| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-01254-0016-0000-1 |
| Chemical Name: | 2,6-Toluenediamine dihydrochloride (2,6-diaminotoluene dihydrochloride) |
| CASRN: | 15481-70-6 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 051468_SCE |
| Study Result: | Negative |
Table Instructions and Notes:
Below are the detailed Sister Chromatid Exchange data. You may also view the summary data for this study.
| Initial Treatment Date | Tissue | Sample Time (h) | Sex | Species | Strain | Protocol | Trial Result |
|---|---|---|---|---|---|---|---|
| 06/01/1988 | Bone Marrow | 23 | Male | Mouse | B6C3F1 | IP/IJ x 1, 23 hour | Positive |
| Test Group | Dose (mg/kg) |
Animal Number |
No. Cells |
SCE / Cell | |||
|---|---|---|---|---|---|---|---|
| Mean | ± | SEM | |||||
| Vehicle Control | Phosphate Buffered Saline |
0 |
8700 | 25 | 5.46 | ± | 0.436 |
| 8712 | 25 | 6.18 | ± | 0.561 | |||
| 8714 | 25 | 5.96 | ± | 0.508 | |||
| 8722 | 25 | 5.35 | ± | 0.461 | |||
| Average | 5.74 | ± | 0.197 | ||||
| Test Chemical | 2,6-Toluenediamine dihydrochloride (2,6-diaminotoluene dihydrochloride) |
180 |
8716 | 25 | 5.80 | ± | 0.415 |
| 8718 | 25 | 7.71 | ± | 0.689 | |||
| 8719 | 25 | 7.06 | ± | 0.563 | |||
| 8720 | 25 | 7.47 | ± | 0.642 | |||
| Average | 7.02 | ± | 0.425 | ||||
| Test Chemical | 2,6-Toluenediamine dihydrochloride (2,6-diaminotoluene dihydrochloride) |
270 |
8715 | 25 | 7.76 | ± | 0.586 |
| 8717 | 25 | 6.14 | ± | 0.594 | |||
| Average | 6.94 | ± | 0.811 | ||||
| Positive Control | Mitomycin-C |
0.5 |
8702 | 25 | 6.98 | ± | 0.560 |
| 8706 | 25 | 12.43 | ± | 0.703 | |||
| 8721 | 25 | 13.51 | ± | 0.887 | |||
| 8728 | 25 | 9.14 | ± | 0.499 | |||
| Average | 10.54 | ± | 1.502 | ||||
Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed