| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-02235-0009-0000-3 |
| Chemical Name: | Hamamelis water (witch hazel) |
| CASRN: | 68916-39-2 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 042552_SCE |
| Study Result: | Negative |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 05/05/1987 | Bone Marrow | 23 | Male | Mouse | B6C3F1 | IP/IJ x 1, 23 hour | Negative |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Phosphate Buffered Saline |
0 |
5422 | 25 | 4.31 | ± | 0.511 |
| 5423 | 25 | 2.72 | ± | 0.378 | |||
| 5424 | 25 | 2.68 | ± | 0.330 | |||
| 5425 | 25 | 4.77 | ± | 0.544 | |||
| Average | 3.62 | ± | 0.539 | ||||
| Test Chemical | Hamamelis water (witch hazel) |
1250 |
5393 | 25 | 6.45 | ± | 0.814 |
| 5394 | 25 | 3.86 | ± | 0.483 | |||
| 5395 | 25 | 4.13 | ± | 0.553 | |||
| 5396 | 25 | 4.01 | ± | 0.552 | |||
| Average | 4.61 | ± | 0.615 | ||||
| Test Chemical | Hamamelis water (witch hazel) |
2500 |
5397 | 25 | 4.79 | ± | 0.614 |
| 5398 | 25 | 5.79 | ± | 0.537 | |||
| 5399 | 25 | 4.93 | ± | 0.497 | |||
| 5400 | 25 | 7.83 | ± | 0.895 | |||
| Average | 5.84 | ± | 0.701 | ||||
| Test Chemical | Hamamelis water (witch hazel) |
5000 |
5402 | 25 | 4.48 | ± | 0.606 |
| 5403 | 25 | 5.09 | ± | 0.510 | |||
| 5404 | 25 | 5.84 | ± | 0.693 | |||
| 5405 | 25 | 4.49 | ± | 0.469 | |||
| Average | 4.97 | ± | 0.323 | ||||
| Positive Control | Mitomycin-C |
0.5 |
5427 | 25 | 9.62 | ± | 0.918 |
| 5428 | 25 | 10.99 | ± | 0.717 | |||
| 5429 | 25 | 4.37 | ± | 0.510 | |||
| 5430 | 25 | 8.14 | ± | 0.655 | |||
| Average | 8.28 | ± | 1.426 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed