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Study Information
Study Attribute Value
CEBS Accession Number: 002-01294-0024-0000-4
Chemical Name: 2-Biphenylamine hydrochloride
CASRN: 2185-92-4
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 047126_CA
Study Result: Negative


Table Instructions and Notes:

Below are the detailed Chromosome Abberation data. You may also view the summary data for this study.


Initial Treatment Date Tissue Sample Time (h) Sex Species Strain Protocol Result
05/10/1988 Bone Marrow 36 Male Mouse B6C3F1 Intraperitoneal Injection x 1/study, 36 hour Negative

  Dose
(mg/kg)		 Animal
Number		 No.
Cells		 Chromatid Isochromatid Exchanges Aberrations
Breaks Gaps Breaks Gaps 'Tid 'Some Other Total Per Cell % Cells w/ Abs
(+ Gaps) (- Gaps) (+ Gaps) (- Gaps)
Positive Control Dimethylbenzanthracene 
50         
 8581 50 15 3 0 0 0 0 0 18 0.36 0.30 16.00 10.00
    8605 50 25 3 0 0 0 0 0 28 0.56 0.50 20.00 14.00
    8609 50 12 2 0 0 0 0 1 15 0.30 0.26 10.00 8.00
    8625 50 36 17 1 0 0 0 0 54 1.08 0.74 40.00 28.00
    8628 50 37 4 1 0 0 0 1 43 0.86 0.78 26.00 20.00
    8630 50 45 18 0 0 0 1 0 64 1.28 0.92 40.00 22.00
    8636 50 33 7 0 0 1 0 0 41 0.82 0.68 34.00 26.00
    8655 50 52 17 0 0 0 0 1 70 1.40 1.06 46.00 36.00
Average         31.9 8.9 0.3 0.0 0.1 0.1 0.4 41.6 0.83 0.66 29.00 20.50
± SEM                         0.14 0.10 4.58 3.38
 
Test Chemical 2-Biphenylamine hydrochloride 
62.5       
 8622 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    8634 50 0 3 0 0 0 0 0 3 0.06 0.00 6.00 0.00
    8637 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    8641 50 1 1 0 0 0 1 0 3 0.06 0.04 6.00 4.00
    8644 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    8646 50 0 2 0 0 0 0 1 3 0.06 0.02 2.00 0.00
    8652 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    8653 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.3 1.1 0.0 0.0 0.0 0.1 0.1 1.6 0.03 0.01 2.75 0.75
± SEM                         0.01 0.01 0.84 0.53
 
Test Chemical 2-Biphenylamine hydrochloride 
125         
 8638 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    8642 50 0 2 0 0 0 0 0 2 0.04 0.00 2.00 0.00
    8651 50 0 1 0 0 0 0 2 3 0.06 0.04 2.00 0.00
    8657 50 2 4 0 0 0 0 0 6 0.12 0.04 8.00 4.00
    8658 50 3 1 0 0 0 0 0 4 0.08 0.06 8.00 6.00
    8659 50 0 1 0 0 0 0 0 1 0.02 0.00 2.00 0.00
    8660 50 0 2 0 0 0 0 0 2 0.04 0.00 4.00 0.00
    8662 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
Average         0.9 1.5 0.0 0.0 0.0 0.0 0.3 2.6 0.05 0.02 4.00 1.75
± SEM                         0.01 0.01 0.93 0.80
 
Test Chemical 2-Biphenylamine hydrochloride 
250         
 8624 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    8627 50 2 1 0 0 0 0 0 3 0.06 0.04 6.00 4.00
    8632 50 1 0 0 0 0 0 0 1 0.02 0.02 2.00 2.00
    8643 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    8647 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    8648 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    8650 50 3 0 0 0 0 0 0 3 0.06 0.06 6.00 6.00
    8661 50 1 1 0 0 1 0 0 3 0.06 0.04 6.00 4.00
Average         1.3 0.5 0.0 0.0 0.1 0.0 0.0 1.9 0.04 0.03 3.75 2.75
± SEM                         0.01 0.01 0.80 0.65
 
Vehicle Control No Stressor 
 0         
 8588 50 1 3 0 0 0 0 0 4 0.08 0.02 4.00 2.00
    8593 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    8603 50 0 0 0 0 0 0 1 1 0.02 0.02 0.00 0.00
    8611 50 2 0 0 0 0 0 0 2 0.04 0.04 4.00 4.00
    8623 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
    8626 50 1 1 0 0 0 0 0 2 0.04 0.02 4.00 2.00
    8649 50 0 0 0 0 0 0 0 0 0.00 0.00 0.00 0.00
Average         0.6 0.6 0.0 0.0 0.0 0.0 0.1 1.3 0.03 0.01 1.71 1.14
± SEM                         0.01 0.01 0.81 0.59
 
Footnotes:
CRO: Corn Oil
DMBA: Dimethylbenzanthracene
IP/IJ: Intraperitoneal injection
INHAL: Inhalation