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Study Information
Study Attribute Value
CEBS Accession Number: 002-02769-0019-0000-6
Chemical Name: Reserpine
CASRN: 50-55-5
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 013797_CA
Study Result: Positive


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
09/27/1989 Bone Marrow 36 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 36 hour Positive

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
25         
 13035 50 9 4 0 0 0 0 1 14 0.28 0.20 18.00 14.00
    13042 50 6 1 0 0 0 0 1 8 0.16 0.14 12.00 10.00
    13046 50 4 4 0 0 0 1 1 10 0.20 0.12 16.00 10.00
    13051 50 7 2 0 0 0 1 0 10 0.20 0.16 12.00 10.00
    13056 50 5 2 0 0 0 0 1 8 0.16 0.12 12.00 8.00
    13063 50 12 4 0 0 0 0 0 16 0.32 0.24 22.00 16.00
    13071 50 18 5 1 0 0 0 0 24 0.48 0.38 24.00 18.00
Average         8.7 3.1 0.1 0.0 0.0 0.3 0.6 12.9 0.26 0.19 16.57 12.29
± SEM                         0.04 0.04 1.89 1.41
 
Test Chemical Reserpine 
50         
 13036 50 6 2 0 1 0 0 0 9 0.18 0.12 12.00 8.00
    13048 50 3 2 0 0 0 0 0 5 0.10 0.06 10.00 6.00
    13050 50 0 2 0 0 0 0 0 2 0.04 0.00 6.00 2.00
    13054 50 3 2 0 0 0 0 0 5 0.10 0.06 10.00 6.00
    13062 50 4 2 0 1 0 0 0 7 0.14 0.08 14.00 8.00
    13067 50 3 2 0 0 0 0 0 5 0.10 0.06 10.00 6.00
    13070 50 6 6 0 0 0 0 0 12 0.24 0.12 16.00 10.00
    13073 50 6 6 0 0 0 0 0 12 0.24 0.12 20.00 12.00
Average         3.9 3.0 0.0 0.3 0.0 0.0 0.0 7.1 0.14 0.08 12.25 7.25
± SEM                         0.03 0.01 1.53 1.06
 
Test Chemical Reserpine 
100         
 13032 50 3 6 0 1 0 0 1 11 0.22 0.08 16.00 8.00
    13033 50 5 2 0 1 0 0 1 9 0.18 0.12 14.00 10.00
    13038 50 5 1 1 1 0 0 0 8 0.16 0.12 14.00 12.00
    13044 50 1 3 0 0 0 0 0 4 0.08 0.02 8.00 2.00
    13047 50 6 6 0 0 0 0 0 12 0.24 0.12 14.00 10.00
    13053 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    13066 50 5 3 0 0 0 0 1 9 0.18 0.12 14.00 12.00
    13072 50 5 5 0 0 0 0 0 10 0.20 0.10 18.00 10.00
Average         3.9 3.5 0.1 0.4 0.0 0.0 0.4 8.3 0.17 0.09 13.00 8.25
± SEM                         0.02 0.02 1.41 1.44
 
Test Chemical Reserpine 
150         
 13034 50 4 3 0 0 0 0 1 8 0.16 0.10 12.00 8.00
    13040 50 1 3 0 1 0 0 0 5 0.10 0.02 10.00 2.00
    13041 50 6 5 0 1 0 0 1 13 0.26 0.14 20.00 14.00
    13043 50 4 0 0 0 0 0 0 4 0.08 0.08 8.00 8.00
    13055 50 4 3 0 1 0 0 0 8 0.16 0.08 16.00 8.00
    13057 50 4 4 0 1 0 0 1 10 0.20 0.10 14.00 10.00
    13075 50 8 4 0 1 0 0 0 13 0.26 0.16 26.00 16.00
    13076 50 8 4 0 2 0 0 0 14 0.28 0.16 24.00 16.00
Average         4.9 3.3 0.0 0.9 0.0 0.0 0.4 9.4 0.19 0.11 16.25 10.25
± SEM                         0.03 0.02 2.31 1.71
 
Vehicle Control No Stressor 
 0         
 13039 50 1 2 0 1 0 0 1 5 0.10 0.04 6.00 2.00
    13045 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13049 50 0 2 0 0 0 0 1 3 0.06 0.02 4.00 0.00
    13052 0 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13061 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    13064 50 1 3 0 0 0 0 2 6 0.12 0.06 6.00 2.00
    13068 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    13074 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
Average         0.5 1.4 0.0 0.1 0.0 0.0 0.5 2.5 0.05 0.02 4.00 1.14
± SEM                         0.01 0.01 0.82 0.38
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation