If this is the first time you are viewing this file, please choose 'Save As' from the 'File' menu and resave this file as an Excel file type. This will greatly speed up future viewings of this file.

Study Information
Study Attribute Value
CEBS Accession Number: 002-02167-0007-0000-5
Chemical Name: Ethylenediamine
CASRN: 107-15-3
NTP Study Type: Genetic Toxicology - Bacterial Mutagenicity
NTP Study ID: 942194
Vehicle Control: Water
Study Result: Positive

Table Instructions and Notes:
You are currently viewing the results for this Salmonella study's detailed data.
Individual strain data is presented as mean ± standard error.
Abbreviations are noted at bottom of page.
Trial summary calls are shown in parentheses.
Standard NTP Protocol

Strain: TA100
Dose No Activation
(Weakly Positive)
No Activation
(Weakly Positive)
10% RLI
(Equivocal)
10% RLI
(Weakly Positive)
10% HLI
(Positive)
10% HLI
(Weakly Positive)
Protocol Preincubation Preincubation Preincubation Preincubation Preincubation Preincubation
ug/Plate Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM
 0         
134 7.8 128 15.3 157 .9 167 5.6 153 4.9 157 7.4
33         
149 3.4 164 9 172 6.9
100         
140 2.7 159 5.5 162 1.9 163 10.9 156 11.6 165 8.2
333         
165 27.4 162 8.6 162 12.5 188 2.9 150 6.1 164 1.5
1000         
165 16.2 161 5.2 164 5.2 205 3.5 173 1.5 183 4.2
3333         
230 7.2 196 5 228 24.5 267 4.2 211 12.5 263 18.3
6666         
10 s 10 210 7.8 289 s 10.9
Positive Control 334 24.3 570 11 629 18.2 1378 65 1393 4.9 2347 23.2

Strain: TA1535
Dose No Activation
(Positive)
No Activation
(Positive)
10% RLI
(Positive)
10% RLI
(Positive)
10% HLI
(Positive)
10% HLI
(Positive)
Protocol Preincubation Preincubation Preincubation Preincubation Preincubation Preincubation
ug/Plate Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM Mean ±SEM
 0         
44 3.3 17 3 10 2.3 8 3.8 9 1.5 9 .9
33         
20 4.3 9 1 7 .7
100         
54 2.2 24 2 14 1.5 9 1.2 15 3.1 10 2.6
333         
59 7.4 27 1.5 20 3.6 16 2.7 22 4.8 17 1.8
1000         
76 2.5 38 3.2 37 .9 24 3 41 2.6 21 1
3333         
99 4.9 0 s 0 102 s 6.1 67 3 134 8.4 59 4.9
6666         
0 s 0 38 s 10.8 185 s 19.2
Positive Control 347 8.3 490 17 167 2.9 330 19.7 339 23 573 18.7

Strain: TA97
Dose No Activation
(Negative)
10% RLI
(Negative)
10% HLI
(Negative)
Protocol Preincubation Preincubation Preincubation
ug/Plate Mean ±SEM Mean ±SEM Mean ±SEM
 0         
129 1 191 9.6 212 20.6
100         
158 6.7 209 1.7 234 7.5
333         
139 11.4 223 9.3 211 15.3
1000         
148 9 231 4.1 193 .8
3333         
124 8.7 166 8.4 185 14.7
6666         
5 s 1.9 82 s 7.9 147 s 4.5
Positive Control 416 27.5 1124 38.4 1360 50.4

Strain: TA98
Dose No Activation
(Negative)
10% RLI
(Negative)
10% HLI
(Negative)
Protocol Preincubation Preincubation Preincubation
ug/Plate Mean ±SEM Mean ±SEM Mean ±SEM
 0         
20 3.1 34 2.7 34 3
100         
22 2.9 33 0 39 1.6
333         
26 3.3 30 1.7 28 1.5
1000         
22 2.8 31 1.8 34 3.1
3333         
16 2.3 24 2.3 22 3.3
6666         
9 9 3 s 2.7 21 2.6
Positive Control 605 35.2 642 25.7 1238 41.9

Abbreviations:
RLI = induced male Sprague Dawley rat liver S9
HLI = induced male Syrian hamster liver S9
s = Slight Toxicity; p = Precipitate; x = Slight Toxicity and Precipitate; t = Toxic;