Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01931-0011-0000-8 |
Chemical Name: | Cyclophosphamide monohydrate |
CASRN: | 6055-19-2 |
NTP Study Type: | Genetic Toxicology - Micronucleus |
NTP Study ID: | 813361 |
Strain and Species: | Fischer 344 Rat |
Study Result: | Male: Positive |
Bone Marrow
Start Date | Sample Collection Time | Sex | Cell | Methodology Used | Dosing Regimen | Route | Trend Test P-Value |
---|---|---|---|---|---|---|---|
1991-05-06 | 24 hour | Male | PCE | Slide Scoring | Intraperitoneal Injection x 1, 24 hour | Intraperitoneal Injection | 0.000 |
Dose (mg/kg) | Number of Animals Scored | Mean MN-PCE/1000 PCE ± SEM | Pairwise P | ||||
---|---|---|---|---|---|---|---|
Vehicle Control | Phosphate Buffered Saline | 0 |
5 | 2.700 ± 0.370 | |||
0 |
5 | 2.700 ± 0.370 | |||||
Test Chemical | Cyclophosphamide monohydrate | 9.375 |
5 | 11.500 ± 1.300 | Value less than 0.0001 | ||
9.375 |
5 | 11.500 ± 1.300 | Value less than 0.0001 | ||||
18.75 |
5 | 18.200 ± 1.870 | Value less than 0.0001 | ||||
18.75 |
5 | 18.200 ± 1.870 | Value less than 0.0001 | ||||
37.5 |
5 | 18.200 ± 2.630 | Value less than 0.0001 | ||||
37.5 |
5 | 18.200 ± 2.630 | Value less than 0.0001 | ||||
75 |
5 | 23.000 ± 2.220 | Value less than 0.0001 | ||||
75 |
5 | 23.000 ± 2.220 | Value less than 0.0001 |
Start Date | Sample Collection Time | Sex | Cell | Methodology Used | Dosing Regimen | Route | Trend Test P-Value |
---|---|---|---|---|---|---|---|
1991-05-06 | 24 hour | Male | PCE | Slide Scoring | Intraperitoneal Injection x 1, 24 hour | Intraperitoneal Injection |
Dose (mg/kg) | Number of Animals Scored | Mean Percent PCE ± SEM | Pairwise P | ||||
---|---|---|---|---|---|---|---|
Vehicle Control | Phosphate Buffered Saline | 0 |
5 | 43.700 ± 3.940 | |||
0 |
5 | 43.700 ± 3.940 | |||||
Test Chemical | Cyclophosphamide monohydrate | 9.375 |
5 | 35.200 ± 8.160 | |||
9.375 |
5 | 35.200 ± 8.160 | |||||
18.75 |
5 | 43.200 ± 5.130 | |||||
18.75 |
5 | 43.200 ± 5.130 | |||||
37.5 |
5 | 33.200 ± 5.080 | |||||
37.5 |
5 | 33.200 ± 5.080 | |||||
75 |
5 | 28.600 ± 2.500 | |||||
75 |
5 | 28.600 ± 2.500 |
Bone Marrow
Start Date | Sample Collection Time | Sex | Cell | Methodology Used | Dosing Regimen | Route | Trend Test P-Value |
---|---|---|---|---|---|---|---|
1991-05-06 | 24 hour | Male | PCE | Slide Scoring | Intraperitoneal Injection x 1, 24 hour | Intraperitoneal Injection | 0.000 |
Dose (mg/kg) | Number of Animals Scored | Mean MN-PCE/1000 PCE ± SEM | Pairwise P | ||||
---|---|---|---|---|---|---|---|
Vehicle Control | Phosphate Buffered Saline | 0 |
5 | 2.300 ± 0.460 | |||
0 |
5 | 2.300 ± 0.460 | |||||
Test Chemical | Cyclophosphamide monohydrate | 1.875 |
5 | 4.000 ± 0.160 | 0.016 | ||
1.875 |
5 | 4.000 ± 0.160 | 0.016 | ||||
3.75 |
5 | 8.800 ± 1.630 | Value less than 0.0001 | ||||
3.75 |
5 | 8.800 ± 1.630 | Value less than 0.0001 | ||||
7.5 |
5 | 7.100 ± 1.200 | Value less than 0.0001 | ||||
7.5 |
5 | 7.100 ± 1.200 | Value less than 0.0001 | ||||
15 |
5 | 18.200 ± 1.240 | Value less than 0.0001 | ||||
15 |
5 | 18.200 ± 1.240 | Value less than 0.0001 |
Start Date | Sample Collection Time | Sex | Cell | Methodology Used | Dosing Regimen | Route | Trend Test P-Value |
---|---|---|---|---|---|---|---|
1991-05-06 | 24 hour | Male | PCE | Slide Scoring | Intraperitoneal Injection x 1, 24 hour | Intraperitoneal Injection |
Dose (mg/kg) | Number of Animals Scored | Mean Percent PCE ± SEM | Pairwise P | ||||
---|---|---|---|---|---|---|---|
Vehicle Control | Phosphate Buffered Saline | 0 |
5 | 31.000 ± 3.710 | |||
0 |
5 | 31.000 ± 3.710 | |||||
Test Chemical | Cyclophosphamide monohydrate | 1.875 |
5 | 26.100 ± 3.620 | |||
1.875 |
5 | 26.100 ± 3.620 | |||||
3.75 |
5 | 35.300 ± 1.640 | |||||
3.75 |
5 | 35.300 ± 1.640 | |||||
7.5 |
5 | 33.000 ± 3.980 | |||||
7.5 |
5 | 33.000 ± 3.980 | |||||
15 |
5 | 27.700 ± 1.250 | |||||
15 |
5 | 27.700 ± 1.250 |
Bone Marrow
Start Date | Sample Collection Time | Sex | Cell | Methodology Used | Dosing Regimen | Route | Trend Test P-Value |
---|---|---|---|---|---|---|---|
1991-05-06 | 48 hour | Male | PCE | Slide Scoring | Intraperitoneal Injection x 1, 48 hour | Intraperitoneal Injection | 0.000 |
Dose (mg/kg) | Number of Animals Scored | Mean MN-PCE/1000 PCE ± SEM | Pairwise P | ||||
---|---|---|---|---|---|---|---|
Vehicle Control | Phosphate Buffered Saline | 0 |
5 | 1.800 ± 0.120 | |||
0 |
5 | 1.800 ± 0.120 | |||||
Test Chemical | Cyclophosphamide monohydrate | 9.375 |
5 | 5.200 ± 0.750 | Value less than 0.0001 | ||
9.375 |
5 | 5.200 ± 0.750 | Value less than 0.0001 | ||||
18.75 |
5 | 15.400 ± 1.650 | Value less than 0.0001 | ||||
18.75 |
5 | 15.400 ± 1.650 | Value less than 0.0001 | ||||
37.5 |
5 | 22.300 ± 1.070 | Value less than 0.0001 | ||||
37.5 |
5 | 22.300 ± 1.070 | Value less than 0.0001 | ||||
75 |
5 | 39.200 ± 3.120 | Value less than 0.0001 | ||||
75 |
5 | 39.200 ± 3.120 | Value less than 0.0001 |
Start Date | Sample Collection Time | Sex | Cell | Methodology Used | Dosing Regimen | Route | Trend Test P-Value |
---|---|---|---|---|---|---|---|
1991-05-06 | 48 hour | Male | PCE | Slide Scoring | Intraperitoneal Injection x 1, 48 hour | Intraperitoneal Injection |
Dose (mg/kg) | Number of Animals Scored | Mean Percent PCE ± SEM | Pairwise P | ||||
---|---|---|---|---|---|---|---|
Vehicle Control | Phosphate Buffered Saline | 0 |
5 | 47.800 ± 2.010 | |||
0 |
5 | 47.800 ± 2.010 | |||||
Test Chemical | Cyclophosphamide monohydrate | 9.375 |
5 | 32.700 ± 5.360 | |||
9.375 |
5 | 32.700 ± 5.360 | |||||
18.75 |
5 | 42.600 ± 3.820 | |||||
18.75 |
5 | 42.600 ± 3.820 | |||||
37.5 |
5 | 26.800 ± 2.840 | |||||
37.5 |
5 | 26.800 ± 2.840 | |||||
75 |
5 | 18.400 ± 2.320 | |||||
75 |
5 | 18.400 ± 2.320 |
Bone Marrow
Start Date | Sample Collection Time | Sex | Cell | Methodology Used | Dosing Regimen | Route | Trend Test P-Value |
---|---|---|---|---|---|---|---|
1991-05-06 | 48 hour | Male | PCE | Slide Scoring | Intraperitoneal Injection x 1, 48 hour | Intraperitoneal Injection | 0.000 |
Dose (mg/kg) | Number of Animals Scored | Mean MN-PCE/1000 PCE ± SEM | Pairwise P | ||||
---|---|---|---|---|---|---|---|
Vehicle Control | Phosphate Buffered Saline | 0 |
5 | 2.200 ± 0.250 | |||
0 |
5 | 2.200 ± 0.250 | |||||
Test Chemical | Cyclophosphamide monohydrate | 1.875 |
5 | 3.000 ± 0.590 | 0.133 | ||
1.875 |
5 | 3.000 ± 0.590 | 0.133 | ||||
3.75 |
5 | 7.400 ± 0.530 | Value less than 0.0001 | ||||
3.75 |
5 | 7.400 ± 0.530 | Value less than 0.0001 | ||||
7.5 |
5 | 12.400 ± 1.620 | Value less than 0.0001 | ||||
7.5 |
5 | 12.400 ± 1.620 | Value less than 0.0001 | ||||
15 |
5 | 28.600 ± 3.180 | Value less than 0.0001 | ||||
15 |
5 | 28.600 ± 3.180 | Value less than 0.0001 |
Start Date | Sample Collection Time | Sex | Cell | Methodology Used | Dosing Regimen | Route | Trend Test P-Value |
---|---|---|---|---|---|---|---|
1991-05-06 | 48 hour | Male | PCE | Slide Scoring | Intraperitoneal Injection x 1, 48 hour | Intraperitoneal Injection |
Dose (mg/kg) | Number of Animals Scored | Mean Percent PCE ± SEM | Pairwise P | ||||
---|---|---|---|---|---|---|---|
Vehicle Control | Phosphate Buffered Saline | 0 |
5 | 30.700 ± 3.070 | |||
0 |
5 | 30.700 ± 3.070 | |||||
Test Chemical | Cyclophosphamide monohydrate | 1.875 |
5 | 25.600 ± 2.620 | |||
1.875 |
5 | 25.600 ± 2.620 | |||||
3.75 |
5 | 26.500 ± 3.090 | |||||
3.75 |
5 | 26.500 ± 3.090 | |||||
7.5 |
5 | 30.600 ± 4.770 | |||||
7.5 |
5 | 30.600 ± 4.770 | |||||
15 |
5 | 21.900 ± 3.470 | |||||
15 |
5 | 21.900 ± 3.470 |
Bone Marrow
Start Date | Sample Collection Time | Sex | Cell | Methodology Used | Dosing Regimen | Route | Trend Test P-Value |
---|---|---|---|---|---|---|---|
1991-05-07 | 24 hour | Male | PCE | Slide Scoring | Intraperitoneal Injection x 3, 72 hour | Intraperitoneal Injection | 0.000 |
Dose (mg/kg) | Number of Animals Scored | Mean MN-PCE/1000 PCE ± SEM | Pairwise P | ||||
---|---|---|---|---|---|---|---|
Vehicle Control | Phosphate Buffered Saline | 0 |
5 | 2.600 ± 0.330 | |||
0 |
5 | 2.600 ± 0.330 | |||||
Test Chemical | Cyclophosphamide monohydrate | 9.375 |
5 | 10.700 ± 1.460 | Value less than 0.0001 | ||
9.375 |
5 | 10.700 ± 1.460 | Value less than 0.0001 | ||||
37.5 |
3 | 34.830 ± 4.180 | Value less than 0.0001 | ||||
37.5 |
3 | 34.830 ± 4.180 | Value less than 0.0001 | ||||
75 |
5 | 35.200 ± 1.720 | Value less than 0.0001 | ||||
75 |
5 | 35.200 ± 1.720 | Value less than 0.0001 |
Start Date | Sample Collection Time | Sex | Cell | Methodology Used | Dosing Regimen | Route | Trend Test P-Value |
---|---|---|---|---|---|---|---|
1991-05-07 | 24 hour | Male | PCE | Slide Scoring | Intraperitoneal Injection x 3, 72 hour | Intraperitoneal Injection |
Dose (mg/kg) | Number of Animals Scored | Mean Percent PCE ± SEM | Pairwise P | ||||
---|---|---|---|---|---|---|---|
Vehicle Control | Phosphate Buffered Saline | 0 |
5 | 36.200 ± 2.700 | |||
0 |
5 | 36.200 ± 2.700 | |||||
Test Chemical | Cyclophosphamide monohydrate | 9.375 |
5 | 26.000 ± 2.820 | |||
9.375 |
5 | 26.000 ± 2.820 | |||||
37.5 |
3 | 39.000 ± 2.020 | |||||
37.5 |
3 | 39.000 ± 2.020 | |||||
75 |
5 | 7.600 ± 0.870 | |||||
75 |
5 | 7.600 ± 0.870 |
Bone Marrow
Start Date | Sample Collection Time | Sex | Cell | Methodology Used | Dosing Regimen | Route | Trend Test P-Value |
---|---|---|---|---|---|---|---|
1991-05-07 | 24 hour | Male | PCE | Slide Scoring | Intraperitoneal Injection x 3, 72 hour | Intraperitoneal Injection | 0.000 |
Dose (mg/kg) | Number of Animals Scored | Mean MN-PCE/1000 PCE ± SEM | Pairwise P | ||||
---|---|---|---|---|---|---|---|
Vehicle Control | Phosphate Buffered Saline | 0 |
5 | 3.600 ± 0.480 | |||
0 |
5 | 3.600 ± 0.480 | |||||
Test Chemical | Cyclophosphamide monohydrate | 1.875 |
5 | 5.100 ± 0.800 | 0.229 | ||
1.875 |
5 | 5.100 ± 0.800 | 0.229 | ||||
3.75 |
5 | 7.900 ± 1.330 | 0.032 | ||||
3.75 |
5 | 7.900 ± 1.330 | 0.032 | ||||
7.5 |
5 | 16.900 ± 2.530 | Value less than 0.0001 | ||||
7.5 |
5 | 16.900 ± 2.530 | Value less than 0.0001 | ||||
15 |
5 | 19.500 ± 5.440 | Value less than 0.0001 | ||||
15 |
5 | 19.500 ± 5.440 | Value less than 0.0001 |
Start Date | Sample Collection Time | Sex | Cell | Methodology Used | Dosing Regimen | Route | Trend Test P-Value |
---|---|---|---|---|---|---|---|
1991-05-07 | 24 hour | Male | PCE | Slide Scoring | Intraperitoneal Injection x 3, 72 hour | Intraperitoneal Injection |
Dose (mg/kg) | Number of Animals Scored | Mean Percent PCE ± SEM | Pairwise P | ||||
---|---|---|---|---|---|---|---|
Vehicle Control | Phosphate Buffered Saline | 0 |
5 | 34.700 ± 4.740 | |||
0 |
5 | 34.700 ± 4.740 | |||||
Test Chemical | Cyclophosphamide monohydrate | 1.875 |
5 | 26.000 ± 5.860 | |||
1.875 |
5 | 26.000 ± 5.860 | |||||
3.75 |
5 | 21.400 ± 2.710 | |||||
3.75 |
5 | 21.400 ± 2.710 | |||||
7.5 |
5 | 21.100 ± 1.440 | |||||
7.5 |
5 | 21.100 ± 1.440 | |||||
15 |
5 | 7.700 ± 1.140 | |||||
15 |
5 | 7.700 ± 1.140 |
Bone Marrow
Start Date | Sample Collection Time | Sex | Cell | Methodology Used | Dosing Regimen | Route | Trend Test P-Value |
---|---|---|---|---|---|---|---|
1991-12-16 | 24 hour | Male | PCE | Slide Scoring | Gavage x 1, 24 hour | Gavage | 0.010 |
Dose (mg/kg) | Number of Animals Scored | Mean MN-PCE/1000 PCE ± SEM | Pairwise P | ||||
---|---|---|---|---|---|---|---|
Vehicle Control | Phosphate Buffered Saline | 0 |
5 | 1.900 ± 0.510 | |||
Test Chemical | Cyclophosphamide monohydrate | 25 |
5 | 13.500 ± 2.740 | Value less than 0.0001 | ||
50 |
5 | 14.100 ± 2.500 | Value less than 0.0001 | ||||
100 |
5 | 10.400 ± 2.090 | Value less than 0.0001 |
Start Date | Sample Collection Time | Sex | Cell | Methodology Used | Dosing Regimen | Route | Trend Test P-Value |
---|---|---|---|---|---|---|---|
1991-12-16 | 24 hour | Male | PCE | Slide Scoring | Gavage x 1, 24 hour | Gavage |
Dose (mg/kg) | Number of Animals Scored | Mean Percent PCE ± SEM | Pairwise P | ||||
---|---|---|---|---|---|---|---|
Vehicle Control | Phosphate Buffered Saline | 0 |
5 | 31.700 ± 3.480 | |||
Test Chemical | Cyclophosphamide monohydrate | 25 |
5 | 32.200 ± 1.790 | |||
50 |
5 | 33.100 ± 4.210 | |||||
100 |
5 | 25.500 ± 3.100 |
Bone Marrow
Start Date | Sample Collection Time | Sex | Cell | Methodology Used | Dosing Regimen | Route | Trend Test P-Value |
---|---|---|---|---|---|---|---|
1991-12-16 | 48 hour | Male | PCE | Slide Scoring | Gavage x 1, 48 hour | Gavage | 0.000 |
Dose (mg/kg) | Number of Animals Scored | Mean MN-PCE/1000 PCE ± SEM | Pairwise P | ||||
---|---|---|---|---|---|---|---|
Vehicle Control | Phosphate Buffered Saline | 0 |
5 | 1.900 ± 0.430 | |||
Test Chemical | Cyclophosphamide monohydrate | 25 |
5 | 21.700 ± 2.470 | Value less than 0.0001 | ||
50 |
4 | 42.500 ± 8.220 | Value less than 0.0001 | ||||
100 |
5 | 37.600 ± 4.770 | Value less than 0.0001 |
Start Date | Sample Collection Time | Sex | Cell | Methodology Used | Dosing Regimen | Route | Trend Test P-Value |
---|---|---|---|---|---|---|---|
1991-12-16 | 48 hour | Male | PCE | Slide Scoring | Gavage x 1, 48 hour | Gavage |
Dose (mg/kg) | Number of Animals Scored | Mean Percent PCE ± SEM | Pairwise P | ||||
---|---|---|---|---|---|---|---|
Vehicle Control | Phosphate Buffered Saline | 0 |
5 | 30.500 ± 3.080 | |||
Test Chemical | Cyclophosphamide monohydrate | 25 |
5 | 25.000 ± 1.850 | |||
50 |
4 | 16.750 ± 2.360 | |||||
100 |
5 | 15.900 ± 2.230 |
Bone Marrow
Start Date | Sample Collection Time | Sex | Cell | Methodology Used | Dosing Regimen | Route | Trend Test P-Value |
---|---|---|---|---|---|---|---|
1992-02-10 | 24 hour | Male | PCE | Slide Scoring | Gavage x 3, 72 hour | Gavage | 0.000 |
Dose (mg/kg) | Number of Animals Scored | Mean MN-PCE/1000 PCE ± SEM | Pairwise P | ||||
---|---|---|---|---|---|---|---|
Vehicle Control | Corn Oil | 0 |
5 | 0.900 ± 0.330 | |||
Test Chemical | Cyclophosphamide monohydrate | 25 |
4 | 16.130 ± 6.520 | 0.000 | ||
50 |
0.000 ± 0.000 | ||||||
100 |
0.000 ± 0.000 |
Start Date | Sample Collection Time | Sex | Cell | Methodology Used | Dosing Regimen | Route | Trend Test P-Value |
---|---|---|---|---|---|---|---|
1992-02-10 | 24 hour | Male | PCE | Slide Scoring | Gavage x 3, 72 hour | Gavage |
Dose (mg/kg) | Number of Animals Scored | Mean Percent PCE ± SEM | Pairwise P | ||||
---|---|---|---|---|---|---|---|
Vehicle Control | Corn Oil | 0 |
5 | 24.700 ± 2.960 | |||
Test Chemical | Cyclophosphamide monohydrate | 25 |
4 | 12.880 ± 3.350 | |||
50 |
0.000 ± 0.000 | ||||||
100 |
0.000 ± 0.000 |
Bone Marrow
Start Date | Sample Collection Time | Sex | Cell | Methodology Used | Dosing Regimen | Route | Trend Test P-Value |
---|---|---|---|---|---|---|---|
1992-02-18 | 24 hour | Male | PCE | Slide Scoring | Gavage x 1, 24 hour | Gavage | 0.000 |
Dose (mg/kg) | Number of Animals Scored | Mean MN-PCE/1000 PCE ± SEM | Pairwise P | ||||
---|---|---|---|---|---|---|---|
Vehicle Control | Corn Oil | 0 |
5 | 1.300 ± 0.340 | |||
Test Chemical | Cyclophosphamide monohydrate | 25 |
5 | 8.000 ± 1.920 | Value less than 0.0001 | ||
50 |
4 | 15.380 ± 1.420 | Value less than 0.0001 | ||||
100 |
5 | 17.800 ± 2.640 | Value less than 0.0001 |
Start Date | Sample Collection Time | Sex | Cell | Methodology Used | Dosing Regimen | Route | Trend Test P-Value |
---|---|---|---|---|---|---|---|
1992-02-18 | 24 hour | Male | PCE | Slide Scoring | Gavage x 1, 24 hour | Gavage |
Dose (mg/kg) | Number of Animals Scored | Mean Percent PCE ± SEM | Pairwise P | ||||
---|---|---|---|---|---|---|---|
Vehicle Control | Corn Oil | 0 |
5 | 40.400 ± 1.220 | |||
Test Chemical | Cyclophosphamide monohydrate | 25 |
5 | 34.700 ± 2.550 | |||
50 |
4 | 40.250 ± 1.390 | |||||
100 |
5 | 36.500 ± 2.060 |
Bone Marrow
Start Date | Sample Collection Time | Sex | Cell | Methodology Used | Dosing Regimen | Route | Trend Test P-Value |
---|---|---|---|---|---|---|---|
1992-02-19 | 48 hour | Male | PCE | Slide Scoring | Gavage x 1, 48 hour | Gavage | 0.000 |
Dose (mg/kg) | Number of Animals Scored | Mean MN-PCE/1000 PCE ± SEM | Pairwise P | ||||
---|---|---|---|---|---|---|---|
Vehicle Control | Corn Oil | 0 |
5 | 1.500 ± 0.270 | |||
Test Chemical | Cyclophosphamide monohydrate | 25 |
5 | 23.400 ± 1.530 | Value less than 0.0001 | ||
50 |
5 | 29.300 ± 1.300 | Value less than 0.0001 | ||||
100 |
5 | 22.200 ± 3.040 | Value less than 0.0001 |
Start Date | Sample Collection Time | Sex | Cell | Methodology Used | Dosing Regimen | Route | Trend Test P-Value |
---|---|---|---|---|---|---|---|
1992-02-19 | 48 hour | Male | PCE | Slide Scoring | Gavage x 1, 48 hour | Gavage |
Dose (mg/kg) | Number of Animals Scored | Mean Percent PCE ± SEM | Pairwise P | ||||
---|---|---|---|---|---|---|---|
Vehicle Control | Corn Oil | 0 |
5 | 24.100 ± 4.650 | |||
Test Chemical | Cyclophosphamide monohydrate | 25 |
5 | 21.000 ± 2.860 | |||
50 |
5 | 15.700 ± 2.960 | |||||
100 |
5 | 21.300 ± 2.540 |
Bone Marrow
Start Date | Sample Collection Time | Sex | Cell | Methodology Used | Dosing Regimen | Route | Trend Test P-Value |
---|---|---|---|---|---|---|---|
1992-03-09 | 24 hour | Male | PCE | Slide Scoring | Gavage x 3, 72 hour | Gavage | 0.000 |
Dose (mg/kg) | Number of Animals Scored | Mean MN-PCE/1000 PCE ± SEM | Pairwise P | ||||
---|---|---|---|---|---|---|---|
Vehicle Control | Phosphate Buffered Saline | 0 |
5 | 0.900 ± 0.240 | |||
Test Chemical | Cyclophosphamide monohydrate | 25 |
0.000 ± 0.000 | ||||
50 |
0.000 ± 0.000 | ||||||
100 |
0.000 ± 0.000 |
Start Date | Sample Collection Time | Sex | Cell | Methodology Used | Dosing Regimen | Route | Trend Test P-Value |
---|---|---|---|---|---|---|---|
1992-03-09 | 24 hour | Male | PCE | Slide Scoring | Gavage x 3, 72 hour | Gavage |
Dose (mg/kg) | Number of Animals Scored | Mean Percent PCE ± SEM | Pairwise P | ||||
---|---|---|---|---|---|---|---|
Vehicle Control | Phosphate Buffered Saline | 0 |
5 | 26.500 ± 2.560 | |||
Test Chemical | Cyclophosphamide monohydrate | 25 |
0.000 ± 0.000 | ||||
50 |
0.000 ± 0.000 | ||||||
100 |
0.000 ± 0.000 |