| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-02235-0009-0000-3 |
| Chemical Name: | Hamamelis water (witch hazel) |
| CASRN: | 68916-39-2 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 042552_SCE |
| Study Result: | Negative |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 01/03/1990 | Bone Marrow | 42 | Male | Mouse | B6C3F1 | IP/IJ x 1, 42 hour | Negative |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Phosphate Buffered Saline |
0 |
10635 | 25 | 2.96 | ± | 0.393 |
| 10636 | 25 | 3.08 | ± | 0.310 | |||
| 10637 | 25 | 3.24 | ± | 0.393 | |||
| 10638 | 25 | 4.18 | ± | 0.557 | |||
| Average | 3.37 | ± | 0.277 | ||||
| Test Chemical | Hamamelis water (witch hazel) |
1250 |
10605 | 25 | 4.72 | ± | 0.607 |
| 10606 | 25 | 4.37 | ± | 0.510 | |||
| 10607 | 25 | 5.89 | ± | 0.667 | |||
| 10608 | 25 | 3.60 | ± | 0.311 | |||
| Average | 4.65 | ± | 0.477 | ||||
| Test Chemical | Hamamelis water (witch hazel) |
2500 |
10610 | 25 | 2.81 | ± | 0.306 |
| 10611 | 25 | 3.32 | ± | 0.386 | |||
| 10612 | 25 | 2.69 | ± | 0.364 | |||
| 10613 | 25 | 3.08 | ± | 0.399 | |||
| Average | 2.98 | ± | 0.143 | ||||
| Test Chemical | Hamamelis water (witch hazel) |
5000 |
10615 | 25 | 3.48 | ± | 0.326 |
| 10616 | 25 | 7.73 | ± | 0.840 | |||
| 10617 | 25 | 5.93 | ± | 0.676 | |||
| 10618 | 25 | 3.00 | ± | 0.379 | |||
| Average | 5.04 | ± | 1.103 | ||||
| Positive Control | Mitomycin-C |
0.5 |
10640 | 25 | 8.68 | ± | 0.680 |
| 10641 | 25 | 8.70 | ± | 0.646 | |||
| 10642 | 25 | 7.10 | ± | 0.626 | |||
| 10643 | 25 | 11.92 | ± | 0.728 | |||
| Average | 9.10 | ± | 1.013 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed