| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-01254-0016-0000-1 |
| Chemical Name: | 2,6-Toluenediamine dihydrochloride (2,6-diaminotoluene dihydrochloride) |
| CASRN: | 15481-70-6 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 051468_SCE |
| Study Result: | Negative |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 03/29/1988 | Bone Marrow | 42 | Male | Mouse | B6C3F1 | IP/IJ x 1, 42 hour | Negative |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Phosphate Buffered Saline |
0 |
8093 | 25 | 5.84 | ± | 0.499 |
| 8102 | 25 | 4.61 | ± | 0.463 | |||
| 8106 | 24 | 4.99 | ± | 0.493 | |||
| 8118 | 25 | 6.76 | ± | 0.660 | |||
| Average | 5.54 | ± | 0.478 | ||||
| Test Chemical | 2,6-Toluenediamine dihydrochloride (2,6-diaminotoluene dihydrochloride) |
2.5 |
8084 | 25 | 4.85 | ± | 0.494 |
| 8088 | 25 | 5.66 | ± | 0.427 | |||
| 8098 | 24 | 4.07 | ± | 0.368 | |||
| 8099 | 25 | 5.90 | ± | 0.502 | |||
| Average | 5.13 | ± | 0.415 | ||||
| Test Chemical | 2,6-Toluenediamine dihydrochloride (2,6-diaminotoluene dihydrochloride) |
5 |
8086 | 25 | 4.89 | ± | 0.566 |
| 8091 | 25 | 4.41 | ± | 0.372 | |||
| 8092 | 25 | 6.31 | ± | 0.623 | |||
| 8095 | 25 | 5.05 | ± | 0.465 | |||
| Average | 5.17 | ± | 0.406 | ||||
| Test Chemical | 2,6-Toluenediamine dihydrochloride (2,6-diaminotoluene dihydrochloride) |
10 |
8087 | 25 | 4.01 | ± | 0.278 |
| 8090 | 25 | 6.88 | ± | 0.573 | |||
| 8100 | 25 | 6.41 | ± | 0.414 | |||
| 8101 | 25 | 6.59 | ± | 0.722 | |||
| Average | 5.97 | ± | 0.662 | ||||
| Positive Control | Mitomycin-C |
0.5 |
8104 | 25 | 9.56 | ± | 0.689 |
| 8109 | 25 | 9.40 | ± | 0.552 | |||
| 8115 | 25 | 9.88 | ± | 0.469 | |||
| 8123 | 25 | 12.49 | ± | 0.840 | |||
| Average | 10.32 | ± | 0.726 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed