Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-02042-0012-0000-3 |
Chemical Name: | Diethylstilbestrol |
CASRN: | 56-53-1 |
NTP Study Type: | Genetic Toxicology - Micronucleus |
NTP Study ID: | A27424 |
Strain and Species: | BRCA1(+/+) Mouse |
Study Result: | Female: Positive |
Blood
Start Date | Sample Collection Time | Sex | Cell | Methodology Used | Dosing Regimen | Route | Trend Test P-Value |
---|---|---|---|---|---|---|---|
1997-12-01 | 24 hour | Female | PCE | Slide Scoring | Dosed-Feed x 182, 26 week | Dosed-Feed | 0.001 |
Dose (ppb) | Number of Animals Scored | Mean MN-PCE/1000 PCE ± SEM | Pairwise P | ||||
---|---|---|---|---|---|---|---|
Vehicle Control | Feed | 0 |
10 | 1.100 ± 0.380 | |||
Test Chemical | Diethylstilbestrol | 640 |
10 | 3.200 ± 0.710 | 0.001 |
Start Date | Sample Collection Time | Sex | Cell | Methodology Used | Dosing Regimen | Route | Trend Test P-Value |
---|---|---|---|---|---|---|---|
1997-12-01 | 24 hour | Female | PCE | Slide Scoring | Dosed-Feed x 182, 26 week | Dosed-Feed |
Dose (ppb) | Number of Animals Scored | Mean Percent PCE ± SEM | Pairwise P | ||||
---|---|---|---|---|---|---|---|
Vehicle Control | Feed | 0 |
10 | 1.190 ± 0.120 | |||
Test Chemical | Diethylstilbestrol | 640 |
10 | 1.960 ± 0.100 |
Start Date | Sample Collection Time | Sex | Cell | Methodology Used | Dosing Regimen | Route | Trend Test P-Value |
---|---|---|---|---|---|---|---|
1997-12-01 | 24 hour | Female | NCE | Slide Scoring | Dosed-Feed x 182, 26 week | Dosed-Feed | 0.001 |
Dose (ppb) | Number of Animals Scored | Mean MN-NCE/1000 NCE ± SEM | Pairwise P | ||||
---|---|---|---|---|---|---|---|
Vehicle Control | Feed | 0 |
10 | 0.400 ± 0.220 | |||
Test Chemical | Diethylstilbestrol | 640 |
10 | 1.900 ± 0.230 | 0.001 |