| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-02797-0014-0000-2 |
| Chemical Name: | Selenium sulfide |
| CASRN: | 7446-34-6 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 023793_SCE |
| Study Result: | Positive |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 12/20/1988 | Bone Marrow | 42 | Male | Mouse | B6C3F1 | IP/IJ x 1, 42 hour | Positive |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Corn Oil |
0 |
10765 | 25 | 6.31 | ± | 0.447 |
| 10776 | 25 | 6.22 | ± | 0.595 | |||
| 10792 | 25 | 5.60 | ± | 0.337 | |||
| 10799 | 25 | 5.53 | ± | 0.527 | |||
| Average | 5.92 | ± | 0.203 | ||||
| Test Chemical | Selenium sulfide |
3.75 |
10771 | 25 | 5.76 | ± | 0.483 |
| 10774 | 24 | 3.63 | ± | 0.509 | |||
| 10780 | 25 | 5.18 | ± | 0.615 | |||
| 10783 | 25 | 6.52 | ± | 0.646 | |||
| Average | 5.30 | ± | 0.613 | ||||
| Test Chemical | Selenium sulfide |
7.5 |
10768 | 25 | 7.05 | ± | 0.725 |
| 10777 | 25 | 9.49 | ± | 0.854 | |||
| 10782 | 25 | 7.46 | ± | 0.591 | |||
| 10785 | 25 | 6.08 | ± | 0.608 | |||
| Average | 7.53 | ± | 0.718 | ||||
| Test Chemical | Selenium sulfide |
15 |
10769 | 25 | 8.84 | ± | 0.668 |
| 10772 | 25 | 8.32 | ± | 1.044 | |||
| 10775 | 25 | 7.88 | ± | 0.568 | |||
| 10784 | 25 | 9.21 | ± | 0.662 | |||
| Average | 8.57 | ± | 0.290 | ||||
| Positive Control | Dimethylbenzanthracene |
25 |
10770 | 25 | 17.79 | ± | 1.743 |
| 10779 | 25 | 21.08 | ± | 1.406 | |||
| 10786 | 25 | 18.78 | ± | 1.222 | |||
| 10806 | 25 | 19.06 | ± | 1.871 | |||
| Average | 19.18 | ± | 0.690 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed