| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-01254-0016-0000-1 |
| Chemical Name: | 2,6-Toluenediamine dihydrochloride (2,6-diaminotoluene dihydrochloride) |
| CASRN: | 15481-70-6 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 051468_SCE |
| Study Result: | Negative |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 04/15/1986 | Bone Marrow | 23 | Male | Mouse | B6C3F1 | IP/IJ x 1, 23 hour | Negative |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Phosphate Buffered Saline |
0 |
3354 | 24 | 4.06 | ± | 0.385 |
| 3356 | 25 | 4.89 | ± | 0.479 | |||
| 3367 | 25 | 4.23 | ± | 0.446 | |||
| 3376 | 25 | 4.73 | ± | 0.434 | |||
| Average | 4.49 | ± | 0.199 | ||||
| Test Chemical | 2,6-Toluenediamine dihydrochloride (2,6-diaminotoluene dihydrochloride) |
45 |
3351 | 25 | 5.41 | ± | 0.470 |
| 3361 | 25 | 6.64 | ± | 0.675 | |||
| 3369 | 25 | 5.89 | ± | 0.479 | |||
| 3371 | 25 | 4.67 | ± | 0.523 | |||
| Average | 5.66 | ± | 0.414 | ||||
| Test Chemical | 2,6-Toluenediamine dihydrochloride (2,6-diaminotoluene dihydrochloride) |
90 |
3350 | 25 | 3.88 | ± | 0.558 |
| 3363 | 25 | 6.92 | ± | 0.744 | |||
| 3364 | 25 | 4.07 | ± | 0.537 | |||
| 3368 | 25 | 4.88 | ± | 0.539 | |||
| Average | 4.94 | ± | 0.697 | ||||
| Test Chemical | 2,6-Toluenediamine dihydrochloride (2,6-diaminotoluene dihydrochloride) |
180 |
3352 | 24 | 4.80 | ± | 0.379 |
| 3353 | 25 | 6.22 | ± | 0.514 | |||
| 3365 | 25 | 6.33 | ± | 0.647 | |||
| 3377 | 25 | 7.16 | ± | 0.710 | |||
| Average | 6.14 | ± | 0.489 | ||||
| Positive Control | Mitomycin-C |
0.5 |
3349 | 25 | 9.45 | ± | 0.572 |
| 3355 | 25 | 8.41 | ± | 0.640 | |||
| 3357 | 25 | 8.53 | ± | 0.537 | |||
| 3360 | 25 | 9.36 | ± | 0.543 | |||
| Average | 8.95 | ± | 0.271 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed