Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01948-0002-0000-6 |
Chemical Name: | D-Mannitol |
CASRN: | 69-65-8 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 308644_CA |
Study Result: | Negative |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Negative |
Induced Rat Liver S9 | 1_S9 | Negative |
Dose µg/mL |
Total Cells Examined |
Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs |
Abs Per Cell |
% Cells With Abs |
No. of Abs. |
Abs Per Cell |
% Cells With Abs |
No. of Abs. |
Abs Per Cell |
% Cells With Abs |
No. of Abs. |
Abs Per Cell |
% Cells With Abs |
||||
Vehicle Control: | Medium | 0 |
200 | 5 | 0.025 | 3.0 | 1 | 0.005 | 1.0 | 4 | 0.020 | 2.0 | 0 | 0.000 | 0.0 |
Test Chemical: | D-Mannitol | 1600 |
200 | 4 | 0.020 | 2.0 | 2 | 0.010 | 1.0 | 2 | 0.010 | 1.0 | 0 | 0.000 | 0.0 |
3000 |
200 | 2 | 0.010 | 1.0 | 1 | 0.005 | 1.0 | 1 | 0.005 | 1.0 | 0 | 0.000 | 0.0 | ||
5000 |
200 | 3 | 0.015 | 2.0 | 0 | 0.000 | 0.0 | 3 | 0.015 | 2.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 0.125 |
200 | 43 | 0.215 | 19.0 | 22 | 0.110 | 11.0 | 21 | 0.105 | 10.0 | 0 | 0.000 | 0.0 |
Mitomycin-C | 0.25 |
50 | 19 | 0.380 | 24.0 | 10 | 0.200 | 16.0 | 9 | 0.180 | 16.0 | 0 | 0.000 | 0.0 | |
Trend: | -0.940 | -1.069 | -0.027 | ||||||||||||
Probability: | 0.826 | 0.857 | 0.511 |
Dose µg/mL |
Total Cells Examined |
Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs |
Abs Per Cell |
% Cells With Abs |
No. of Abs. |
Abs Per Cell |
% Cells With Abs |
No. of Abs. |
Abs Per Cell |
% Cells With Abs |
No. of Abs. |
Abs Per Cell |
% Cells With Abs |
||||
Vehicle Control: | Medium | 0 |
200 | 2 | 0.010 | 1.0 | 1 | 0.005 | 1.0 | 1 | 0.005 | 1.0 | 0 | 0.000 | 0.0 |
Test Chemical: | D-Mannitol | 1600 |
200 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 |
3000 |
200 | 1 | 0.005 | 1.0 | 0 | 0.000 | 0.0 | 1 | 0.005 | 1.0 | 0 | 0.000 | 0.0 | ||
5000 |
200 | 4 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | 4 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 7.5 |
200 | 113 | 0.565 | 41.0 | 23 | 0.115 | 10.0 | 90 | 0.450 | 36.0 | 0 | 0.000 | 0.0 |
Cyclophosphamide | 10 |
50 | 32 | 0.640 | 44.0 | 2 | 0.040 | 4.0 | 29 | 0.580 | 42.0 | 1 | 0.020 | 1.0 | |
Trend: | 1.257 | -1.911 | 1.257 | ||||||||||||
Probability: | 0.104 | 0.972 | 0.104 |