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Study Information
Study Attribute Value
CEBS Accession Number: 002-02007-0007-0000-8
Chemical Name: Dichloroacetic acid
CASRN: 79-43-6
NTP Study Type: Genetic Toxicology - Micronucleus
NTP Study ID: A91472
Strain and Species: P53 +/- (C57BL/6) Mouse
Study Result: Male: Negative; Female: Negative

Blood

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
2000-10-12 24 hour Female NCE Slide Scoring Dosed-Water x 182, 26 week Dosed-Water 0.169
  Dose (mg/L) Number of Animals Scored Mean MN-NCE/1000 NCE ± SEM Pairwise P
Vehicle Control Water 
 0         
 15 1.000 ± 0.220
Test Chemical Dichloroacetic acid 
500         
 15 0.830 ± 0.120 0.750 
1000         
 14 1.040 ± 0.220 0.446 
2000         
 14 1.180 ± 0.210 0.257

Blood

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
2000-10-12 24 hour Male NCE Slide Scoring Dosed-Water x 182, 26 week Dosed-Water 0.384
  Dose (mg/L) Number of Animals Scored Mean MN-NCE/1000 NCE ± SEM Pairwise P
Vehicle Control Water 
 0         
 15 1.600 ± 0.200
Test Chemical Dichloroacetic acid 
500         
 15 1.900 ± 0.200 0.190 
1000         
 15 1.530 ± 0.190 0.582 
2000         
 15 1.800 ± 0.240 0.276