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Study Information
Study Attribute Value
CEBS Accession Number: 002-02997-0001-0000-0
Chemical Name: Vat brown 1
CASRN: 2475-33-4
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 914705_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 05/12/1988    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1048 375 0.358 7.50 26.0 0.000
Test Chemical Vat brown 1 
16         
 50 1007 381 0.378 7.62 26.0 5.737 
50         
 50 1008 403 0.400 8.06 26.0 11.731 
160         
 50 1006 350 0.348 7.00 26.0 -2.770 
500         
 50 1006 377 0.375 7.54 26.0 4.731
Positive Control Mitomycin-C 
 0.0E-4    
 50 1048 502 0.479 10.04 26.0 33.867
Mitomycin-C 
 0.005     
 10 206 239 1.160 23.90 26.0 224.236
Trend: 0.069        
Probability: 0.473        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 05/12/1988    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1044 438 0.420 8.76 26.0 0.000
Test Chemical Vat brown 1 
16         
 50 1045 410 0.392 8.20 26.0 -6.482 
50         
 50 1045 433 0.414 8.66 26.0 -1.236 
160         
 50 1046 459 0.439 9.18 26.0 4.594 
500         
 50 1030 461 0.448 9.22 26.0 6.682
Positive Control Cyclophosphamide 
 0.1       
 50 1043 530 0.508 10.60 26.0 21.121
Cyclophosphamide 
 0.6       
 10 207 170 0.821 17.00 26.0 95.751
Trend: 1.608        
Probability: 0.054