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Study Information
Study Attribute Value
CEBS Accession Number: 002-01996-0005-0000-2
Chemical Name: Dibromoacetic acid
CASRN: 631-64-1
NTP Study Type: Genetic Toxicology - Micronucleus
NTP Study ID: A03046
Strain and Species: B6C3F1 Mouse
Study Result: Male: Positive; Female: Negative

Blood

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
1999-06-18 24 hour Male PCE Slide Scoring Dosed-Water x 90, 90 day Dosed-Water 0.217
  Dose (mg/L) Number of Animals Scored Mean MN-PCE/1000 PCE ± SEM Pairwise P
Vehicle Control Water 
 0         
 10 1.800 ± 0.290
Test Chemical Dibromoacetic acid 
125         
 0.000 ± 0.000 
250         
 0.000 ± 0.000 
500         
 0.000 ± 0.000 
1000         
 0.000 ± 0.000 
2000         
 10 2.300 ± 0.370 0.217

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
1999-06-18 24 hour Male PCE Slide Scoring Dosed-Water x 90, 90 day Dosed-Water
  Dose (mg/L) Number of Animals Scored Mean Percent PCE ± SEM Pairwise P
Vehicle Control Water 
 0         
 10 3.020 ± 0.150
Test Chemical Dibromoacetic acid 
125         
 0.000 ± 0.000 
250         
 0.000 ± 0.000 
500         
 0.000 ± 0.000 
1000         
 0.000 ± 0.000 
2000         
 10 2.970 ± 0.080

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
1999-06-18 24 hour Male NCE Slide Scoring Dosed-Water x 90, 90 day Dosed-Water 0.010
  Dose (mg/L) Number of Animals Scored Mean MN-NCE/1000 NCE ± SEM Pairwise P
Vehicle Control Water 
 0         
 10 1.800 ± 0.330
Test Chemical Dibromoacetic acid 
125         
 10 2.300 ± 0.470 0.217 
250         
 10 3.300 ± 0.560 0.018 
500         
 10 3.200 ± 0.420 0.024 
1000         
 9 4.000 ± 0.500 0.002 
2000         
 10 3.600 ± 0.560 0.007

Blood

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
1999-06-19 24 hour Female PCE Slide Scoring Dosed-Water x 90, 90 day Dosed-Water 0.010
  Dose (mg/L) Number of Animals Scored Mean MN-PCE/1000 PCE ± SEM Pairwise P
Vehicle Control Water 
 0         
 10 0.900 ± 0.230
Test Chemical Dibromoacetic acid 
125         
 0.000 ± 0.000 
250         
 0.000 ± 0.000 
500         
 0.000 ± 0.000 
1000         
 0.000 ± 0.000 
2000         
 10 2.200 ± 0.420 0.010

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
1999-06-19 24 hour Female PCE Slide Scoring Dosed-Water x 90, 90 day Dosed-Water
  Dose (mg/L) Number of Animals Scored Mean Percent PCE ± SEM Pairwise P
Vehicle Control Water 
 0         
 10 2.770 ± 0.100
Test Chemical Dibromoacetic acid 
125         
 0.000 ± 0.000 
250         
 0.000 ± 0.000 
500         
 0.000 ± 0.000 
1000         
 0.000 ± 0.000 
2000         
 10 2.730 ± 0.130

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
1999-06-19 24 hour Female NCE Slide Scoring Dosed-Water x 90, 90 day Dosed-Water 0.397
  Dose (mg/L) Number of Animals Scored Mean MN-NCE/1000 NCE ± SEM Pairwise P
Vehicle Control Water 
 0         
 10 2.300 ± 0.560
Test Chemical Dibromoacetic acid 
125         
 10 2.100 ± 0.430 0.619 
250         
 10 1.700 ± 0.300 0.829 
500         
 10 2.100 ± 0.280 0.619 
1000         
 10 2.200 ± 0.440 0.559 
2000         
 10 2.200 ± 0.290 0.559