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Study Information
Study Attribute Value
CEBS Accession Number: 002-01294-0024-0000-4
Chemical Name: 2-Biphenylamine hydrochloride
CASRN: 2185-92-4
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 047126_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
12/13/1984 Bone Marrow 17 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 17 hour Negative

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
200         
 1633 50 2 1 0 0 0 0 1 4 0.08 0.06 10.00 8.00
    1637 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    1643 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1647 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    1653 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1655 50 0 1 0 0 0 0 1 2 0.04 0.02 2.00 0.00
    1662 50 1 2 0 0 0 0 4 7 0.14 0.10 8.00 4.00
    1664 50 1 3 0 0 0 0 0 4 0.08 0.02 8.00 2.00
Average         0.6 1.1 0.0 0.0 0.0 0.0 0.8 2.5 0.05 0.03 4.25 2.00
± SEM                         0.02 0.01 1.39 1.00
 
Test Chemical 2-Biphenylamine hydrochloride 
125         
 1638 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1640 50 2 3 0 0 0 0 1 6 0.12 0.06 6.00 4.00
    1641 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1642 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1645 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1654 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1657 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1666 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.3 0.4 0.0 0.0 0.0 0.0 0.1 0.8 0.02 0.01 0.75 0.50
± SEM                         0.02 0.01 0.75 0.50
 
Test Chemical 2-Biphenylamine hydrochloride 
250         
 1632 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1634 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    1635 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    1649 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1656 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1663 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    1670 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    1676 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
Average         0.5 0.3 0.0 0.0 0.0 0.0 0.0 0.8 0.02 0.01 1.50 1.00
± SEM                         0.01 0.00 0.50 0.38
 
Test Chemical 2-Biphenylamine hydrochloride 
500         
 1646 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1652 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1660 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    1672 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1674 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    1675 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.3 0.2 0.0 0.0 0.0 0.0 0.0 0.5 0.01 0.01 1.00 0.67
± SEM                         0.01 0.01 0.68 0.67
 
Vehicle Control No Stressor 
 0         
 1636 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1644 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    1648 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1658 50 1 1 0 0 0 0 1 3 0.06 0.04 4.00 2.00
    1665 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    1667 50 0 0 0 0 0 0 1 1 0.02 0.02 0.00 0.00
    1669 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    1673 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.3 0.3 0.0 0.0 0.0 0.0 0.3 0.8 0.02 0.01 1.00 0.50
± SEM                         0.01 0.01 0.53 0.33
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation