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Study Information
Study Attribute Value
CEBS Accession Number: 002-01134-0002-0000-3
Chemical Name: Perfluorobutane sulfonate (PFBS)
CASRN: 375-73-5
NTP Study Type: Genetic Toxicology - Micronucleus
NTP Study ID: G04006
Strain and Species: Harlan Sprague Dawley Rat
Study Result: Male: Negative; Female: Negative

Blood

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
2012-02-17 24 hour Male PCE Flow Cytometry Gavage x 56, 28 day Gavage 0.469
  Dose (mg/kg) Number of Animals Scored Mean MN-PCE/1000 PCE ± SEM Pairwise P
Vehicle Control Deionized Water with 2% Tween 80 
 0         
 5 0.590 ± 0.114
Test Chemical Perfluorobutane sulfonate (PFBS) 
31.3       
 5 0.500 ± 0.112 0.617 
62.5       
 5 0.620 ± 0.046 0.574 
125         
 5 0.590 ± 0.121 0.608 
250         
 5 0.570 ± 0.115 0.626

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
2012-02-17 24 hour Male PCE Flow Cytometry Gavage x 56, 28 day Gavage 0.000
  Dose (mg/kg) Number of Animals Scored Mean Percent PCE ± SEM Pairwise P
Vehicle Control Deionized Water with 2% Tween 80 
 0         
 5 1.012 ± 0.063
Test Chemical Perfluorobutane sulfonate (PFBS) 
31.3       
 5 0.930 ± 0.063 1.000 
62.5       
 5 0.909 ± 0.060 1.000 
125         
 5 0.830 ± 0.078 0.375 
250         
 5 0.553 ± 0.098 0.004

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
2012-02-17 24 hour Male NCE Flow Cytometry Gavage x 56, 28 day Gavage 0.984
  Dose (mg/kg) Number of Animals Scored Mean MN-NCE/1000 NCE ± SEM Pairwise P
Vehicle Control Deionized Water with 2% Tween 80 
 0         
 5 0.333 ± 0.110
Test Chemical Perfluorobutane sulfonate (PFBS) 
31.3       
 5 0.120 ± 0.011 1.000 
62.5       
 5 0.131 ± 0.028 1.000 
125         
 5 0.126 ± 0.019 1.000 
250         
 5 0.115 ± 0.021 1.000

Blood

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
2012-02-18 24 hour Female PCE Flow Cytometry Gavage x 56, 28 day Gavage 0.154
  Dose (mg/kg) Number of Animals Scored Mean MN-PCE/1000 PCE ± SEM Pairwise P
Vehicle Control Deionized Water with 2% Tween 80 
 0         
 5 0.620 ± 0.118
Test Chemical Perfluorobutane sulfonate (PFBS) 
31.3       
 5 0.510 ± 0.091 0.630 
62.5       
 5 0.630 ± 0.178 0.558 
125         
 5 0.740 ± 0.073 0.349 
250         
 5 0.700 ± 0.082 0.362

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
2012-02-18 24 hour Female PCE Flow Cytometry Gavage x 56, 28 day Gavage 0.001
  Dose (mg/kg) Number of Animals Scored Mean Percent PCE ± SEM Pairwise P
Vehicle Control Deionized Water with 2% Tween 80 
 0         
 5 1.225 ± 0.161
Test Chemical Perfluorobutane sulfonate (PFBS) 
31.3       
 5 0.781 ± 0.100 0.046 
62.5       
 5 0.799 ± 0.042 0.053 
125         
 5 0.701 ± 0.128 0.009 
250         
 5 0.553 ± 0.098 0.001

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
2012-02-18 24 hour Female NCE Flow Cytometry Gavage x 56, 28 day Gavage 0.647
  Dose (mg/kg) Number of Animals Scored Mean MN-NCE/1000 NCE ± SEM Pairwise P
Vehicle Control Deionized Water with 2% Tween 80 
 0         
 5 0.059 ± 0.012
Test Chemical Perfluorobutane sulfonate (PFBS) 
31.3       
 5 0.086 ± 0.016 0.159 
62.5       
 5 0.080 ± 0.017 0.192 
125         
 5 0.087 ± 0.012 0.206 
250         
 5 0.061 ± 0.011 0.213