| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-01364-0007-0000-3 |
| Chemical Name: | 2-Naphthylamine |
| CASRN: | 91-59-8 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 080086_SCE |
| Study Result: | Positive |
Table Instructions and Notes:
Below is a summary of Sister Chromatid Exchange data. Use the link below the summary tables to view detailed data for that specific trial.
| Test Type | Start Date | Sample Time (h) | Species | Sex | Strain | Tissue | Protocol | Trend Test P |
|---|---|---|---|---|---|---|---|---|
| SCE | 03/21/85 | 23 | Mouse | Male | B6C3F1 | Bone Marrow | IP/IJ x 1, 23 hour |
| Dose (mg/kg) |
n | SCE / Cell (Mean ± SEM) |
Pairwise P | ||
|---|---|---|---|---|---|
| Vehicle Control | Dimethyl Sulfoxide | 0 |
4 | 5.00 ± 0.432 | |
| Test Chemical | 2-Naphthylamine | 87.5 |
4 | 6.76 ± 0.617 | |
175 |
4 | 7.00 ± 0.233 | |||
350 |
4 | 10.97 ± 1.146 | |||
| Positive Control | Dimethylbenzanthracene | 2.5 |
4 | 13.66 ± 1.732 | |
| Test Type | Start Date | Sample Time (h) | Species | Sex | Strain | Tissue | Protocol | Trend Test P |
|---|---|---|---|---|---|---|---|---|
| SCE | 12/02/87 | 42 | Mouse | Male | B6C3F1 | Bone Marrow | IP/IJ x 1, 42 hour |
| Dose (mg/kg) |
n | SCE / Cell (Mean ± SEM) |
Pairwise P | ||
|---|---|---|---|---|---|
| Vehicle Control | Dimethyl Sulfoxide | 0 |
4 | 5.67 ± 0.264 | |
| Test Chemical | 2-Naphthylamine | 87.5 |
4 | 5.49 ± 0.573 | |
175 |
4 | 7.34 ± 1.072 | |||
350 |
7 | 8.27 ± 0.762 | |||
| Positive Control | Dimethylbenzanthracene | 2.5 |
4 | 12.70 ± 1.181 | |
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed