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Study Information
Study Attribute Value
CEBS Accession Number: 002-03013-0001-0000-0
Chemical Name: Zearalenone
CASRN: 17924-92-4
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 679562_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1   
No Activation  2  Positive 
Induced Rat Liver S9  1_S9   
Induced Rat Liver S9  2_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 09/22/1982    Trial Call:   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1047 464 0.443 9.28 25.8 0.000
Test Chemical Zearalenone 
5         
 25 1004 440 0.438 17.60 25.8 -1.111 
16.7       
 0 0 0 0.000 0.00 34.8 N/A 
50         
 0 0 0 0.000 0.00 34.8 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1053 672 0.638 13.44 25.8 44.002
Mitomycin-C 
 0.01      
 5 102 297 2.912 59.40 25.8 557.030
Trend: -0.160        
Probability: 0.564        

Trial #: 2    Activation: No Activation    Date: 09/29/1982    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1049 488 0.465 9.76 25.8 0.000
Test Chemical Zearalenone 
10         
 25 1003 372 0.371 14.88 25.8 -20.274 
12.5       
 25 1018 643 0.632 25.72 35.8 35.775 
15         
 25 996 634 0.637 25.36 35.8 36.831 
17.5       
 0 0 0 0.000 0.00 35.8 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1048 675 0.644 13.50 25.8 38.452
Mitomycin-C 
 0.01      
 5 105 249 2.371 49.80 25.8 409.760
Trend: 7.557        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 09/22/1982    Trial Call:   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1040 440 0.423 8.80 25.8 0.000
Test Chemical Zearalenone 
50         
 50 1041 465 0.447 9.30 25.8 5.580
Positive Control Cyclophosphamide 
 0.35      
 50 1037 684 0.660 13.68 25.8 55.904
Cyclophosphamide 
2         
 5 107 174 1.626 34.80 25.8 284.367
Trend: 0.000        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 09/29/1982    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1042 445 0.427 8.90 25.8 0.000
Test Chemical Zearalenone 
10         
 50 1052 499 0.474 9.98 25.8 11.069 
20         
 50 1044 513 0.491 10.26 25.8 15.060 
40         
 50 1043 504 0.483 10.08 25.8 13.150 
60         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.35      
 50 1049 705 0.672 14.10 25.8 57.370
Cyclophosphamide 
2         
 5 106 161 1.519 32.20 25.8 255.654
Trend: 1.910        
Probability: 0.028