Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01948-0003-0000-7 |
Chemical Name: | D-Mannitol |
CASRN: | 69-65-8 |
NTP Study Type: | Genetic Toxicology - Micronucleus |
NTP Study ID: | 090264 |
Strain and Species: | B6C3F1 Mouse |
Study Result: | Male: Negative |
Bone Marrow
Start Date | Sample Collection Time | Sex | Cell | Methodology Used | Dosing Regimen | Route | Trend Test P-Value |
---|---|---|---|---|---|---|---|
1989-05-15 | 24 hour | Male | PCE | Slide Scoring | Intraperitoneal Injection x 3, 72 hour | Intraperitoneal Injection | 0.561 |
Dose (mg/kg) | Number of Animals Scored | Mean MN-PCE/1000 PCE ± SEM | Pairwise P | ||||
---|---|---|---|---|---|---|---|
Vehicle Control | Phosphate Buffered Saline | 0 |
5 | 2.700 ± 0.580 | |||
Test Chemical | D-Mannitol | 500 |
5 | 2.200 ± 0.770 | 0.704 | ||
1000 |
5 | 4.400 ± 1.100 | 0.065 | ||||
2000 |
5 | 2.200 ± 0.300 | 0.704 | ||||
Positive Control | Mitomycin-C | 0.2 |
5 | 6.500 ± 0.570 | Value less than 0.0001 |
Start Date | Sample Collection Time | Sex | Cell | Methodology Used | Dosing Regimen | Route | Trend Test P-Value |
---|---|---|---|---|---|---|---|
1989-05-15 | 24 hour | Male | PCE | Slide Scoring | Intraperitoneal Injection x 3, 72 hour | Intraperitoneal Injection |
Dose (mg/kg) | Number of Animals Scored | Mean Percent PCE ± SEM | Pairwise P | ||||
---|---|---|---|---|---|---|---|
Vehicle Control | Phosphate Buffered Saline | 0 |
5 | 60.200 ± 6.280 | |||
Test Chemical | D-Mannitol | 500 |
5 | 58.500 ± 4.200 | |||
1000 |
5 | 61.400 ± 2.790 | |||||
2000 |
5 | 58.400 ± 3.080 | |||||
Positive Control | Mitomycin-C | 0.2 |
5 | 58.700 ± 2.560 |
Bone Marrow
Start Date | Sample Collection Time | Sex | Cell | Methodology Used | Dosing Regimen | Route | Trend Test P-Value |
---|---|---|---|---|---|---|---|
1989-12-12 | 24 hour | Male | PCE | Slide Scoring | Intraperitoneal Injection x 3, 72 hour | Intraperitoneal Injection | 0.481 |
Dose (mg/kg) | Number of Animals Scored | Mean MN-PCE/1000 PCE ± SEM | Pairwise P | ||||
---|---|---|---|---|---|---|---|
Vehicle Control | Phosphate Buffered Saline | 0 |
5 | 3.000 ± 0.670 | |||
Test Chemical | D-Mannitol | 1000 |
5 | 3.400 ± 0.530 | 0.308 | ||
2000 |
4 | 2.500 ± 0.680 | 0.737 | ||||
3000 |
5 | 3.300 ± 0.680 | 0.353 | ||||
Positive Control | Mitomycin-C | 0.2 |
5 | 6.100 ± 1.730 | 0.001 |
Start Date | Sample Collection Time | Sex | Cell | Methodology Used | Dosing Regimen | Route | Trend Test P-Value |
---|---|---|---|---|---|---|---|
1989-12-12 | 24 hour | Male | PCE | Slide Scoring | Intraperitoneal Injection x 3, 72 hour | Intraperitoneal Injection |
Dose (mg/kg) | Number of Animals Scored | Mean Percent PCE ± SEM | Pairwise P | ||||
---|---|---|---|---|---|---|---|
