COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-01740-0004-0000-8
Chemical Name: Bromochloroacetic acid
CASRN: 5589-96-8
NTP Study Type: Genetic Toxicology - Micronucleus
NTP Study ID: A22969
Strain and Species: B6C3F1 Mouse
Study Result: Male: Negative; Female: Negative

Blood

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
2001-05-25 24 hour Male PCE Slide Scoring Dosed-Water x 91, 13 week Dosed-Water 0.102
  Dose (other) Number of Animals Scored Mean MN-PCE/1000 PCE ± SEM Pairwise P
Vehicle Control Solvent 
 0         
 10 3.900 ± 0.460
Test Chemical Bromochloroacetic acid 
62.5       
 0.000 ± 0.000 
125         
 0.000 ± 0.000 
250         
 0.000 ± 0.000 
500         
 0.000 ± 0.000 
1000         
 10 5.100 ± 0.860 0.102

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
2001-05-25 24 hour Male PCE Slide Scoring Dosed-Water x 91, 13 week Dosed-Water
  Dose (other) Number of Animals Scored Mean Percent PCE ± SEM Pairwise P
Vehicle Control Solvent 
 0         
 10 4.370 ± 0.250
Test Chemical Bromochloroacetic acid 
62.5       
 0.000 ± 0.000 
125         
 0.000 ± 0.000 
250         
 0.000 ± 0.000 
500         
 0.000 ± 0.000 
1000         
 10 4.560 ± 0.220

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
2001-05-25 24 hour Male NCE Slide Scoring Dosed-Water x 91, 13 week Dosed-Water 0.603
  Dose (other) Number of Animals Scored Mean MN-NCE/1000 NCE ± SEM Pairwise P
Vehicle Control Solvent 
 0         
 10 4.800 ± 0.570
Test Chemical Bromochloroacetic acid 
62.5       
 10 5.100 ± 0.590 0.381 
125         
 10 3.900 ± 0.670 0.833 
250         
 10 5.300 ± 0.560 0.309 
500         
 8 4.750 ± 0.590 0.519 
1000         
 10 4.500 ± 0.580 0.622

Blood

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
2001-05-26 24 hour Female PCE Slide Scoring Dosed-Water x 91, 13 week Dosed-Water 0.257
  Dose (other) Number of Animals Scored Mean MN-PCE/1000 PCE ± SEM Pairwise P
Vehicle Control Solvent 
 0         
 10 2.400 ± 0.810
Test Chemical Bromochloroacetic acid 
62.5       
 0.000 ± 0.000 
125         
 0.000 ± 0.000 
250         
 0.000 ± 0.000 
500         
 0.000 ± 0.000 
1000         
 10 3.100 ± 0.670 0.257

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
2001-05-26 24 hour Female PCE Slide Scoring Dosed-Water x 91, 13 week Dosed-Water
  Dose (other) Number of Animals Scored Mean Percent PCE ± SEM Pairwise P
Vehicle Control Solvent 
 0         
 10 3.990 ± 0.290
Test Chemical Bromochloroacetic acid 
62.5       
 0.000 ± 0.000 
125         
 0.000 ± 0.000 
250         
 0.000 ± 0.000 
500         
 0.000 ± 0.000 
1000         
 10 4.450 ± 0.170

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
2001-05-26 24 hour Female NCE Slide Scoring Dosed-Water x 91, 13 week Dosed-Water 0.467
  Dose (other) Number of Animals Scored Mean MN-NCE/1000 NCE ± SEM Pairwise P
Vehicle Control Solvent 
 0         
 10 2.600 ± 0.430
Test Chemical Bromochloroacetic acid 
62.5       
 10 3.300 ± 0.450 0.181 
125         
 10 4.200 ± 0.530 0.026 
250         
 10 4.600 ± 0.540 0.009 
500         
 10 3.800 ± 0.680 0.067 
1000         
 10 3.300 ± 0.470 0.181