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Study Information
Study Attribute Value
CEBS Accession Number: 002-02797-0015-0000-3
Chemical Name: Selenium sulfide
CASRN: 7446-34-6
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 023793_CA
Study Result: Positive


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
03/22/1989 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Positive

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
100         
 11476 50 9 9 0 0 0 0 0 18 0.36 0.18 26.00 14.00
    11488 50 6 7 0 0 0 0 0 13 0.26 0.12 22.00 12.00
    11500 50 6 8 0 0 0 0 0 14 0.28 0.12 22.00 10.00
    11512 50 6 7 0 0 0 0 1 14 0.28 0.14 24.00 12.00
    11524 50 6 13 0 1 0 0 1 21 0.42 0.14 36.00 16.00
    11526 50 7 16 0 1 0 0 0 24 0.48 0.14 40.00 14.00
    11529 50 9 13 0 0 0 0 0 22 0.44 0.18 32.00 16.00
    11541 50 5 7 0 0 0 0 1 13 0.26 0.12 18.00 10.00
Average         6.8 10.0 0.0 0.3 0.0 0.0 0.4 17.4 0.35 0.14 27.50 13.00
± SEM                         0.03 0.01 2.72 0.85
 
Test Chemical Selenium sulfide 
5         
 11471 50 0 4 0 0 0 0 0 4 0.08 0.00 8.00 0.00
    11483 50 4 5 0 0 0 0 0 9 0.18 0.08 12.00 8.00
    11489 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    11492 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    11495 50 3 1 0 0 0 0 0 4 0.08 0.06 6.00 6.00
    11496 50 2 8 0 0 0 0 0 10 0.20 0.04 14.00 4.00
    11502 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    11508 50 3 2 0 0 0 0 0 5 0.10 0.06 10.00 6.00
Average         1.6 2.8 0.0 0.0 0.0 0.0 0.0 4.4 0.09 0.03 7.00 3.25
± SEM                         0.03 0.01 1.73 1.13
 
Test Chemical Selenium sulfide 
10         
 11472 50 1 3 0 0 0 0 0 4 0.08 0.02 8.00 2.00
    11473 50 2 2 0 0 0 0 0 4 0.08 0.04 6.00 4.00
    11474 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    11491 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    11505 50 3 1 0 0 0 0 0 4 0.08 0.06 6.00 6.00
    11507 50 0 2 0 0 0 0 1 3 0.06 0.02 4.00 0.00
    11509 50 1 8 0 0 0 0 0 9 0.18 0.02 14.00 2.00
    11510 50 1 2 0 0 0 0 0 3 0.06 0.02 4.00 2.00
Average         1.0 2.5 0.0 0.0 0.0 0.0 0.1 3.6 0.07 0.02 5.75 2.00
± SEM                         0.02 0.01 1.44 0.76
 
Test Chemical Selenium sulfide 
20         
 11470 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    11475 50 2 3 0 0 0 0 0 5 0.10 0.04 8.00 4.00
    11478 50 2 6 0 0 0 0 0 8 0.16 0.04 14.00 4.00
    11485 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    11487 50 4 4 0 0 0 0 0 8 0.16 0.08 12.00 8.00
    11497 50 3 3 0 0 0 0 1 7 0.14 0.08 12.00 6.00
    11499 50 3 3 0 0 0 0 0 6 0.12 0.06 14.00 8.00
    11503 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
Average         2.1 2.8 0.0 0.0 0.0 0.0 0.1 5.0 0.10 0.05 9.00 4.50
± SEM                         0.02 0.01 1.65 0.98
 
Vehicle Control No Stressor 
 0         
 11479 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    11480 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    11484 50 1 2 0 0 0 0 0 3 0.06 0.02 4.00 2.00
    11498 50 2 4 0 0 0 0 1 7 0.14 0.06 10.00 4.00
    11504 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    11506 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    11528 50 1 6 0 0 0 0 0 7 0.14 0.02 8.00 2.00
    11537 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
Average         0.8 2.0 0.0 0.0 0.0 0.0 0.1 2.9 0.06 0.02 4.25 1.50
± SEM                         0.02 0.01 1.22 0.50
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation