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Study Information
Study Attribute Value
CEBS Accession Number: 002-02303-0003-0000-3
Chemical Name: Isobutene
CASRN: 115-11-7
NTP Study Type: Genetic Toxicology - Micronucleus
NTP Study ID: A91962
Strain and Species: B6C3F1 Mouse
Study Result: Male: Negative; Female: Negative

Blood

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
1992-01-21 24 hour Male NCE Slide Scoring Inhalation x 67, 92 day Inhalation 0.086
  Dose (ppm) Number of Animals Scored Mean MN-NCE/1000 NCE ± SEM Pairwise P
Vehicle Control Air 
 0         
 5 1.100 ± 0.370
Test Chemical Isobutene 
500         
 5 1.400 ± 0.330 0.274 
1000         
 5 1.700 ± 0.120 0.128 
2000         
 5 1.700 ± 0.200 0.128 
4000         
 5 1.600 ± 0.330 0.168 
8000         
 5 2.000 ± 0.470 0.053

Blood

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
1992-01-22 24 hour Female NCE Slide Scoring Inhalation x 67, 92 day Inhalation 0.541
  Dose (ppm) Number of Animals Scored Mean MN-NCE/1000 NCE ± SEM Pairwise P
Vehicle Control Air 
 0         
 5 0.800 ± 0.200
Test Chemical Isobutene 
500         
 5 1.000 ± 0.320 0.319 
1000         
 5 1.100 ± 0.290 0.246 
2000         
 5 0.600 ± 0.100 0.704 
4000         
 5 1.200 ± 0.250 0.185 
8000         
 5 0.800 ± 0.250 0.500