ±SEM | Mean | ±SEM | Mean | ±SEM |
0 |
20 | 3.1 | 34 | 2.7 | 34 | 3 |
100 |
22 | 2.9 | 33 | 0 | 39 | 1.6 |
333 |
26 | 3.3 | 30 | 1.7 | 28 | 1.5 |
1000 |
22 | 2.8 | 31 | 1.8 | 34 | 3.1 |
3333 |
16 | 2.3 | 24 | 2.3 | 22 | 3.3 |
6666 |
9 | 9 | 3 s | 2.7 | 21 | 2.6 |
Positive Control | 605 | 35.2 | 642 | 25.7 | 1238 | 41.9 |