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Study Information
Study Attribute Value
CEBS Accession Number: 002-02128-0001-0000-6
Chemical Name: Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E Super; OTNE)
CASRN: 54464-57-2
NTP Study Type: Genetic Toxicology - Micronucleus
NTP Study ID: F28470
Strain and Species: F344/NTac Rat
Study Result: Male: Negative; Female: Negative

Blood

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
2006-03-13 24 hour Male PCE Flow Cytometry Dermal x 91, 13 week Dermal 0.045
  Dose (%) Number of Animals Scored Mean MN-PCE/1000 PCE ± SEM Pairwise P
Vehicle Control 95% Ethanol 
 0         
 5 0.380 ± 0.060
Test Chemical Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E Super; OTNE) 
6.25      
 5 0.430 ± 0.080 0.431 
12.5       
 5 0.360 ± 0.033 0.509 
25         
 5 0.650 ± 0.065 0.021 
50         
 5 0.500 ± 0.057 0.022

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
2006-03-13 24 hour Male PCE Flow Cytometry Dermal x 91, 13 week Dermal 0.025
  Dose (%) Number of Animals Scored Mean Percent PCE ± SEM Pairwise P
Vehicle Control 95% Ethanol 
 0         
 5 1.201 ± 0.069
Test Chemical Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E Super; OTNE) 
6.25      
 5 1.176 ± 0.028 1.000 
12.5       
 5 1.228 ± 0.032 1.000 
25         
 5 1.293 ± 0.073 1.000 
50         
 5 1.001 ± 0.075 0.022

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
2006-03-13 24 hour Male NCE Flow Cytometry Dermal x 91, 13 week Dermal 0.963
  Dose (%) Number of Animals Scored Mean MN-NCE/1000 NCE ± SEM Pairwise P
Vehicle Control 95% Ethanol 
 0         
 5 0.084 ± 0.010
Test Chemical Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E Super; OTNE) 
6.25      
 5 0.071 ± 0.012 0.980 
12.5       
 5 0.039 ± 0.005 0.993 
25         
 5 0.047 ± 0.003 0.996 
50         
 5 0.054 ± 0.008 0.997

Blood

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
2006-03-13 24 hour Male PCE Flow Cytometry Dermal x 91, 13 week Dermal
  Dose (%) Number of Animals Scored Mean MN-PCE/1000 PCE ± SEM Pairwise P
Untreated Control 
 0         
 5 0.380 ± 0.041
Test Chemical Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E Super; OTNE) 
100         
 5 0.430 ± 0.093 0.320

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
2006-03-13 24 hour Male PCE Flow Cytometry Dermal x 91, 13 week Dermal
  Dose (%) Number of Animals Scored Mean Percent PCE ± SEM Pairwise P
Untreated Control 
 0         
 5 1.124 ± 0.053
Test Chemical Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E Super; OTNE) 
100         
 5 1.111 ± 0.072 0.850

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
2006-03-13 24 hour Male NCE Flow Cytometry Dermal x 91, 13 week Dermal
  Dose (%) Number of Animals Scored Mean MN-NCE/1000 NCE ± SEM Pairwise P
Untreated Control 
 0         
 5 0.094 ± 0.013
Test Chemical Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E Super; OTNE) 
100         
 5 0.036 ± 0.005 0.969

Blood

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
2006-03-13 24 hour Male PCE Flow Cytometry Dermal x 91, 13 week Dermal
  Dose (%) Number of Animals Scored Mean MN-PCE/1000 PCE ± SEM Pairwise P
Vehicle Control 95% Ethanol 
 0         
 5 0.380 ± 0.060 0.502
Untreated Control 
 0         
 5 0.380 ± 0.041

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
2006-03-13 24 hour Male PCE Flow Cytometry Dermal x 91, 13 week Dermal
  Dose (%) Number of Animals Scored Mean Percent PCE ± SEM Pairwise P
Vehicle Control 95% Ethanol 
 0         
 5 1.201 ± 0.069 0.400
Untreated Control 
 0         
 5 1.124 ± 0.053

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
2006-03-13 24 hour Male NCE Flow Cytometry Dermal x 91, 13 week Dermal
  Dose (%) Number of Animals Scored Mean MN-NCE/1000 NCE ± SEM Pairwise P
Vehicle Control 95% Ethanol 
 0         
 5 0.084 ± 0.010 0.621
Untreated Control 
 0         
 5 0.094 ± 0.013

Blood

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
2006-03-14 24 hour Female PCE Flow Cytometry Dermal x 91, 13 week Dermal 0.454
  Dose (%) Number of Animals Scored Mean MN-PCE/1000 PCE ± SEM Pairwise P
Vehicle Control 95% Ethanol 
 0         
 5 0.580 ± 0.147
Test Chemical Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E Super; OTNE) 
6.25      
 5 0.400 ± 0.063 0.690 
12.5       
 5 0.550 ± 0.207 0.653 
25         
 5 0.580 ± 0.060 0.688 
50         
 5 0.520 ± 0.090 0.707

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
2006-03-14 24 hour Female PCE Flow Cytometry Dermal x 91, 13 week Dermal 0.214
  Dose (%) Number of Animals Scored Mean Percent PCE ± SEM Pairwise P
Vehicle Control 95% Ethanol 
 0         
 5 0.793 ± 0.074
Test Chemical Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E Super; OTNE) 
6.25      
 5 0.836 ± 0.122 1.000 
12.5       
 5 1.074 ± 0.105 0.375 
25         
 5 0.685 ± 0.036 1.000 
50         
 5 0.699 ± 0.048 1.000

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
2006-03-14 24 hour Female NCE Flow Cytometry Dermal x 91, 13 week Dermal 0.910
  Dose (%) Number of Animals Scored Mean MN-NCE/1000 NCE ± SEM Pairwise P
Vehicle Control 95% Ethanol 
 0         
 5 0.077 ± 0.027
Test Chemical Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E Super; OTNE) 
6.25      
 5 0.039 ± 0.005 1.000 
12.5       
 5 0.058 ± 0.015 1.000 
25         
 5 0.060 ± 0.011 1.000 
50         
 5 0.033 ± 0.004 1.000

Blood

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
2006-03-14 24 hour Female PCE Flow Cytometry Dermal x 91, 13 week Dermal
  Dose (%) Number of Animals Scored Mean MN-PCE/1000 PCE ± SEM Pairwise P
Untreated Control 
 0         
 5 0.530 ± 0.070
Test Chemical Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E Super; OTNE) 
100         
 5 0.450 ± 0.047 0.677

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
2006-03-14 24 hour Female PCE Flow Cytometry Dermal x 91, 13 week Dermal
  Dose (%) Number of Animals Scored Mean Percent PCE ± SEM Pairwise P
Untreated Control 
 0         
 5 0.962 ± 0.060
Test Chemical Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E Super; OTNE) 
100         
 5 1.285 ± 0.344 0.465

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
2006-03-14 24 hour Female NCE Flow Cytometry Dermal x 91, 13 week Dermal
  Dose (%) Number of Animals Scored Mean MN-NCE/1000 NCE ± SEM Pairwise P
Untreated Control 
 0         
 5 0.069 ± 0.016
Test Chemical Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E Super; OTNE) 
100         
 5 0.101 ± 0.019 0.116

Blood

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
2006-03-14 24 hour Female PCE Flow Cytometry Dermal x 91, 13 week Dermal
  Dose (%) Number of Animals Scored Mean MN-PCE/1000 PCE ± SEM Pairwise P
Vehicle Control 95% Ethanol 
 0         
 5 0.580 ± 0.147 0.385
Untreated Control 
 0         
 5 0.530 ± 0.070

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
2006-03-14 24 hour Female PCE Flow Cytometry Dermal x 91, 13 week Dermal
  Dose (%) Number of Animals Scored Mean Percent PCE ± SEM Pairwise P
Vehicle Control 95% Ethanol 
 0         
 5 0.793 ± 0.074 0.112
Untreated Control 
 0         
 5 0.962 ± 0.060

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
2006-03-14 24 hour Female NCE Flow Cytometry Dermal x 91, 13 week Dermal
  Dose (%) Number of Animals Scored Mean MN-NCE/1000 NCE ± SEM Pairwise P
Vehicle Control 95% Ethanol 
 0         
 5 0.077 ± 0.027 0.412
Untreated Control 
 0         
 5 0.069 ± 0.016