Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01747-0001-0000-2 |
Chemical Name: | Bupivacaine hydrochloride |
CASRN: | 14252-80-3 |
NTP Study Type: | Genetic Toxicology - Micronucleus |
NTP Study ID: | A99006 |
Strain and Species: | B6C3F1 Mouse |
Study Result: | Male: Negative |
Bone Marrow
Start Date | Sample Collection Time | Sex | Cell | Methodology Used | Dosing Regimen | Route | Trend Test P-Value |
---|---|---|---|---|---|---|---|
2002-07-30 | 24 hour | Male | PCE | Slide Scoring | Gavage x 3, 24 hour | Gavage | 0.861 |
Dose (mg/kg) | Number of Animals Scored | Mean MN-PCE/1000 PCE ± SEM | Pairwise P | ||||
---|---|---|---|---|---|---|---|
Vehicle Control | Water | 0 |
5 | 1.000 ± 0.160 | |||
Test Chemical | Bupivacaine hydrochloride | 25 |
5 | 0.800 ± 0.340 | 0.681 | ||
50 |
5 | 0.900 ± 0.330 | 0.591 | ||||
100 |
4 | 0.500 ± 0.200 | 0.884 | ||||
Positive Control | Cyclophosphamide | 20 |
5 | 21.200 ± 1.080 | Value less than 0.0001 |
Start Date | Sample Collection Time | Sex | Cell | Methodology Used | Dosing Regimen | Route | Trend Test P-Value |
---|---|---|---|---|---|---|---|
2002-07-30 | 24 hour | Male | PCE | Slide Scoring | Gavage x 3, 24 hour | Gavage |
Dose (mg/kg) | Number of Animals Scored | Mean Percent PCE ± SEM | Pairwise P | ||||
---|---|---|---|---|---|---|---|
Vehicle Control | Water | 0 |
5 | 51.300 ± 2.830 | |||
Test Chemical | Bupivacaine hydrochloride | 25 |
5 | 55.400 ± 2.610 | |||
50 |
5 | 52.700 ± 3.960 | |||||
100 |
4 | 49.380 ± 2.510 | |||||
Positive Control | Cyclophosphamide | 20 |
5 | 50.400 ± 2.900 |
Bone Marrow
Start Date | Sample Collection Time | Sex | Cell | Methodology Used | Dosing Regimen | Route | Trend Test P-Value |
---|---|---|---|---|---|---|---|
2002-08-13 | 24 hour | Male | PCE | Slide Scoring | Gavage x 3, 24 hour | Gavage | 0.679 |
Dose (mg/kg) | Number of Animals Scored | Mean MN-PCE/1000 PCE ± SEM | Pairwise P | ||||
---|---|---|---|---|---|---|---|
Vehicle Control | Water | 0 |
5 | 0.900 ± 0.290 | |||
Test Chemical | Bupivacaine hydrochloride | 25 |
5 | 1.300 ± 0.200 | 0.197 | ||
50 |
5 | 1.800 ± 0.460 | 0.042 | ||||
100 |
4 | 0.630 ± 0.310 | 0.745 | ||||
Positive Control | Cyclophosphamide | 20 |
5 | 28.100 ± 2.450 | Value less than 0.0001 |
Start Date | Sample Collection Time | Sex | Cell | Methodology Used | Dosing Regimen | Route | Trend Test P-Value |
---|---|---|---|---|---|---|---|
2002-08-13 | 24 hour | Male | PCE | Slide Scoring | Gavage x 3, 24 hour | Gavage |
Dose (mg/kg) | Number of Animals Scored | Mean Percent PCE ± SEM | Pairwise P | ||||
---|---|---|---|---|---|---|---|
Vehicle Control | Water | 0 |
5 | 54.600 ± 0.750 | |||
Test Chemical | Bupivacaine hydrochloride | 25 |
5 | 54.900 ± 1.600 | |||
50 |
5 | 51.100 ± 2.550 | |||||
100 |
4 | 43.630 ± 1.980 | |||||
Positive Control | Cyclophosphamide | 20 |
5 | 46.400 ± 0.660 |