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Study Information
Study Attribute Value
CEBS Accession Number: 002-02007-0005-0000-6
Chemical Name: Dichloroacetic acid
CASRN: 79-43-6
NTP Study Type: Genetic Toxicology - Micronucleus
NTP Study ID: A67778
Strain and Species: B6C3F1 Mouse
Study Result: Male: Negative; Female: Positive

Blood

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
2000-09-26 24 hour Male PCE Slide Scoring Dosed-Water x 90, 13 week Dosed-Water 0.550
  Dose (mg/L) Number of Animals Scored Mean MN-PCE/1000 PCE ± SEM Pairwise P
Vehicle Control Solvent 
 0         
 10 3.200 ± 0.610
Test Chemical Dichloroacetic acid 
67         
 0.000 ± 0.000 
125         
 0.000 ± 0.000 
250         
 0.000 ± 0.000 
500         
 0.000 ± 0.000 
1000         
 10 3.100 ± 0.620 0.550

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
2000-09-26 24 hour Male PCE Slide Scoring Dosed-Water x 90, 13 week Dosed-Water
  Dose (mg/L) Number of Animals Scored Mean Percent PCE ± SEM Pairwise P
Vehicle Control Solvent 
 0         
 10 3.030 ± 0.090
Test Chemical Dichloroacetic acid 
67         
 0.000 ± 0.000 
125         
 0.000 ± 0.000 
250         
 0.000 ± 0.000 
500         
 0.000 ± 0.000 
1000         
 10 2.320 ± 0.070

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
2000-09-26 24 hour Male NCE Slide Scoring Dosed-Water x 90, 13 week Dosed-Water 0.887
  Dose (mg/L) Number of Animals Scored Mean MN-NCE/1000 NCE ± SEM Pairwise P
Vehicle Control Solvent 
 0         
 10 2.300 ± 0.400
Test Chemical Dichloroacetic acid 
67         
 10 2.100 ± 0.430 0.619 
125         
 10 2.700 ± 0.420 0.286 
250         
 10 2.900 ± 0.430 0.202 
500         
 10 2.600 ± 0.310 0.334 
1000         
 10 1.600 ± 0.400 0.869

Blood

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
2000-09-27 24 hour Female PCE Slide Scoring Dosed-Water x 90, 13 week Dosed-Water 0.396
  Dose (mg/L) Number of Animals Scored Mean MN-PCE/1000 PCE ± SEM Pairwise P
Vehicle Control Solvent 
 0         
 10 2.800 ± 0.660
Test Chemical Dichloroacetic acid 
67         
 0.000 ± 0.000 
125         
 0.000 ± 0.000 
250         
 0.000 ± 0.000 
500         
 0.000 ± 0.000 
1000         
 10 3.000 ± 0.540 0.396

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
2000-09-27 24 hour Female PCE Slide Scoring Dosed-Water x 90, 13 week Dosed-Water
  Dose (mg/L) Number of Animals Scored Mean Percent PCE ± SEM Pairwise P
Vehicle Control Solvent 
 0         
 10 2.340 ± 0.080
Test Chemical Dichloroacetic acid 
67         
 0.000 ± 0.000 
125         
 0.000 ± 0.000 
250         
 0.000 ± 0.000 
500         
 0.000 ± 0.000 
1000         
 10 2.490 ± 0.110

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
2000-09-27 24 hour Female NCE Slide Scoring Dosed-Water x 90, 13 week Dosed-Water 0.007
  Dose (mg/L) Number of Animals Scored Mean MN-NCE/1000 NCE ± SEM Pairwise P
Vehicle Control Solvent 
 0         
 10 1.800 ± 0.420
Test Chemical Dichloroacetic acid 
67         
 10 2.000 ± 0.330 0.373 
125         
 10 2.300 ± 0.450 0.217 
250         
 10 2.000 ± 0.210 0.373 
500         
 10 2.600 ± 0.500 0.114 
1000         
 10 3.300 ± 0.520 0.018