COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-02644-0006-0000-4
Chemical Name: Pentachlorophenol, Dowicide EC-7
CASRN: 87-86-5
NTP Study Type: Genetic Toxicology - Micronucleus
NTP Study ID: A84354
Strain and Species: Fischer 344 Rat
Study Result: Male: Negative

Bone Marrow

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
1993-08-17 24 hour Male PCE Slide Scoring Gavage x 3, 72 hour Gavage 0.062
  Dose (mg/kg) Number of Animals Scored Mean MN-PCE/1000 PCE ± SEM Pairwise P
Vehicle Control Corn Oil 
 0         
 5 0.800 ± 0.340
Test Chemical Pentachlorophenol, Dowicide EC-7 
25         
 4 0.750 ± 0.320 0.548 
50         
 5 1.500 ± 0.350 0.072 
75         
 0.000 ± 0.000
Positive Control Cyclophosphamide 
25         
 5 13.700 ± 3.850 Value less than 0.0001

Start Date Sample Collection Time Sex Cell Methodology Used Dosing Regimen Route Trend Test P-Value
1993-08-17 24 hour Male PCE Slide Scoring Gavage x 3, 72 hour Gavage
  Dose (mg/kg) Number of Animals Scored Mean Percent PCE ± SEM Pairwise P
Vehicle Control Corn Oil 
 0         
 5 39.800 ± 3.260
Test Chemical Pentachlorophenol, Dowicide EC-7 
25         
 4 25.380 ± 4.680 
50         
 5 30.100 ± 4.650 
75         
 0.000 ± 0.000
Positive Control Cyclophosphamide 
25         
 5 11.800 ± 3.340