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Study Information
Study Attribute Value
CEBS Accession Number: 002-02769-0019-0000-6
Chemical Name: Reserpine
CASRN: 50-55-5
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 013797_CA
Study Result: Positive


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
06/01/1989 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Positive

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
100         
 12045 50 10 21 0 0 0 0 0 31 0.62 0.20 34.00 18.00
    12062 50 7 7 0 0 0 0 0 14 0.28 0.14 16.00 12.00
    12064 50 9 2 0 0 0 0 0 11 0.22 0.18 16.00 14.00
    12068 50 6 4 0 0 0 0 0 10 0.20 0.12 16.00 12.00
    12077 50 15 16 0 0 0 0 2 33 0.66 0.34 38.00 26.00
    12105 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    12111 50 13 7 0 0 0 0 0 20 0.40 0.26 20.00 8.00
    12120 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
Average         7.6 7.5 0.0 0.0 0.0 0.0 0.3 15.4 0.31 0.16 18.50 11.50
± SEM                         0.08 0.04 4.37 2.97
 
Test Chemical Reserpine 
50         
 12085 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12089 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12092 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12099 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    12106 50 0 0 0 0 0 0 1 1 0.02 0.02 0.00 0.00
    12114 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12119 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12121 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.1 0.0 0.0 0.0 0.0 0.0 0.1 0.3 0.01 0.01 0.25 0.25
± SEM                         0.00 0.00 0.25 0.25
 
Test Chemical Reserpine 
100         
 12087 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12090 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    12093 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    12094 50 0 4 0 0 0 0 0 4 0.08 0.00 6.00 0.00
    12113 50 0 3 0 0 0 0 0 3 0.06 0.00 4.00 0.00
    12116 50 0 2 0 0 0 0 0 2 0.04 0.00 2.00 0.00
    12117 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    12122 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.3 1.5 0.0 0.0 0.0 0.0 0.0 1.8 0.04 0.01 2.75 0.50
± SEM                         0.01 0.00 0.75 0.33
 
Test Chemical Reserpine 
200         
 12091 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    12096 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12098 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12104 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    12107 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    12112 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    12123 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
Average         0.4 0.6 0.0 0.0 0.0 0.0 0.0 1.0 0.02 0.01 2.00 0.86
± SEM                         0.01 0.00 0.62 0.40
 
Vehicle Control No Stressor 
 0         
 12056 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    12063 50 1 6 0 0 0 0 0 7 0.14 0.02 10.00 2.00
    12074 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12080 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    12083 50 3 2 0 0 0 0 1 6 0.12 0.08 8.00 6.00
    12095 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    12103 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    12109 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.6 1.4 0.0 0.0 0.0 0.0 0.1 2.1 0.04 0.02 3.25 1.25
± SEM                         0.02 0.01 1.36 0.75
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation