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Study Information
Study Attribute Value
CEBS Accession Number: 002-01525-0003-0000-8
Chemical Name: 5,5-Diphenylhydantoin (phenytoin)
CASRN: 57-41-0
NTP Study Type: Genetic Toxicology - Micronucleus
NTP Study ID: 110489
Strain and Species: BALB/C Mouse
Study Result: Male: Negative

Bone Marrow

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
1990-09-04 24 hour Male PCE Slide Scoring Intraperitoneal Injection x 1, 24 hour Intraperitoneal Injection 0.211
  Dose (mg/kg) Number of Animals Scored Mean MN-PCE/1000 PCE ± SEM Pairwise P
Vehicle Control Naoh 
 0         
 5 3.100 ± 0.290
Test Chemical 5,5-Diphenylhydantoin (phenytoin) 
 0.1       
 5 2.600 ± 1.130 0.678 
 0.5       
 5 3.200 ± 0.580 0.465 
1         
 5 4.100 ± 0.930 0.205 
5         
 5 3.000 ± 0.890 0.536 
10         
 5 3.300 ± 0.820 0.431 
20         
 5 4.000 ± 0.720 0.228
Positive Control Mitomycin-C 
 0.5       
 5 3.900 ± 0.530 0.169 
5         
 5 9.600 ± 1.860 Value less than 0.0001

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
1990-09-04 24 hour Male PCE Slide Scoring Intraperitoneal Injection x 1, 24 hour Intraperitoneal Injection
  Dose (mg/kg) Number of Animals Scored Mean Percent PCE ± SEM Pairwise P
Vehicle Control Naoh 
 0         
 5 54.400 ± 2.460
Test Chemical 5,5-Diphenylhydantoin (phenytoin) 
 0.1       
 5 52.300 ± 2.580 
 0.5       
 5 49.000 ± 4.620 
1         
 5 44.800 ± 3.410 
5         
 5 44.900 ± 8.490 
10         
 5 48.400 ± 4.370 
20         
 5 43.800 ± 4.120
Positive Control Mitomycin-C 
 0.5       
 5 56.300 ± 5.080 
5         
 5 49.900 ± 3.350