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Study Information
Study Attribute Value
CEBS Accession Number: 002-02797-0015-0000-3
Chemical Name: Selenium sulfide
CASRN: 7446-34-6
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 023793_CA
Study Result: Positive


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
03/08/1989 Bone Marrow 36 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 36 hour Positive

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
25         
 11296 50 41 14 0 0 0 0 0 55 1.10 0.82 32.00 24.00
    11314 50 21 6 0 0 0 0 1 28 0.56 0.44 14.00 6.00
    11323 50 61 7 0 0 0 0 1 69 1.38 1.24 32.00 22.00
    11335 50 40 5 0 0 0 0 0 45 0.90 0.80 26.00 20.00
    11338 50 35 7 0 0 0 0 0 42 0.84 0.70 30.00 16.00
    11355 50 5 8 0 0 0 0 0 13 0.26 0.10 20.00 8.00
    11384 50 4 10 0 2 0 0 1 17 0.34 0.10 30.00 10.00
    11387 50 51 4 0 0 0 0 0 55 1.10 1.02 24.00 18.00
Average         32.3 7.6 0.0 0.3 0.0 0.0 0.4 40.5 0.81 0.65 26.00 15.50
± SEM                         0.14 0.15 2.27 2.38
 
Test Chemical Selenium sulfide 
5         
 11332 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    11353 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    11354 50 1 2 0 0 0 0 0 3 0.06 0.02 4.00 2.00
    11356 50 0 3 2 0 0 0 0 5 0.10 0.04 8.00 2.00
    11358 50 2 2 0 0 0 0 0 4 0.08 0.04 8.00 4.00
    11359 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    11360 50 4 3 0 0 0 1 0 8 0.16 0.10 14.00 8.00
    11361 50 2 2 0 0 0 0 0 4 0.08 0.04 8.00 4.00
Average         1.3 2.0 0.3 0.0 0.0 0.1 0.0 3.6 0.07 0.03 6.50 2.75
± SEM                         0.02 0.01 1.35 0.92
 
Test Chemical Selenium sulfide 
10         
 11331 50 8 3 0 1 0 0 1 13 0.26 0.18 22.00 16.00
    11334 50 5 1 0 0 0 0 0 6 0.12 0.10 8.00 6.00
    11336 50 7 2 0 0 0 0 1 10 0.20 0.16 16.00 12.00
    11342 50 2 2 0 0 0 0 1 5 0.10 0.06 8.00 4.00
    11345 50 14 3 0 0 0 0 0 17 0.34 0.28 16.00 10.00
    11346 50 2 3 2 0 0 0 0 7 0.14 0.08 12.00 6.00
    11366 50 4 1 0 0 0 0 0 5 0.10 0.08 10.00 8.00
    11368 50 5 5 0 0 0 0 0 10 0.20 0.10 12.00 6.00
Average         5.9 2.5 0.3 0.1 0.0 0.0 0.4 9.1 0.18 0.13 13.00 8.50
± SEM                         0.03 0.03 1.69 1.40
 
Test Chemical Selenium sulfide 
20         
 11337 50 6 4 0 0 0 0 0 10 0.20 0.12 18.00 10.00
    11341 50 4 5 1 0 0 0 2 12 0.24 0.14 18.00 10.00
    11343 50 13 4 0 0 1 0 0 18 0.36 0.28 28.00 24.00
    11344 50 16 6 0 0 0 0 0 22 0.44 0.32 26.00 14.00
    11349 50 2 3 0 0 0 0 0 5 0.10 0.04 8.00 4.00
    11357 50 9 3 0 1 0 0 0 13 0.26 0.18 18.00 14.00
    11363 50 8 4 1 0 0 0 1 14 0.28 0.20 22.00 18.00
    11365 50 2 4 1 0 0 0 0 7 0.14 0.06 12.00 6.00
Average         7.5 4.1 0.4 0.1 0.1 0.0 0.4 12.6 0.25 0.17 18.75 12.50
± SEM                         0.04 0.03 2.36 2.29
 
Vehicle Control No Stressor 
 0         
 11297 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    11340 50 0 3 0 0 0 0 0 3 0.06 0.00 6.00 0.00
    11351 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    11362 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    11364 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    11367 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    11388 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    11403 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
Average         0.8 1.3 0.0 0.0 0.0 0.0 0.0 2.0 0.04 0.02 4.00 1.50
± SEM                         0.01 0.01 0.65 0.50
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation