COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-01294-0024-0000-4
Chemical Name: 2-Biphenylamine hydrochloride
CASRN: 2185-92-4
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 047126_CA
Study Result: Negative

View Detailed Data
Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 12/13/84 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.3257
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
200         
 8 2.00 ± 1.00 0.0281
Test Chemical 2-Biphenylamine hydrochloride 
125         
 8 0.50 ± 0.50 0.5000
  
250         
 8 1.00 ± 0.38 0.2062
  
500         
 6 0.67 ± 0.67 0.3861
Vehicle Control No Stressor 
 0         
 8 0.50 ± 0.33 0.0000


View Detailed Data
Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 05/10/88 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.0148
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
50         
 8 20.50 ± 3.38 0.0000
Test Chemical 2-Biphenylamine hydrochloride 
62.5       
 8 0.75 ± 0.53 0.7116
  
125         
 8 1.75 ± 0.80 0.2451
  
250         
 8 2.75 ± 0.65 0.0584
Vehicle Control No Stressor 
 0         
 7 1.14 ± 0.59 0.0000


View Detailed Data
Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 08/29/88 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.1763
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
50         
 8 19.00 ± 1.73 0.0000
Test Chemical 2-Biphenylamine hydrochloride 
187.5       
 8 1.00 ± 0.53 0.3521
  
250         
 8 1.50 ± 0.50 0.1573
Vehicle Control No Stressor 
 0         
 8 0.75 ± 0.75 0.0000


Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed