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Study Information
Study Attribute Value
CEBS Accession Number: 002-02769-0019-0000-6
Chemical Name: Reserpine
CASRN: 50-55-5
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 013797_CA
Study Result: Positive


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
05/14/1989 Bone Marrow 36 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 36 hour Positive

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
25         
 11889 50 16 7 0 0 0 0 0 23 0.46 0.32 26.00 22.00
    11902 50 14 2 0 0 0 0 0 16 0.32 0.28 24.00 22.00
    11926 50 5 3 0 0 0 0 0 8 0.16 0.10 12.00 8.00
    11939 50 10 2 0 0 0 0 0 12 0.24 0.20 16.00 16.00
    11942 50 18 5 1 0 0 0 0 24 0.48 0.38 28.00 20.00
    11966 50 17 1 1 0 0 0 0 19 0.38 0.36 16.00 14.00
    11972 50 13 3 0 0 0 0 0 16 0.32 0.26 12.00 8.00
    11990 50 11 2 0 0 0 0 0 13 0.26 0.22 8.00 4.00
Average         13.0 3.1 0.3 0.0 0.0 0.0 0.0 16.4 0.33 0.27 17.75 14.25
± SEM                         0.04 0.03 2.60 2.46
 
Test Chemical Reserpine 
50         
 11961 50 5 2 0 0 0 0 0 7 0.14 0.10 8.00 6.00
    11963 50 3 3 0 0 0 0 0 6 0.12 0.06 8.00 6.00
    11964 50 2 3 0 0 0 0 0 5 0.10 0.04 8.00 2.00
    11965 50 4 1 1 0 0 0 0 6 0.12 0.10 10.00 8.00
    11973 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    11978 50 3 1 1 0 0 0 0 5 0.10 0.08 10.00 8.00
    11979 50 1 2 1 1 0 0 0 5 0.10 0.04 8.00 4.00
    11995 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
Average         2.8 1.8 0.4 0.1 0.0 0.0 0.0 5.0 0.10 0.06 8.00 5.25
± SEM                         0.01 0.01 0.53 0.84
 
Test Chemical Reserpine 
100         
 11968 50 4 1 0 0 0 0 0 5 0.10 0.08 8.00 8.00
    11975 50 1 0 0 0 0 0 1 2 0.04 0.04 2.00 2.00
    11976 50 4 1 0 0 0 0 0 5 0.10 0.08 8.00 8.00
    11983 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    11989 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    11993 50 5 2 0 0 0 0 0 7 0.14 0.10 12.00 8.00
    11994 50 4 1 0 1 0 0 1 7 0.14 0.10 14.00 10.00
Average         2.9 0.9 0.0 0.1 0.0 0.0 0.3 4.1 0.08 0.06 7.14 5.71
± SEM                         0.02 0.01 1.79 1.34
 
Test Chemical Reserpine 
200         
 11969 50 1 2 0 1 0 0 0 4 0.08 0.02 6.00 2.00
    11974 50 4 1 0 0 0 0 0 5 0.10 0.08 8.00 6.00
    11981 50 4 1 2 0 0 0 0 7 0.14 0.12 10.00 8.00
    11984 50 1 1 2 0 0 0 0 4 0.08 0.06 6.00 6.00
    11985 50 0 1 0 0 0 0 1 2 0.04 0.02 2.00 0.00
    11986 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    11988 50 2 1 1 0 0 0 0 4 0.08 0.06 8.00 6.00
    11992 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         1.6 1.0 0.6 0.1 0.0 0.0 0.1 3.5 0.07 0.05 5.50 3.75
± SEM                         0.02 0.01 1.18 1.10
 
Vehicle Control No Stressor 
 0         
 11894 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    11905 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    11924 50 4 4 0 0 0 0 0 8 0.16 0.08 14.00 6.00
    11935 50 0 3 0 0 0 0 0 3 0.06 0.00 6.00 0.00
    11941 50 1 3 0 0 0 0 0 4 0.08 0.02 6.00 2.00
    11944 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    11970 50 0 1 0 0 0 0 0 1 0.02 0.00 4.00 2.00
    11982 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
Average         1.0 2.0 0.0 0.0 0.0 0.0 0.0 3.0 0.06 0.02 5.75 2.00
± SEM                         0.02 0.01 1.28 0.65
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation