Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-02128-0002-0000-7 |
Chemical Name: | Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E Super; OTNE) |
CASRN: | 54464-57-2 |
NTP Study Type: | Genetic Toxicology - Micronucleus |
NTP Study ID: | F35719 |
Strain and Species: | B6C3F1 Mouse |
Study Result: | Male: Equivocal; Female: Positive |
Blood
Start Date | Sample Collection Time | Sex | Cell | Methodology Used | Dosing Regimen | Route | Trend Test P-Value |
---|---|---|---|---|---|---|---|
2006-03-15 | 24 hour | Male | PCE | Flow Cytometry | Dermal x 91, 13 week | Dermal | 0.865 |
Dose (%) | Number of Animals Scored | Mean MN-PCE/1000 PCE ± SEM | Pairwise P | ||||
---|---|---|---|---|---|---|---|
Vehicle Control | 95% Ethanol | 0 |
5 | 2.420 ± 0.160 | |||
Test Chemical | Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E Super; OTNE) | 6.25 |
5 | 2.550 ± 0.240 | 0.397 | ||
12.5 |
5 | 2.780 ± 0.300 | 0.471 | ||||
25 |
5 | 2.430 ± 0.200 | 0.501 | ||||
50 |
5 | 2.240 ± 0.140 | 0.518 |
Start Date | Sample Collection Time | Sex | Cell | Methodology Used | Dosing Regimen | Route | Trend Test P-Value |
---|---|---|---|---|---|---|---|
2006-03-15 | 24 hour | Male | PCE | Flow Cytometry | Dermal x 91, 13 week | Dermal | 0.851 |
Dose (%) | Number of Animals Scored | Mean Percent PCE ± SEM | Pairwise P | ||||
---|---|---|---|---|---|---|---|
Vehicle Control | 95% Ethanol | 0 |
5 | 1.455 ± 0.079 | |||
Test Chemical | Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E Super; OTNE) | 6.25 |
5 | 1.524 ± 0.120 | 0.620 | ||
12.5 |
5 | 1.583 ± 0.080 | 0.651 | ||||
25 |
5 | 1.518 ± 0.042 | 0.695 | ||||
50 |
5 | 1.466 ± 0.054 | 0.717 |
Start Date | Sample Collection Time | Sex | Cell | Methodology Used | Dosing Regimen | Route | Trend Test P-Value |
---|---|---|---|---|---|---|---|
2006-03-15 | 24 hour | Male | NCE | Flow Cytometry | Dermal x 91, 13 week | Dermal | 0.442 |
Dose (%) | Number of Animals Scored | Mean MN-NCE/1000 NCE ± SEM | Pairwise P | ||||
---|---|---|---|---|---|---|---|
Vehicle Control | 95% Ethanol | 0 |
5 | 1.470 ± 0.020 | |||
Test Chemical | Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E Super; OTNE) | 6.25 |
5 | 1.480 ± 0.040 | 0.703 | ||
12.5 |
5 | 1.430 ± 0.040 | 0.787 | ||||
25 |
5 | 1.390 ± 0.050 | 0.820 | ||||
50 |
5 | 1.490 ± 0.020 | 0.477 |
Blood
Start Date | Sample Collection Time | Sex | Cell | Methodology Used | Dosing Regimen | Route | Trend Test P-Value |
---|---|---|---|---|---|---|---|
2006-03-15 | 24 hour | Male | PCE | Flow Cytometry | Dermal x 91, 13 week | Dermal |
Dose (%) | Number of Animals Scored | Mean MN-PCE/1000 PCE ± SEM | Pairwise P | ||||
---|---|---|---|---|---|---|---|
Untreated Control | 0 |
5 | 2.660 ± 0.140 | ||||
Test Chemical | Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E Super; OTNE) | 100 |
5 | 2.290 ± 0.150 | 0.805 |
Start Date | Sample Collection Time | Sex | Cell | Methodology Used | Dosing Regimen | Route | Trend Test P-Value |
---|---|---|---|---|---|---|---|
2006-03-15 | 24 hour | Male | PCE | Flow Cytometry | Dermal x 91, 13 week | Dermal |
Dose (%) | Number of Animals Scored | Mean Percent PCE ± SEM | Pairwise P | ||||
---|---|---|---|---|---|---|---|
Untreated Control | 0 |
5 | 1.599 ± 0.059 | ||||
Test Chemical | Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E Super; OTNE) | 100 |
5 | 2.000 ± 0.196 | 0.066 |
Start Date | Sample Collection Time | Sex | Cell | Methodology Used | Dosing Regimen | Route | Trend Test P-Value |
---|---|---|---|---|---|---|---|
2006-03-15 | 24 hour | Male | NCE | Flow Cytometry | Dermal x 91, 13 week | Dermal |
Dose (%) | Number of Animals Scored | Mean MN-NCE/1000 NCE ± SEM | Pairwise P | ||||
---|---|---|---|---|---|---|---|
Untreated Control | 0 |
5 | 1.450 ± 0.020 | ||||
Test Chemical | Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E Super; OTNE) | 100 |
5 | 1.590 ± 0.030 | 0.001 |
Blood
Start Date | Sample Collection Time | Sex | Cell | Methodology Used | Dosing Regimen | Route | Trend Test P-Value |
---|---|---|---|---|---|---|---|
2006-03-15 | 24 hour | Male | PCE | Flow Cytometry | Dermal x 91, 13 week | Dermal |
Dose (%) | Number of Animals Scored | Mean MN-PCE/1000 PCE ± SEM | Pairwise P | ||||
---|---|---|---|---|---|---|---|
Vehicle Control | 95% Ethanol | 0 |
5 | 2.420 ± 0.160 | 0.707 | ||
Untreated Control | 0 |
5 | 2.660 ± 0.140 |
Start Date | Sample Collection Time | Sex | Cell | Methodology Used | Dosing Regimen | Route | Trend Test P-Value |
---|---|---|---|---|---|---|---|
2006-03-15 | 24 hour | Male | PCE | Flow Cytometry | Dermal x 91, 13 week | Dermal |
Dose (%) | Number of Animals Scored | Mean Percent PCE ± SEM | Pairwise P | ||||
---|---|---|---|---|---|---|---|
Vehicle Control | 95% Ethanol | 0 |
5 | 1.455 ± 0.079 | 0.190 | ||
Untreated Control | 0 |
5 | 1.599 ± 0.059 |
Start Date | Sample Collection Time | Sex | Cell | Methodology Used | Dosing Regimen | Route | Trend Test P-Value |
---|---|---|---|---|---|---|---|
2006-03-15 | 24 hour | Male | NCE | Flow Cytometry | Dermal x 91, 13 week | Dermal |
Dose (%) | Number of Animals Scored | Mean MN-NCE/1000 NCE ± SEM | Pairwise P | ||||
---|---|---|---|---|---|---|---|
Vehicle Control | 95% Ethanol | 0 |
5 | 1.470 ± 0.020 | 0.235 | ||
Untreated Control | 0 |
5 | 1.450 ± 0.020 |
Blood
Start Date | Sample Collection Time | Sex | Cell | Methodology Used | Dosing Regimen | Route | Trend Test P-Value |
---|---|---|---|---|---|---|---|
2006-03-16 | 24 hour | Female | PCE | Flow Cytometry | Dermal x 91, 13 week | Dermal | 0.856 |
Dose (%) | Number of Animals Scored | Mean MN-PCE/1000 PCE ± SEM | Pairwise P | ||||
---|---|---|---|---|---|---|---|
Vehicle Control | 95% Ethanol | 0 |
5 | 2.130 ± 0.120 | |||
Test Chemical | Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E Super; OTNE) | 6.25 |
5 | 1.760 ± 0.100 | 0.877 | ||
12.5 |
5 | 2.150 ± 0.050 | 0.887 | ||||
25 |
5 | 1.950 ± 0.140 | 0.912 | ||||
50 |
5 | 1.850 ± 0.120 | 0.924 |
Start Date | Sample Collection Time | Sex | Cell | Methodology Used | Dosing Regimen | Route | Trend Test P-Value |
---|---|---|---|---|---|---|---|
2006-03-16 | 24 hour | Female | PCE | Flow Cytometry | Dermal x 91, 13 week | Dermal | 0.050 |
Dose (%) | Number of Animals Scored | Mean Percent PCE ± SEM | Pairwise P | ||||
---|---|---|---|---|---|---|---|
Vehicle Control | 95% Ethanol | 0 |
5 | 1.522 ± 0.116 | |||
Test Chemical | Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E Super; OTNE) | 6.25 |
5 | 1.510 ± 0.092 | 1.000 | ||
12.5 |
5 | 2.060 ± 0.134 | 0.053 | ||||
25 |
5 | 1.842 ± 0.207 | 0.056 | ||||
50 |
5 | 1.961 ± 0.140 | 0.045 |
Start Date | Sample Collection Time | Sex | Cell | Methodology Used | Dosing Regimen | Route | Trend Test P-Value |
---|---|---|---|---|---|---|---|
2006-03-16 | 24 hour | Female | NCE | Flow Cytometry | Dermal x 91, 13 week | Dermal | <0.001 |
Dose (%) | Number of Animals Scored | Mean MN-NCE/1000 NCE ± SEM | Pairwise P | ||||
---|---|---|---|---|---|---|---|
Vehicle Control | 95% Ethanol | 0 |
5 | 1.010 ± 0.020 | |||
Test Chemical | Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E Super; OTNE) | 6.25 |
5 | 1.010 ± 0.020 | 0.472 | ||
12.5 |
5 | 1.070 ± 0.040 | 0.064 | ||||
25 |
5 | 1.080 ± 0.020 | 0.039 | ||||
50 |
5 | 1.150 ± 0.010 | 0.001 |
Blood
Start Date | Sample Collection Time | Sex | Cell | Methodology Used | Dosing Regimen | Route | Trend Test P-Value |
---|---|---|---|---|---|---|---|
2006-03-16 | 24 hour | Female | PCE | Flow Cytometry | Dermal x 91, 13 week | Dermal |
Dose (%) | Number of Animals Scored | Mean MN-PCE/1000 PCE ± SEM | Pairwise P | ||||
---|---|---|---|---|---|---|---|
Untreated Control | 0 |
5 | 1.980 ± 0.140 | ||||
Test Chemical | Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E Super; OTNE) | 100 |
5 | 2.880 ± 0.230 | 0.005 |
Start Date | Sample Collection Time | Sex | Cell | Methodology Used | Dosing Regimen | Route | Trend Test P-Value |
---|---|---|---|---|---|---|---|
2006-03-16 | 24 hour | Female | PCE | Flow Cytometry | Dermal x 91, 13 week | Dermal |
Dose (%) | Number of Animals Scored | Mean Percent PCE ± SEM | Pairwise P | ||||
---|---|---|---|---|---|---|---|
Untreated Control | 0 |
5 | 1.075 ± 0.149 | ||||
Test Chemical | Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E Super; OTNE) | 100 |
5 | 1.893 ± 0.246 | 0.031 |
Start Date | Sample Collection Time | Sex | Cell | Methodology Used | Dosing Regimen | Route | Trend Test P-Value |
---|---|---|---|---|---|---|---|
2006-03-16 | 24 hour | Female | NCE | Flow Cytometry | Dermal x 91, 13 week | Dermal |
Dose (%) | Number of Animals Scored | Mean MN-NCE/1000 NCE ± SEM | Pairwise P | ||||
---|---|---|---|---|---|---|---|
Untreated Control | 0 |
5 | 1.030 ± 0.040 | ||||
Test Chemical | Ethanone, 1-(1,2,3,4,5,6,7,8-Octahydro-2,3,8,8-Tetramethyl-2-Naphthalenyl)- (Iso-E Super; OTNE) | 100 |
5 | 1.270 ± 0.010 | <0.001 |
Blood
Start Date | Sample Collection Time | Sex | Cell | Methodology Used | Dosing Regimen | Route | Trend Test P-Value |
---|---|---|---|---|---|---|---|
2006-03-16 | 24 hour | Female | PCE | Flow Cytometry | Dermal x 91, 13 week | Dermal |
Dose (%) | Number of Animals Scored | Mean MN-PCE/1000 PCE ± SEM | Pairwise P | ||||
---|---|---|---|---|---|---|---|
Vehicle Control | 95% Ethanol | 0 |
5 | 2.130 ± 0.120 | 0.230 | ||
Untreated Control | 0 |
5 | 1.980 ± 0.140 |
Start Date | Sample Collection Time | Sex | Cell | Methodology Used | Dosing Regimen | Route | Trend Test P-Value |
---|---|---|---|---|---|---|---|
2006-03-16 | 24 hour | Female | PCE | Flow Cytometry | Dermal x 91, 13 week | Dermal |
Dose (%) | Number of Animals Scored | Mean Percent PCE ± SEM | Pairwise P | ||||
---|---|---|---|---|---|---|---|
Vehicle Control | 95% Ethanol | 0 |
5 | 1.522 ± 0.116 | 0.048 | ||
Untreated Control | 0 |
5 | 1.075 ± 0.149 |
Start Date | Sample Collection Time | Sex | Cell | Methodology Used | Dosing Regimen | Route | Trend Test P-Value |
---|---|---|---|---|---|---|---|
2006-03-16 | 24 hour | Female | NCE | Flow Cytometry | Dermal x 91, 13 week | Dermal |
Dose (%) | Number of Animals Scored | Mean MN-NCE/1000 NCE ± SEM | Pairwise P | ||||
---|---|---|---|---|---|---|---|
Vehicle Control | 95% Ethanol | 0 |
5 | 1.010 ± 0.020 | 0.581 | ||
Untreated Control | 0 |
5 | 1.030 ± 0.040 |