Vehicle Control | Phosphate Buffered Saline | 0 |
5 | 60.200 ± 1.440 | |||
Test Chemical | D-Mannitol | 1000 |
5 | 57.900 ± 1.680 | |||
2000 |
4 | 62.130 ± 2.200 | |||||
3000 |
5 | 58.600 ± 3.050 | |||||
Positive Control | Mitomycin-C | 0.2 |
5 | 58.400 ± 2.440 |
Blood
Start Date | Sample Collection Time | Sex | Cell | Methodology Used | Dosing Regimen | Route | Trend Test P-Value |
---|---|---|---|---|---|---|---|
1989-04-24 | 48 hour | Male | PCE | Slide Scoring | Intraperitoneal Injection x 3, 96 hour | Intraperitoneal Injection | 0.224 |
Dose (mg/kg) | Number of Animals Scored | Mean MN-PCE/1000 PCE ± SEM | Pairwise P | ||||
---|---|---|---|---|---|---|---|
Vehicle Control | Phosphate Buffered Saline | 0 |
5 | 2.300 ± 0.440 | |||
Test Chemical | D-Mannitol | 1000 |
5 | 3.300 ± 0.940 | 0.167 | ||
2000 |
5 | 3.100 ± 0.830 | 0.216 |
Start Date | Sample Collection Time | Sex | Cell | Methodology Used | Dosing Regimen | Route | Trend Test P-Value |
---|---|---|---|---|---|---|---|
1989-04-24 | 48 hour | Male | PCE | Slide Scoring | Intraperitoneal Injection x 3, 96 hour | Intraperitoneal Injection |
Dose (mg/kg) | Number of Animals Scored | Mean Percent PCE ± SEM | Pairwise P | ||||
---|---|---|---|---|---|---|---|
Vehicle Control | Phosphate Buffered Saline | 0 |
5 | 2.240 ± 0.280 | |||
Test Chemical | D-Mannitol | 1000 |
5 | 4.120 ± 0.600 | |||
2000 |
5 | 3.680 ± 0.660 |
Blood
Start Date | Sample Collection Time | Sex | Cell | Methodology Used | Dosing Regimen | Route | Trend Test P-Value |
---|---|---|---|---|---|---|---|
1989-12-12 | 24 hour | Male | PCE | Slide Scoring | Intraperitoneal Injection x 3, 72 hour | Intraperitoneal Injection | 0.552 |
Dose (mg/kg) | Number of Animals Scored | Mean MN-PCE/1000 PCE ± SEM | Pairwise P | ||||
---|---|---|---|---|---|---|---|
Vehicle Control | Phosphate Buffered Saline | 0 |
5 | 2.600 ± 0.660 | |||
Test Chemical | D-Mannitol | 1000 |
5 | 2.600 ± 0.620 | 0.500 | ||
2000 |
5 | 3.200 ± 0.560 | 0.215 | ||||
3000 |
5 | 2.300 ± 0.540 | 0.666 | ||||
Positive Control | Mitomycin-C | 0.2 |
5 | 5.600 ± 1.130 | 0.001 |
Start Date | Sample Collection Time | Sex | Cell | Methodology Used | Dosing Regimen | Route | Trend Test P-Value |
---|---|---|---|---|---|---|---|
1989-12-12 | 24 hour | Male | PCE | Slide Scoring | Intraperitoneal Injection x 3, 72 hour | Intraperitoneal Injection |
Dose (mg/kg) | Number of Animals Scored | Mean Percent PCE ± SEM | Pairwise P | ||||
---|---|---|---|---|---|---|---|
Vehicle Control | Phosphate Buffered Saline | 0 |
5 | 4.200 ± 0.240 | |||
Test Chemical | D-Mannitol | 1000 |
5 | 3.920 ± 0.290 | |||
2000 |
5 | 3.940 ± 0.210 | |||||
3000 |
5 | 4.300 ± 0.370 | |||||
Positive Control | Mitomycin-C | 0.2 |
5 | 3.860 ± 0.480 |