| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-02797-0014-0000-2 |
| Chemical Name: | Selenium sulfide |
| CASRN: | 7446-34-6 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 023793_SCE |
| Study Result: | Positive |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 02/15/1989 | Bone Marrow | 23 | Male | Mouse | B6C3F1 | IP/IJ x 1, 23 hour | Negative |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Corn Oil |
0 |
11161 | 25 | 5.45 | ± | 0.344 |
| 11168 | 25 | 3.82 | ± | 0.300 | |||
| 11180 | 25 | 3.86 | ± | 0.378 | |||
| 11195 | 25 | 4.26 | ± | 0.373 | |||
| Average | 4.35 | ± | 0.381 | ||||
| Test Chemical | Selenium sulfide |
3.75 |
11147 | 25 | 4.48 | ± | 0.403 |
| 11155 | 25 | 5.81 | ± | 0.439 | |||
| 11159 | 25 | 4.46 | ± | 0.389 | |||
| 11163 | 25 | 6.97 | ± | 0.604 | |||
| Average | 5.44 | ± | 0.603 | ||||
| Test Chemical | Selenium sulfide |
7.5 |
11149 | 23 | 4.16 | ± | 0.364 |
| 11150 | 24 | 4.66 | ± | 0.296 | |||
| 11158 | 25 | 4.84 | ± | 0.458 | |||
| 11164 | 25 | 5.12 | ± | 0.410 | |||
| Average | 4.71 | ± | 0.201 | ||||
| Test Chemical | Selenium sulfide |
15 |
11148 | 25 | 4.57 | ± | 0.324 |
| 11151 | 25 | 5.26 | ± | 0.412 | |||
| 11165 | 25 | 4.38 | ± | 0.581 | |||
| 11169 | 25 | 4.32 | ± | 0.337 | |||
| Average | 4.63 | ± | 0.216 | ||||
| Positive Control | Dimethylbenzanthracene |
2.5 |
11160 | 25 | 8.75 | ± | 0.803 |
| 11172 | 25 | 7.41 | ± | 0.643 | |||
| 11178 | 25 | 8.07 | ± | 0.813 | |||
| 11201 | 25 | 8.59 | ± | 0.605 | |||
| Average | 8.21 | ± | 0.303 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed