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Study Information
Study Attribute Value
CEBS Accession Number: 002-01948-0001-0000-5
Chemical Name: D-Mannitol
CASRN: 69-65-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 308644_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 04/09/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1049 407 0.388 8.14 26.5 0.000
Test Chemical D-Mannitol 
160         
 50 1047 425 0.406 8.50 26.5 4.622 
500         
 50 1046 401 0.383 8.02 26.5 -1.192 
1600         
 50 1047 403 0.385 8.06 26.5 -0.794 
5000         
 50 1048 416 0.397 8.32 26.5 2.309
Positive Control Mitomycin-C 
 0.001     
 50 1048 584 0.557 11.68 26.5 43.626
Mitomycin-C 
 0.005     
 10 210 191 0.910 19.10 26.5 134.420
Trend: -0.050        
Probability: 0.520        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 04/09/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1049 422 0.402 8.44 26.5 0.000
Test Chemical D-Mannitol 
160         
 50 1052 434 0.413 8.68 26.5 2.550 
500         
 50 1047 419 0.400 8.38 26.5 -0.521 
1600         
 50 1049 432 0.412 8.64 26.5 2.370 
5000         
 50 1052 393 0.374 7.86 26.5 -7.138
Positive Control Cyclophosphamide 
 0.3       
 50 1048 839 0.801 16.78 26.5 99.005
Cyclophosphamide 
 0.6       
 10 208 277 1.332 27.70 26.5 231.039
Trend: -0.942        
Probability: 0.827