| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-01254-0016-0000-1 |
| Chemical Name: | 2,6-Toluenediamine dihydrochloride (2,6-diaminotoluene dihydrochloride) |
| CASRN: | 15481-70-6 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 051468_SCE |
| Study Result: | Negative |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 01/06/1987 | Bone Marrow | 23 | Male | Mouse | B6C3F1 | IP/IJ x 1, 23 hour | Negative |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Phosphate Buffered Saline |
0 |
4486 | 23 | 3.43 | ± | 0.413 |
| 4492 | 23 | 4.13 | ± | 0.462 | |||
| 4506 | 25 | 4.78 | ± | 0.421 | |||
| 4517 | 25 | 4.84 | ± | 0.426 | |||
| Average | 4.32 | ± | 0.331 | ||||
| Test Chemical | 2,6-Toluenediamine dihydrochloride (2,6-diaminotoluene dihydrochloride) |
135 |
4490 | 25 | 4.40 | ± | 0.360 |
| 4494 | 25 | 4.07 | ± | 0.296 | |||
| 4498 | 22 | 2.95 | ± | 0.262 | |||
| 4499 | 25 | 5.68 | ± | 0.595 | |||
| Average | 4.30 | ± | 0.562 | ||||
| Test Chemical | 2,6-Toluenediamine dihydrochloride (2,6-diaminotoluene dihydrochloride) |
180 |
4485 | 25 | 6.35 | ± | 0.673 |
| 4489 | 24 | 4.84 | ± | 0.538 | |||
| 4496 | 25 | 5.80 | ± | 0.472 | |||
| 4503 | 25 | 4.48 | ± | 0.448 | |||
| Average | 5.37 | ± | 0.431 | ||||
| Test Chemical | 2,6-Toluenediamine dihydrochloride (2,6-diaminotoluene dihydrochloride) |
225 |
4493 | 25 | 4.15 | ± | 0.379 |
| 4500 | 25 | 4.01 | ± | 0.402 | |||
| 4502 | 23 | 4.06 | ± | 0.383 | |||
| 4505 | 25 | 4.38 | ± | 0.323 | |||
| Average | 4.15 | ± | 0.082 | ||||
| Positive Control | Mitomycin-C |
0.5 |
4491 | 25 | 6.30 | ± | 0.497 |
| 4495 | 25 | 7.32 | ± | 0.596 | |||
| 4501 | 25 | 8.23 | ± | 0.829 | |||
| 4510 | 25 | 9.29 | ± | 0.620 | |||
| Average | 7.78 | ± | 0.638 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed