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Study Information
Study Attribute Value
CEBS Accession Number: 002-02235-0010-0000-5
Chemical Name: Hamamelis water (witch hazel)
CASRN: 68916-39-2
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 042552_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
09/23/1992 Bone Marrow 36 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 36 hour Negative

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Mitomycin-C 
1         
 13060 50 8 4 1 0 0 0 0 13 0.26 0.18 20.00 14.00
    13061 50 12 2 0 1 0 0 0 15 0.30 0.24 26.00 22.00
    13062 50 7 1 0 0 0 0 1 9 0.18 0.16 12.00 12.00
    13063 50 1 6 0 0 0 0 0 7 0.14 0.02 12.00 2.00
    13064 50 4 3 0 0 0 0 0 7 0.14 0.08 12.00 8.00
    13065 50 6 2 1 0 0 0 0 9 0.18 0.14 14.00 10.00
    13066 50 1 2 0 0 0 0 0 3 0.06 0.02 6.00 2.00
    13067 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
Average         5.0 2.5 0.3 0.1 0.0 0.0 0.1 8.0 0.16 0.11 13.00 9.00
± SEM                         0.03 0.03 2.65 2.51
 
Test Chemical Hamamelis water (witch hazel) 
1250         
 13020 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    13022 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    13023 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    13024 50 3 0 0 0 0 0 0 3 0.06 0.06 4.00 4.00
    13025 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    13026 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13027 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13028 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.9 0.0 0.0 0.0 0.0 0.0 0.0 0.9 0.02 0.02 1.50 1.50
± SEM                         0.01 0.01 0.50 0.50
 
Test Chemical Hamamelis water (witch hazel) 
2500         
 13030 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13031 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13032 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13033 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    13034 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    13035 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13036 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    13037 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.1 0.3 0.0 0.0 0.0 0.0 0.0 0.4 0.01 0.00 0.75 0.25
± SEM                         0.00 0.00 0.37 0.25
 
Test Chemical Hamamelis water (witch hazel) 
5000         
 13040 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    13041 50 1 0 1 0 0 0 0 2 0.04 0.04 2.00 2.00
    13042 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13043 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13044 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13046 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    13047 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13048 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.4 0.0 0.1 0.0 0.0 0.0 0.0 0.5 0.01 0.01 0.75 0.75
± SEM                         0.01 0.01 0.37 0.37
 
Vehicle Control No Stressor 
 0         
 13050 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    13051 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13052 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    13053 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    13054 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13055 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    13056 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    13057 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
Average         0.4 0.4 0.0 0.0 0.0 0.0 0.0 0.8 0.02 0.01 1.50 0.75
± SEM                         0.01 0.00 0.50 0.37
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation