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Study Information
Study Attribute Value
CEBS Accession Number: 002-02945-0001-0000-3
Chemical Name: Trichloroethylene
CASRN: 79-01-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 365766_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
No Activation  2  Weakly Positive 
Induced Rat Liver S9  1_S9  Weakly Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 03/31/1982    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1022 456 0.446 9.12 26.0 0.000
Test Chemical Trichloroethylene 
17.9       
 50 1011 403 0.399 8.06 26.0 -10.661 
49.7       
 50 1025 466 0.455 9.32 26.0 1.894 
149         
 50 1015 478 0.471 9.56 26.0 5.547 
497         
 50 1010 443 0.439 8.86 26.0 -1.697
Positive Control Mitomycin-C 
 0.005     
 50 1026 1527 1.488 30.54 26.0 233.563
Trend: 0.817        
Probability: 0.207        

Trial #: 2    Activation: No Activation    Date: 04/26/1982    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1031 380 0.369 7.60 25.5 0.000
Test Chemical Trichloroethylene 
499         
 50 1017 383 0.377 7.66 25.5 2.177 
596         
 50 1030 410 0.398 8.20 25.5 7.999 
700         
 50 1016 453 0.446 9.06 30.0 20.971 
801         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.005     
 25 554 511 0.922 20.44 25.5 150.257
Trend: 2.869        
Probability: 0.002        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 03/31/1982    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1031 409 0.397 8.18 27.0 0.000
Test Chemical Trichloroethylene 
49.7       
 50 1029 405 0.394 8.10 27.0 -0.786 
149         
 50 1014 444 0.438 8.88 27.0 10.377 
497         
 50 1048 463 0.442 9.26 27.0 11.367 
1490         
 0 0 0 0.000 0.00 0.0 N/A 
4970         
 0 0 0 0.000 0.00 0.0 N/A 
14900         
 50 1019 526 0.516 10.52 27.0 30.121
Positive Control Cyclophosphamide 
1.5       
 50 1037 1525 1.471 30.50 27.0 270.703
Trend: 4.671        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 04/26/1982    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1032 418 0.405 8.36 25.5 0.000
Test Chemical Trichloroethylene 
401         
 50 1020 504 0.494 10.08 25.5 21.993 
499         
 50 1032 504 0.488 10.08 25.5 20.574 
596         
 50 1034 475 0.459 9.50 25.5 13.417
Positive Control Cyclophosphamide 
1.5       
 50 1047 1024 0.978 20.48 25.5 141.466
Trend: 1.706        
Probability: 0.044