Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-02007-0004-0000-5 |
Chemical Name: | Dichloroacetic acid |
CASRN: | 79-43-6 |
NTP Study Type: | Genetic Toxicology - Micronucleus |
NTP Study ID: | A15985 |
Strain and Species: | TGAC (FVB/N) HEMIZYGOUS Mouse |
Study Result: | Male: Negative; Female: Negative |
Blood
Start Date | Sample Collection Time | Sex | Cell | Methodology Used | Dosing Regimen | Route | Trend Test P-Value |
---|---|---|---|---|---|---|---|
2000-11-06 | 24 hour | Female | NCE | Slide Scoring | Dermal x 130, 26 week | Dermal | 0.857 |
Dose (mg/kg) | Number of Animals Scored | Mean MN-NCE/1000 NCE ± SEM | Pairwise P | ||||
---|---|---|---|---|---|---|---|
Vehicle Control | Acetone | 0 |
11 | 1.140 ± 0.200 | |||
Test Chemical | Dichloroacetic acid | 31.25 |
12 | 1.580 ± 0.170 | 0.098 | ||
125 |
14 | 1.250 ± 0.230 | 0.358 | ||||
500 |
15 | 1.070 ± 0.150 | 0.594 |
Blood
Start Date | Sample Collection Time | Sex | Cell | Methodology Used | Dosing Regimen | Route | Trend Test P-Value |
---|---|---|---|---|---|---|---|
2000-11-06 | 24 hour | Male | NCE | Slide Scoring | Dermal x 130, 26 week | Dermal | 0.989 |
Dose (mg/kg) | Number of Animals Scored | Mean MN-NCE/1000 NCE ± SEM | Pairwise P | ||||
---|---|---|---|---|---|---|---|
Vehicle Control | Acetone | 0 |
13 | 1.350 ± 0.180 | |||
Test Chemical | Dichloroacetic acid | 31.25 |
14 | 1.250 ± 0.240 | 0.622 | ||
125 |
14 | 1.180 ± 0.160 | 0.708 | ||||
500 |
12 | 0.710 ± 0.160 | 0.987 |