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Study Information
Study Attribute Value
CEBS Accession Number: 002-01742-0003-0000-9
Chemical Name: Bromodichloroacetic Acid
CASRN: 71133-14-7
NTP Study Type: Genetic Toxicology - Micronucleus
NTP Study ID: A97618
Strain and Species: B6C3F1 Mouse
Study Result: Male: Negative; Female: Negative

Blood

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
2001-06-21 24 hour Male PCE Slide Scoring Dosed-Water x 91, 13 week Dosed-Water 0.500
  Dose (other) Number of Animals Scored Mean MN-PCE/1000 PCE ± SEM Pairwise P
Vehicle Control Solvent 
 0         
 10 3.800 ± 0.530
Test Chemical Bromodichloroacetic Acid 
62.5       
 0.000 ± 0.000 
125         
 0.000 ± 0.000 
250         
 0.000 ± 0.000 
500         
 0.000 ± 0.000 
1000         
 10 3.800 ± 0.360 0.500

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
2001-06-21 24 hour Male PCE Slide Scoring Dosed-Water x 91, 13 week Dosed-Water
  Dose (other) Number of Animals Scored Mean Percent PCE ± SEM Pairwise P
Vehicle Control Solvent 
 0         
 10 3.910 ± 0.250
Test Chemical Bromodichloroacetic Acid 
62.5       
 0.000 ± 0.000 
125         
 0.000 ± 0.000 
250         
 0.000 ± 0.000 
500         
 0.000 ± 0.000 
1000         
 10 4.640 ± 0.210

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
2001-06-21 24 hour Male NCE Slide Scoring Dosed-Water x 91, 13 week Dosed-Water 0.045
  Dose (other) Number of Animals Scored Mean MN-NCE/1000 NCE ± SEM Pairwise P
Vehicle Control Solvent 
 0         
 10 3.500 ± 0.560
Test Chemical Bromodichloroacetic Acid 
62.5       
 9 3.110 ± 0.450 0.679 
125         
 10 3.400 ± 0.690 0.548 
250         
 10 3.300 ± 0.370 0.596 
500         
 10 4.200 ± 0.490 0.212 
1000         
 10 4.400 ± 0.520 0.155

Blood

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
2001-06-22 24 hour Female PCE Slide Scoring Dosed-Water x 91, 13 week Dosed-Water 0.166
  Dose (other) Number of Animals Scored Mean MN-PCE/1000 PCE ± SEM Pairwise P
Vehicle Control Solvent 
 0         
 10 3.000 ± 0.610
Test Chemical Bromodichloroacetic Acid 
62.5       
 0.000 ± 0.000 
125         
 0.000 ± 0.000 
250         
 0.000 ± 0.000 
500         
 0.000 ± 0.000 
1000         
 10 3.800 ± 0.290 0.166

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
2001-06-22 24 hour Female PCE Slide Scoring Dosed-Water x 91, 13 week Dosed-Water
  Dose (other) Number of Animals Scored Mean Percent PCE ± SEM Pairwise P
Vehicle Control Solvent 
 0         
 10 4.520 ± 0.350
Test Chemical Bromodichloroacetic Acid 
62.5       
 0.000 ± 0.000 
125         
 0.000 ± 0.000 
250         
 0.000 ± 0.000 
500         
 0.000 ± 0.000 
1000         
 10 5.700 ± 0.370

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
2001-06-22 24 hour Female NCE Slide Scoring Dosed-Water x 91, 13 week Dosed-Water 0.215
  Dose (other) Number of Animals Scored Mean MN-NCE/1000 NCE ± SEM Pairwise P
Vehicle Control Solvent 
 0         
 10 4.200 ± 0.510
Test Chemical Bromodichloroacetic Acid 
62.5       
 10 2.400 ± 0.270 0.987 
125         
 10 2.400 ± 0.450 0.987 
250         
 10 2.500 ± 0.400 0.981 
500         
 10 3.200 ± 0.390 0.878 
1000         
 10 3.600 ± 0.430 0.752