Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-03018-0002-0000-6 |
Chemical Name: | Ziram |
CASRN: | 137-30-4 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 054163_CA |
Study Result: | Positive |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Positive |
Induced Rat Liver S9 | 1_S9 | Positive |
No Activation | 2 | Positive |
Dose µg/mL |
Total Cells Examined |
Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs |
Abs Per Cell |
% Cells With Abs |
No. of Abs. |
Abs Per Cell |
% Cells With Abs |
No. of Abs. |
Abs Per Cell |
% Cells With Abs |
No. of Abs. |
Abs Per Cell |
% Cells With Abs |
||||
Vehicle Control: | Dimethyl Sulfoxide | 0 |
200 | 1 | 0.005 | 1.0 | 0 | 0.000 | 0.0 | 1 | 0.005 | 1.0 | 0 | 0.000 | 0.0 |
Test Chemical: | Ziram | 0.025 |
200 | 17 | 0.085 | 7.0 | 3 | 0.015 | 1.0 | 14 | 0.070 | 6.0 | 0 | 0.000 | 0.0 |
0.05 |
200 | 36 | 0.180 | 12.0 | 8 | 0.040 | 3.0 | 28 | 0.140 | 10.0 | 0 | 0.000 | 0.0 | ||
0.1 |
157 | 26 | 0.166 | 10.0 | 6 | 0.038 | 4.0 | 19 | 0.121 | 7.0 | 1 | 0.006 | 1.0 | ||
0.15 |
0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 0.063 |
200 | 143 | 0.715 | 42.0 | 66 | 0.330 | 26.0 | 57 | 0.285 | 24.0 | 20 | 0.100 | 2.0 |
Mitomycin-C | 0.125 |
50 | 85 | 1.700 | 66.0 | 33 | 0.660 | 44.0 | 32 | 0.640 | 40.0 | 20 | 0.400 | 2.0 | |
Trend: | 3.812 | 3.105 | 2.943 | ||||||||||||
Probability: | 0.000 | 0.001 | 0.002 |
Dose µg/mL |
Total Cells Examined |
Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs |
Abs Per Cell |
% Cells With Abs |
No. of Abs. |
Abs Per Cell |
% Cells With Abs |
No. of Abs. |
Abs Per Cell |
% Cells With Abs |
No. of Abs. |
Abs Per Cell |
% Cells With Abs |
||||
Vehicle Control: | Dimethyl Sulfoxide | 0 |
200 | 2 | 0.010 | 1.0 | 1 | 0.005 | 1.0 | 1 | 0.005 | 1.0 | 0 | 0.000 | 0.0 |
Test Chemical: | Ziram | 1.5 |
200 | 26 | 0.130 | 10.0 | 10 | 0.050 | 5.0 | 16 | 0.080 | 7.0 | 0 | 0.000 | 0.0 |
1.75 |
200 | 42 | 0.210 | 16.0 | 19 | 0.095 | 9.0 | 23 | 0.115 | 10.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 5 |
200 | 66 | 0.330 | 29.0 | 23 | 0.115 | 11.0 | 43 | 0.215 | 21.0 | 0 | 0.000 | 0.0 |
Cyclophosphamide | 10 |
50 | 74 | 1.480 | 84.0 | 39 | 0.780 | 54.0 | 35 | 0.700 | 56.0 | 0 | 0.000 | 0.0 | |
Trend: | 4.237 | 3.179 | 2.917 | ||||||||||||
Probability: | 0.000 | 0.001 | 0.002 |
Dose µg/mL |
Total Cells Examined |
Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs |
Abs Per Cell |
% Cells With Abs |
No. of Abs. |
Abs Per Cell |
% Cells With Abs |
No. of Abs. |
Abs Per Cell |
% Cells With Abs |
No. of Abs. |
Abs Per Cell |
% Cells With Abs |
||||
Vehicle Control: | Dimethyl Sulfoxide | 0 |
200 | 4 | 0.020 | 2.0 | 1 | 0.005 | 1.0 | 3 | 0.015 | 2.0 | 0 | 0.000 | 0.0 |
Test Chemical: | Ziram | 0.01 |
200 | 9 | 0.045 | 3.0 | 1 | 0.005 | 1.0 | 8 | 0.040 | 2.0 | 0 | 0.000 | 0.0 |
0.025 |
200 | 82 | 0.410 | 24.0 | 20 | 0.100 | 10.0 | 52 | 0.260 | 19.0 | 10 | 0.050 | 1.0 | ||
0.05 |
200 | 35 | 0.175 | 11.0 | 1 | 0.005 | 1.0 | 23 | 0.115 | 10.0 | 11 | 0.055 | 2.0 | ||
0.1 |
48 | 15 | 0.313 | 8.0 | 1 | 0.021 | 2.0 | 4 | 0.083 | 6.0 | 10 | 0.208 | 1.0 | ||
0.15 |
0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 0.063 |
200 | 150 | 0.750 | 44.0 | 69 | 0.345 | 27.0 | 80 | 0.400 | 29.0 | 1 | 0.005 | 1.0 |
Mitomycin-C | 0.125 |
50 | 88 | 1.760 | 80.0 | 42 | 0.840 | 48.0 | 45 | 0.900 | 58.0 | 1 | 0.020 | 1.0 | |
Trend: | 4.623 | 1.474 | 4.238 | ||||||||||||
Probability: | 0.000 | 0.070 | 0.000 |