Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01006-0034-0000-6 |
Chemical Name: | Wyeth 14,643 (WY) |
CASRN: | 50892-23-4 |
NTP Study Type: | Genetic Toxicology - Micronucleus |
NTP Study ID: | G91069 |
Strain and Species: | Harlan Sprague Dawley Rat |
Study Result: | Male: Negative; Female: Negative |
Blood
Start Date | Sample Collection Time | Sex | Cell | Methodology Used | Dosing Regimen | Route | Trend Test P-Value |
---|---|---|---|---|---|---|---|
2012-02-24 | 24 hour | Male | PCE | Flow Cytometry | Gavage x 28, 28 day | Gavage | 0.096 |
Dose (mg/kg) | Number of Animals Scored | Mean MN-PCE/1000 PCE ± SEM | Pairwise P | ||||
---|---|---|---|---|---|---|---|
Vehicle Control | Deionized Water with 2% Tween 80 | 0 |
5 | 0.510 ± 0.090 | |||
Test Chemical | Wyeth 14,643 (WY) | 6.25 |
5 | 0.800 ± 0.063 | 0.055 | ||
12.5 |
5 | 0.860 ± 0.202 | 0.050 | ||||
25 |
5 | 0.790 ± 0.075 | 0.053 |
Start Date | Sample Collection Time | Sex | Cell | Methodology Used | Dosing Regimen | Route | Trend Test P-Value |
---|---|---|---|---|---|---|---|
2012-02-24 | 24 hour | Male | PCE | Flow Cytometry | Gavage x 28, 28 day | Gavage | 0.110 |
Dose (mg/kg) | Number of Animals Scored | Mean Percent PCE ± SEM | Pairwise P | ||||
---|---|---|---|---|---|---|---|
Vehicle Control | Deionized Water with 2% Tween 80 | 0 |
5 | 0.974 ± 0.053 | |||
Test Chemical | Wyeth 14,643 (WY) | 6.25 |
5 | 0.759 ± 0.022 | 1.000 | ||
12.5 |
5 | 1.175 ± 0.146 | 0.236 | ||||
25 |
5 | 1.083 ± 0.068 | 0.249 |
Start Date | Sample Collection Time | Sex | Cell | Methodology Used | Dosing Regimen | Route | Trend Test P-Value |
---|---|---|---|---|---|---|---|
2012-02-24 | 24 hour | Male | NCE | Flow Cytometry | Gavage x 28, 28 day | Gavage | 0.126 |
Dose (mg/kg) | Number of Animals Scored | Mean MN-NCE/1000 NCE ± SEM | Pairwise P | ||||
---|---|---|---|---|---|---|---|
Vehicle Control | Deionized Water with 2% Tween 80 | 0 |
5 | 0.079 ± 0.013 | |||
Test Chemical | Wyeth 14,643 (WY) | 6.25 |
5 | 0.161 ± 0.035 | 0.131 | ||
12.5 |
5 | 0.291 ± 0.129 | 0.032 | ||||
25 |
5 | 0.120 ± 0.026 | 0.465 |
Blood
Start Date | Sample Collection Time | Sex | Cell | Methodology Used | Dosing Regimen | Route | Trend Test P-Value |
---|---|---|---|---|---|---|---|
2012-02-25 | 24 hour | Female | PCE | Flow Cytometry | Gavage x 28, 28 day | Gavage | 0.292 |
Dose (mg/kg) | Number of Animals Scored | Mean MN-PCE/1000 PCE ± SEM | Pairwise P | ||||
---|---|---|---|---|---|---|---|
Vehicle Control | Deionized Water with 2% Tween 80 | 0 |
5 | 0.470 ± 0.090 | |||
Test Chemical | Wyeth 14,643 (WY) | 6.25 |
5 | 0.730 ± 0.132 | 0.105 | ||
12.5 |
5 | 0.577 ± 0.073 | 0.127 | ||||
25 |
5 | 0.616 ± 0.059 | 0.135 |
Start Date | Sample Collection Time | Sex | Cell | Methodology Used | Dosing Regimen | Route | Trend Test P-Value |
---|---|---|---|---|---|---|---|
2012-02-25 | 24 hour | Female | PCE | Flow Cytometry | Gavage x 28, 28 day | Gavage | 0.013 |
Dose (mg/kg) | Number of Animals Scored | Mean Percent PCE ± SEM | Pairwise P | ||||
---|---|---|---|---|---|---|---|
Vehicle Control | Deionized Water with 2% Tween 80 | 0 |
5 | 1.104 ± 0.089 | |||
Test Chemical | Wyeth 14,643 (WY) | 6.25 |
5 | 0.950 ± 0.086 | 1.000 | ||
12.5 |
5 | 1.289 ± 0.072 | 0.187 | ||||
25 |
5 | 1.401 ± 0.112 | 0.052 |
Start Date | Sample Collection Time | Sex | Cell | Methodology Used | Dosing Regimen | Route | Trend Test P-Value |
---|---|---|---|---|---|---|---|
2012-02-25 | 24 hour | Female | NCE | Flow Cytometry | Gavage x 28, 28 day | Gavage | 0.446 |
Dose (mg/kg) | Number of Animals Scored | Mean MN-NCE/1000 NCE ± SEM | Pairwise P | ||||
---|---|---|---|---|---|---|---|
Vehicle Control | Deionized Water with 2% Tween 80 | 0 |
5 | 0.036 ± 0.004 | |||
Test Chemical | Wyeth 14,643 (WY) | 6.25 |
5 | 0.057 ± 0.006 | 0.056 | ||
12.5 |
5 | 0.044 ± 0.010 | 0.889 | ||||
25 |
5 | 0.040 ± 0.005 | 0.946 |